Explore the vast range of titles available.

Background In dogs with congestive heart failure (CHF), the efficacy of torasemide, a loop diuretic, has been demonstrated. However, unlike in dogs and humans little has been described about the use of torasemide in the cat with spontaneous CHF. The objectives of this retrospective study were therefore to describe the therapeutic use of oral torasemide in cats with spontaneous CHF, document its potential adverse effects while reporting the clinical course of this feline population following torasemide administration in addition to standard medical therapy. Results Medical records of 21 client-owned cats with CHF (median age = 10.6 years [interquartile range (IQR) = 6.5–11.2]) receiving torasemide were reviewed. Data collected included torasemide dosages, other concurrent medications, physical examination features, echocardiographic data, and potential adverse effects during follow-up. A survival analysis was performed to estimate the time from diagnosis to cardiac death. Dyspnea related to CHF was identified in all cats (pleural effusion [8/21], pulmonary edema [5/21] or both [8/21]), associated with ascites in 4/21 cats. The CHF cause was determined by echocardiography in all cats: hypertrophic ( n  = 10), restrictive ( n  = 6), arrhythmogenic right ventricular ( n  = 3), dilated ( n  = 1) cardiomyopathies, and aortic valve abnormality ( n  = 1). At initiation, median torasemide dosage was 0.21 mg/kg [IQR = 0.17–0.23] q24h. Clinical signs declined in most cats (20/21) during the first 2 weeks with no remarkable adverse events. Median survival time after torasemide prescription was 182 days [IQR = 46–330]. A contemporary control group including 54 cats with CHF, receiving furosemide as sole loop diuretic treatment was compared with the study group. Median (IQR) survival time of cats in the control group was not significatively different ( p  = 0.962) from that of the torasemide group, i.e., 148 days (9–364), although the torasemide group included significantly more cats with recurrent episodes of CHF (52%) that the control group (19%). Conclusions This case series demonstrates that torasemide can be used in cats with spontaneous CHF. This therapeutic interest needs to be confirmed by prospective clinical trials.

First-hand accounts of the deadly assault describe it as well-planned and well-executed, reaffirming the potent threat of al Qaeda. Charlie Rose is the correspondent.

CHARLIE ROSE: Steve Martin is here. The legendary actor and comedian is also an avid writer. He’s written plays, children’s books, magazine pieces, a memoir, and a novella. Now he is publishing his first full-length novel. It is calledAn Object of Beauty. It is the story of an ambitious young art dealer fighting to reach the top of the New York City art world. In addition to his writing and film work, Martin also tours the country as a professional banjo player. His debut albumThe Crowwon a Grammy Award in 2008 and is still a bestselling album.

CHARLIE ROSE: While studying philosophy in college, Steve Martin got a job writing comedy for the Smothers Brothers and Sonny and Cher. But he longed to perform and soon took his standup act on the road. By 1977 he had become a fixture on such shows asThe Tonight ShowandSaturday Night Live. Martin was ready to make the transition to film.The Jerk, All of Me,Roxanne,andParenthoodare just some of his memorable films. But through it all he has been a writer not only for film and television, but short stories and now plays. His play,

CHARLIE ROSE: Steve Martin is here. He first made his mark as an Emmy Award—winning writer forThe Smothers Brothers Comedy Hourin the early 1970s. His long career spans the worlds of standup, television, film, theater, and books. He may be best known for such films asThe Jerk, All of Me, Roxanne,andL.A. Story. In the past few years, he has returned to where he began—writing. He has completed several plays, includingPicasso at the Lapin Agile. His new book,Pure Drivel, is a collection of his comic essays, taken mostly from theNew Yorker

July 15, 2005 - 60 Minutes's Charlie Rose reports on Marla Olmstead, a five-year-old girl with a remarkable ability to paint. Her abstract art has sold for thousands of dollars.

January 4, 2013 - The term 'design thinking' refers to incorporating human behavior into design. David Kelley and his Silicon Valley company IDEO have used this approach to create some of the world's most iconic products, including the computer mouse for Apple. Charlie Rose reports.

Former White House chief strategist Steve Bannon, during his brief tenure in the West Wing and his few months as CEO of President Trump's campaign, earned many nicknames among his admirers and his ever-expanding list of enemies. He was the great manipulator, Trump's Svengali, the Grim Reaper, Propagandist-in-chief. He describes himself as a street fighter and he proved it in this, his first-ever television interview.

In the coming days, America goes to the races. Weekend after next it's the Kentucky Derby, followed by the Preakness and the Belmont, the Triple Crown. And this coming weekend, there's a horse race you may not know about: the Maryland Hunt Cup.

The search to improve and eventually perfect artificial intelligence is driving the research labs of some of the most advanced and best-known American corporations. They are investing billions of dollars and many of their best scientific minds in pursuit of that goal.