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"Rossi, Francesca"
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Aladdin : a story from Arabian nights
\"A sudden flash of blue light forced Aladdin to cover his face with his hands. When the young man finally lowered his hands, he was shocked by what appeared before him. It was a huge genie, hovering in midair!\"--Page 4 of cover.
Book
Method and Practice for Integrated Water Landscapes Management: River Contracts for Resilient Territories and Communities Facing Climate Change
The negative impacts of climate change on natural and anthropic ecosystems have led to the increasingly urgent search for policies, strategies and tools able to counteract degradation and risk factors on vulnerable landscapes. Among these, the research activity refers to water landscapes as a specific field of study that represents a fundamental resource for human well-being. In consistency with the international policy framework on integrated water management, this contribution develops a case study analysis focused on River Contracts as innovative, voluntary and negotiated planning practices aimed at the reconstruction of territorial, social and ecological values, which broaden the boundaries of safeguarding by integrating protection actions with sustainable management and environmental regeneration and to restore the identity of places and local communities. The description and evaluation of an ongoing experience of River, Coast and Landscape Contracts, developed along the coast of the Lazio region, allows one to point out that the process method is successful in solving complex issues related to the management of the river basin while involving social actors in order to improve people’s knowledge of the territory, increase social awareness of risk conditions, and allow local communities to propose and implement shared solutions. The results of this territorial and multi-level governance method are therefore measured on their capacity to produce territorial, social and environmental resilience.
Journal Article
Snow White : from a fairy tale by the Brothers Grimm
A beautifully illustrated retelling of the classic tale of Snow White.
Book
Emerging Roles of the Iron Chelators in Inflammation
Iron is a crucial element for mammalian cells, considering its intervention in several physiologic processes. Its homeostasis is finely regulated, and its alteration could be responsible for the onset of several disorders. Iron is closely related to inflammation; indeed, during inflammation high levels of interleukin-6 cause an increased production of hepcidin which induces a degradation of ferroportin. Ferroportin degradation leads to decreased iron efflux that culminates in elevated intracellular iron concentration and consequently iron toxicity in cells and tissues. Therefore, iron chelation could be considered a novel and useful therapeutic strategy in order to counteract the inflammation in several autoimmune and inflammatory diseases. Several iron chelators are already known to have anti-inflammatory effects, among them deferiprone, deferoxamine, deferasirox, and Dp44mT are noteworthy. Recently, eltrombopag has been reported to have an important role in reducing inflammation, acting both directly by chelating iron, and indirectly by modulating iron efflux. This review offers an overview of the possible novel biological effects of the iron chelators in inflammation, suggesting them as novel anti-inflammatory molecules.
Journal Article
Rapunzel : from a fairy tale by the Brothers Grimm /
A beautifully illustrated retelling of the classic tale of Rapunzel.
Book
New trends in intellectual capital reporting
PurposeThe purpose of this paper is to explore a new way to disclose intellectual capital (IC) in universities through their websites. Going beyond traditional tools used for intellectual capital disclosure (ICD), this study aims at identifying possible determinants of ICD via the web.Design/methodology/approachThis paper analyses the institutional websites of a sample of Italian universities adapting the theoretical framework developed by Low et al. (2015) to the peculiarities of the Italian university system. Moreover, the relationship between certain explanatory factors identified in previous research and the extent of online ICD represented by two disclosure indexes was tested through an ordinary least squares regression model.FindingsThe analysis reveals the extensive use of ICD via websites, especially regarding human and internal capital, while the disclosure of external capital through this means is still limited. Internationality and online visibility both positively affect the extent of a university’s ICD.Research limitations/implicationsThe paper represents the first study investigating online ICD and its determinants in universities, contributing new knowledge to help answer the how and what of the matter.Practical implicationsThe results can serve as encouragement to university managers to enhance online ICD to meet the information needs of a wider audience.Originality/valueThis is the first study to provide evidence about online ICD in universities and to reveal some of the possible determinants to improve this disclosure.
Journal Article
The little mermaid : based on a fairy tale by Hans Christian Andersen
A little sea princess, longing to be human, trades her mermaid's tail for legs to win the love of a prince.
Book
Handbook of constraint programming
Constraint programming is a powerful paradigm for solving combinatorial search problems that draws on a wide range of techniques from artificial intelligence, computer science, databases, programming languages, and operations research. Constraint programming is currently applied with success to many domains, such as scheduling, planning, vehicle routing, configuration, networks, and bioinformatics.The aim of this handbook is to capture the full breadth and depth of the constraint programming field and to be encyclopedic in its scope and coverage. While there are several excellent books on constraint programming, such books necessarily focus on the main notions and techniques and cannot cover also extensions, applications, and languages. The handbook gives a reasonably complete coverage of all these lines of work, based on constraint programming, so that a reader can have a rather precise idea of the whole field and its potential. Of course each line of work is dealt with in a survey-like style, where some details may be neglected in favor of coverage. However, the extensive bibliography of each chapter will help the interested readers to find suitable sources for the missing details. Each chapter of the handbook is intended to be a self-contained survey of a topic, and is written by one or more authors who are leading researchers in the area.The intended audience of the handbook is researchers, graduate students, higher-year undergraduates and practitioners who wish to learn about the state-of-the-art in constraint programming. No prior knowledge about the field is necessary to be able to read the chapters and gather useful knowledge. Researchers from other fields should find in this handbook an effective way to learn about constraint programming and to possibly use some of the constraint programming concepts and techniques in their work, thus providing a means for a fruitful cross-fertilization among different research areas.The handbook is organized in two parts. The first part covers the basic foundations of constraint programming, including the history, the notion of constraint propagation, basic search methods, global constraints, tractability and computational complexity, and important issues in modeling a problem as a constraint problem. The second part covers constraint languages and solver, several useful extensions to the basic framework (such as interval constraints, structured domains, and distributed CSPs), and successful application areas for constraint programming.- Covers the whole field of constraint programming- Survey-style chapters- Five chapters on applications
eBook
Beauty and the beast
Retelling of the classic fairy tale about a girl whose great capacity to love releases a prince from the spell which has made him an ugly beast.
B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus
ObjectiveWhile the contribution of B-cells to SLE is well established, its role in chronic cutaneous lupus erythematosus (CCLE) remains unclear. Here, we compare B-cell and serum auto-antibody profiles between patients with systemic lupus erythematosus (SLE), CCLE, and overlap conditions.MethodsB-cells were compared by flow cytometry amongst healthy controls, CCLE without systemic lupus (CCLE+/SLE−) and SLE patients with (SLE+/CCLE+) or without CCLE (SLE+/CCLE−). Serum was analyed for autoreactive 9G4+, anti-double-stranded DNA, anti-chromatin and anti-RNA antibodies by ELISA and for anti-RNA binding proteins (RBP) by luciferase immunoprecipitation.ResultsPatients with CCLE+/SLE− share B-cell abnormalities with SLE including decreased unswitched memory and increased effector B-cells albeit at a lower level than SLE patients. Similarly, both SLE and CCLE+/SLE- patients have elevated 9G4+ IgG autoantibodies despite lower levels of anti-nucleic acid and anti-RBP antibodies in CCLE+/SLE−. CCLE+/SLE− patients could be stratified into those with SLE-like B-cell profiles and a separate group with normal B-cell profiles. The former group was more serologically active and more likely to have disseminated skin lesions.ConclusionCCLE displays perturbations in B-cell homeostasis and partial B-cell tolerance breakdown. Our study demonstrates that this entity is immunologically heterogeneous and includes a disease segment whose B-cell compartment resembles SLE and is clinically associated with enhanced serological activity and more extensive skin disease. This picture suggests that SLE-like B-cell changes in primary CCLE may help identify patients at risk for subsequent development of SLE. B-cell profiling in CCLE might also indentify candidates who would benefit from B-cell targeted therapies.
Journal Article