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Haunted house murder
\"Haunted house murder: Newcomers to Tinker's Cove, Ty and Heather Moon have moved into a dilapidated house reputed to be a haven for ghosts. Now strange noises and flickering lights erupt from the house at all hours and neighborly relations are on edge. And when a local boy goes missing near the house, it's up to Lucy Stone to unravel the mystery of the eccentric couple and their increasingly frightful behavior\"-- Provided by publisher.
Book
Sharing consumers’ brand storytelling: influence of consumers’ storytelling on brand attitude via emotions and cognitions
Purpose
Brand storytelling has been found to be an effective marketing tool. Unlike a brand story that originates from a firm, consumers’ brand storytelling is created, developed and shared by consumers. This research aims to examine whether consumers’ brand storytelling leads to increased favorable brand evaluations and compares its effects on consumer cognition and emotions, to a brand story generated by a firm.
Design/methodology/approach
Three experiments were conducted to test the hypotheses. In Study 1, a 2 (story: consumers’ brand storytelling vs brand story by a firm) × 2 (product: coffee shop vs airline mileage programs) between-subjects design was used. Studies 2 and 3 replicated Study 1 and investigated different measurements of the constructs using different brands. Additionally, a mediation analysis was conducted.
Findings
The results show that consumers’ brand storytelling increases favorable brand attitudes. Consumers present deeper cognitive processing and higher experienced positive emotions when they read consumer brand storytelling as compared to a firm-created brand story, leading to a more favorable brand attitude.
Originality/value
There is a lack of empirical research investigating how consumers’ brand storytelling is different from brand stories created by firms, and how consumers’ brand storytelling influences brand attitudes. This study extends the literature by clarifying how consumers respond to consumers’ brand storytelling and evaluates brands by exploring the underlying mechanism for the effect of brand storytelling via consumers’ cognitions and emotions.
Journal Article
Improving financial literacy in college of business students: modernizing delivery tools
Purpose
The purpose of this paper is to develop and test through an experiment, an innovative online video teaching module that significantly improves financial literacy in college of business students. Specific business major financial literacy levels are also tested.
Design/methodology/approach
A total of 244 college of business students were given a financial literacy test. Half of the students were exposed to the “treatment” (watched a video module), while other half were not. The videos comprised 67 min of micro-lectures that students could download, free of charge, at their own convenience. The researchers analyzed the impact of a previous personal finance course on students’ financial literacy levels and tested across four business majors.
Findings
The video intervention was the most successful at increasing financial literacy, surprisingly more so than having taken a past personal finance course. Interaction effects were not significant. Four college majors were tested with a shorter, improved financial literacy measure – finding, to our surprise that non-quantitative business majors (particularly marketing students) are not less financially literate than other majors. Supporting past research, the authors found that female and African-American college students performed significantly lower on the test.
Originality/value
The research adds value to the literature by developing and testing a modern, novel teaching innovation to improve financial literacy in young adults. Using an experimental setting, the authors showed that the innovation was more effective than the commonly proscribed personal finance course. This is one of the few studies to measure financial literacy levels for specific college of business majors.
Journal Article
Polyamine pathway contributes to the pathogenesis of Parkinson disease
The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify brainstem regions differentially affected and resistant to the disease. Relying on these imaging findings, we then profiled gene expression levels from postmortem brainstem regions, identifying a disease-related decrease in the expression of the catabolic polyamine enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1). Next, a range of studies were completed to support the pathogenicity of this finding. First, to test for a causal link between polyamines and α-synuclein toxicity, we investigated a yeast model expressing α-synuclein. Polyamines were found to enhance the toxicity of α-synuclein, and an unbiased genome-wide screen for modifiers of α-synuclein toxicity identified Tpo4, a member of a family of proteins responsible for polyamine transport. Second, to test for a causal link between SAT1 activity and PD histopathology, we investigated a mouse model expressing α-synuclein. DENSPM (N1, N11-diethylnorspermine), a polyamine analog that increases SAT1 activity, was found to reduce PD histopathology, whereas Berenil (diminazene aceturate), a pharmacological agent that reduces SAT1 activity, worsened the histopathology. Third, to test for a genetic link, we sequenced the SAT1 gene and a rare but unique disease-associated variant was identified. Taken together, the findings from human patients, yeast, and a mouse model implicate the polyamine pathway in PD pathogenesis.
Journal Article
Reducing indwelling urinary catheter use through staged introduction of electronic clinical decision support in a multicenter hospital system
To integrate electronic clinical decision support tools into clinical practice and to evaluate the impact on indwelling urinary catheter (IUC) use and catheter-associated urinary tract infections (CAUTIs).Design, Setting, and ParticipantsThis 4-phase observational study included all inpatients at a multicampus, academic medical center between 2011 and 2015.InterventionsPhase 1 comprised best practices training and standardization of electronic documentation. Phase 2 comprised real-time electronic tracking of IUC duration. In phase 3, a triggered alert reminded clinicians of IUC duration. In phase 4, a new IUC order (1) introduced automated order expiration and (2) required consideration of alternatives and selection of an appropriate indication.
Overall, 2,121 CAUTIs, 179,070 new catheters, 643,055 catheter days, and 2,186 reinsertions occurred in 3·85 million hospitalized patient days during the study period. The CAUTI rate per 10,000 patient days decreased incrementally in each phase from 9·06 in phase 1 to 1·65 in phase 4 (relative risk [RR], 0·182; 95% confidence interval [CI], 0·153-0·216; P<·001). New catheters per 1,000 patient days declined from 53·4 in phase 1 to 39·5 in phase 4 (RR, 0·740; 95% CI, 0·730; P<·001), and catheter days per 1,000 patient days decreased from 194·5 in phase 1 to 140·7 in phase 4 (RR, 0·723; 95% CI, 0·719-0·728; P<·001). The reinsertion rate declined from 3·66% in phase 1 to 3·25% in phase 4 (RR, 0·894; 95% CI, 0·834-0·959; P=·0017).
The phased introduction of decision support tools was associated with progressive declines in new catheters, total catheter days, and CAUTIs. Clinical decision support tools offer a viable and scalable intervention to target hospital-wide IUC use and hold promise for other quality improvement initiatives.
Journal Article
Update and Overview of Outpatient Parenteral Antimicrobial Therapy Regulations and Reimbursement
Outpatient care, including outpatient parenteral antimicrobial therapy (OPAT), is increasingly seen by both clinicians and insurers as a safe, effective, and economical adjunct or alternative to hospitalization. Despite this, perhaps the least understood reimbursement and regulatory policies for health care services are those that apply to OPAT. We present a brief review and update of current rules and regulations relating to OPAT, with emphasis on areas of special interest to physicians serving as medical directors of home or ambulatory infusion programs or providing OPAT as an extension of their office practices.
Journal Article
Dysfunctional cognitions of depressive inpatients and their relationship with treatment outcome
Dysfunctional cognitions can contribute to depression and its maintenance. They may be related to a higher relapse rate and a longer duration of the depressive episode. The relevance of dysfunctional cognitions for acute inpatient treatment of unipolar depression is examined in this study and its variability by cognitive behavioural therapy (CBT).
222 patients suffering from Major Depressive Disorder (MDD) were evaluated during their inpatient treatment by assessing admission and discharge depression scores and their relationship to dysfunctional cognitions, using the Dysfunctional Attitude Scale (DAS). The relationship between dysfunctional cognitions and treatment outcome was examined. Primary outcome measures were the Hamilton-Rating-Scale (HRSD) and the Beck Depression Inventory (BDI).
Higher age, depression severity at admission, comorbid personality disorders and recurrent depressive disorders are related with higher DAS-scores at admission. DAS-Scores declined during treatment but to a lower extend than depressive symptom scales (effect size dDAS-G t1-t2 = .31; dHRSD t1-t2 = 2.88; dBDI t1-t2 = 1.38). Higher DAS-scores at admission correlated negatively with the improvement of depressive symptoms during treatment (HRSD: r = −.62; p < .01; BDI: r = −.54; p < .01) and remission rates (HRSD: r = −.65; p < .01; BDI: r = −.48; p < .01). CBT did not additionally reduce DAS-scores compared to pharmacotherapy only.
Dysfunctional cognitions are relatively stable compared to other depressive symptoms and are associated with poorer treatment outcome even in combined treatment of antidepressant medication and CBT during inpatient treatment. Changes of dysfunctional cognitions seem to be a long-term treatment goal, especially because of their association with comorbid personality disorders and recurrent depressive disorders.
Journal Article
Application of Artificial Neural Networks in Predicting the Thermal Performance of Heat Pipes
The loss of energy by heat is a common problem in almost all areas of industry, and heat pipes are essential to increase efficiency and reduce energy waste. However, in many cases, they have complex theoretical equations with high percentages of error, limiting their development and causing dependence on empirical methods that generate a waste of time and material, resulting in significant expenses and reducing the viability of their use. Thus, Artificial Neural Networks (ANNs) can be an excellent option to facilitate the construction and development of heat pipes without knowledge of the complex theory behind the problem. This investigation uses experimental data from previous studies to evaluate the ability of three different ANNs to predict the thermal performance of heat pipes with different capillary structures, each of them in various configurations of the slope, filling ratio, and heat load. The goal is to investigate results in as many different scenarios as possible to clearly understand the networks’ capacity for modeling heat pipes and their operating parameters. We chose two classic ANNs (the most used, Multilayer Perceptron (MLP) network, and the Radial Basis Function (RBF) network) and the Extreme Learning Machine (ELM), which has not yet been applied to heat pipes studies. The ELM is an Unorganized Machine with a fast training process and a simple codification. The ANN results were very close to the experimental ones, showing that ANNs can successfully simulate the thermal performance of heat pipes. Based on the RMSE (error metric being reduced during the training step), the ELM presented the best results (RMSE = 0.384), followed by MLP (RMSE = 0.409), proving their capacity to generalize the problem. These results show the importance of applying different ANNs to evaluate the system deeply. Using ANNs in developing heat pipes is an excellent option for accelerating and improving the project phase, reducing material loss, time, and other resources.
Journal Article
Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study
The cognitive profile of early onset Parkinson’s disease (EOPD) has not been clearly defined. Mutations in the parkin gene are the most common genetic risk factor for EOPD and may offer information about the neuropsychological pattern of performance in both symptomatic and asymptomatic mutation carriers. EOPD probands and their first-degree relatives who did not have Parkinson’s disease (PD) were genotyped for mutations in the parkin gene and administered a comprehensive neuropsychological battery. Performance was compared between EOPD probands with (N = 43) and without (N = 52) parkin mutations. The same neuropsychological battery was administered to 217 first-degree relatives to assess neuropsychological function in individuals who carry parkin mutations but do not have PD. No significant differences in neuropsychological test performance were found between parkin carrier and noncarrier probands. Performance also did not differ between EOPD noncarriers and carrier subgroups (i.e., heterozygotes, compound heterozygotes/homozygotes). Similarly, no differences were found among unaffected family members across genotypes. Mean neuropsychological test performance was within normal range in all probands and relatives. Carriers of parkin mutations, whether or not they have PD, do not perform differently on neuropsychological measures as compared to noncarriers. The cognitive functioning of parkin carriers over time warrants further study. (JINS, 2011, 17, 1–10)
Journal Article
AN EMPIRICAL INVESTIGATION INTO THE RELATIONSHIP BETWEEN COMPUTER SELF-EFFICACY, ANXIETY, EXPERIENCE, SUPPORT AND USAGE
In developing an integrative framework for research on computer self-efficacy, researchers found that [Bandura] and others had identified over twenty-three antecedent and consequent factors that are theoretically related to computer selfefficacy (40). Figure 1 is a model of a subset of the factors related to self-efficacy.
Journal Article