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Background With improving survival rates, cancer has become more of a chronic disease with long-term palliative care requirements. Thus, it is even more than ever necessary to pay careful attention to the well-being of family caregivers of cancer patients, as cancer trajectory is a challenging path for both patients and their caregivers. This study focusses on ascertaining the level of quality of life (QoL) domains and their attributable significant factors among a population of cancer family caregivers. Methods This was a cross-sectional study. The study population consist of caregivers of adult cancer patients in Zanjan, Iran between 2019 and 2020. Medical Outcomes General Health Survey Short Form 36 (SF-36) was the instrument to measure outcome variables. Clinical and basic characteristics of the caregivers and their patients were also collected using a questionnaire designed for this purpose. Data were analyzed using Independent samples t-test, Analysis of Variance, and stepwise linear regression in SPSS v.26. Results Of the caregivers 167 were male and 133 were female. The mean age of the participants was 40.77 ± 12.56, most of whom were offspring of the patients (148, 49.3%), married (239, 79.7%), and self-employed (81, 27.0%). both domains of bodily pain (76.50 ± 16.67) and physical functioning (74.88 ± 20.27) showed the highest scores among caregivers. Age and gender of caregivers, duration of caregiving, Eastern Cooperative Oncology Group (ECOG) performance status scale as well as type and stage of cancer, and type of treatment were among the significant predictors of QoL domains (All, p < 0.001). Conclusion Findings of the present study substantiated various significant predictors for QoL along with low levels of QoL domains among the caregivers of cancer patients. Securing such findings proves the magnitude of probable unmet needs and psychological challenges in this population and provides the health policy makers with some valuable clues to draw effective strategies to address such issues.

With the extensively spread of industrialization in the world, noise exposure is becoming more prevalent in the industrial settings. The most important and definite harmful effects of sound include hearing loss, both permanent and temporary. This study was designed aimed to use the C5 algorithm to determine the weight of factors affecting the workers' hearing loss based on the audiometric data. This cross-sectional, descriptive, analytical study was conducted in 2018 in a mining industry in southeastern Iran. In this study, workers were divided into three exposed groups with different sound pressure levels (one control group and two case groups). Audiometry was conducted for each group of 50 persons; hence, the total number of subjects was 150. The stages of this study include: 1) selecting factors (predictive) to check and weigh them; 2) conducting the audiometry for both ears; 3) calculating the permanent hearing loss in each ear and permanent hearing loss of both ears; 4) classifying the types of hearing loss; and 5) investigating and determining the weight of factors affecting the hearing loss and their classification based on the C5 algorithm and determining the error and accuracy rate of each model. To assess and determine the factors affecting the hearing loss of workers, the C5 algorithm and IBM SPSS Modeler 18.0 were used. SPSS V.18 was used to analyze the linear regression and paired t-test tests, too. The results showed that in the first model (SPL <70 dBA), the 8KHz frequency with the weight of 31% had the highest effect, the factors of work experience and the frequency of 250Hz each with the weight of 3%, had the least effect, and the accuracy of the model was 100%. In the second model (SPL 70-80 dBA) the frequency of 8KHz with the weight of 21% had the highest effect, the frequency of 250Hz and the working experience each had the lowest effect with the weight of 7% and the accuracy of the model was calculated as 100%. In the third model (SPL >85 dBA), the 4KHz frequency with the weight of 31% had the highest effect, and the work experience with a weight of 1% had the lowest effect, and the accuracy of the model was 94%. In the fourth model, the 4KHz frequency with the weight of 22% had the highest effect and 250Hz and age each with the weight of 8% had the lowest effects; the accuracy of this model was calculated to be 99.05%. During investigating and determining the weight of the factors affecting hearing loss by the C5 algorithm, the high weight and effect of the 4KHz frequency were predicted in hearing loss changes. Considering the high accuracy obtained in this modeling, this algorithm is a suitable and powerful tool for predicting and modeling the hearing loss.

Background Chemoradiotherapy complications has always been of great concern to both clinicians and patients during the course of treatment. The purpose of the present study was to examine the effectiveness of oral famotidine on the reduction of hematologic complications of patients with esophageal and gastric cardia cancers undergoing radiotherapy. Methods A single-blind controlled trial was conducted on 60 patients with esophageal and cardia cancers, who were undergoing chemoradiotherapy. Patients were randomly assigned to 2 groups with 30 patients to receive either 40 mg of oral famotidine (daily and 4 h before each session) or placebo. Complete blood count with differential, platelet counts, and hemoglobin levels were obtained weekly during treatment. The main outcome variables were lymphocytopenia, granulocytopenia, thrombocytopenia, and anemia. Results The findings indicated a significant effect of famotidine on reduction of thrombocytopenia among intervention group compared to control group ( P  < 0.0001). Even so, the effect of intervention was not significant for other outcome variables (All, P  ≥ 0.05). The lymphocyte ( P  = 0.007) and platelet ( P  = 0.004) counts were also significantly greater in famotidine group in comparison with placebo group at the end of the study. Conclusion As evidenced by the findings of the current study, famotidine might be recommended as an effective radioprotective agent among patients with esophageal and gastric cardia cancers to prevent Leukocyte and platelet reduction to some extent. Trial registration This study was prospectively registered at irct.ir (Iranian Registry of Clinical Trials) with the code IRCT20170728035349N1, 2020-08-19.

Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that may result in adverse pregnancy outcomes, posing a significant risk to both the mother and the fetus. The major purpose of the current study was to investigate the impact of SLE on the outcomes of pregnancy among women with SLE. This was a retrospective cohort study. Two groups of pregnant women, one with Systemic Lupus Erythematosus (SLE) and one without SLE, were included at the Gynecology and Obstetrics Clinic of Ayatollah Mousavi Hospital in Zanjan, Iran, from 2019 to 2020. Participants from both cohorts completed a checklist of study variables based on their medical records. The data were analyzed using binary logistic regression, chi-square test, analysis of variance, and independent samples t-test with SPSS software version 23. The research involved 400 pregnant women, with the mean age of the SLE and non-SLE groups being 36.68±4.90 and 29.46±6.56 years, respectively. The most prevalent adverse outcome was cesarean section (271 [67.8%]), significantly higher in the SLE group (54.5% vs. 10.0%, P=0.0001). The likelihood of experiencing spontaneous abortion, preterm labor, cesarean section, and LBW was increased by more than 6.5 times (odds ratio, 6.54; 95% CI, 2.22-19.27; P=0.001), 3.6 times (odds ratio, 3.67; 95% CI, 1.47-9.18; P=0.005), 18.9 times (odds ratio, 18.94; 95% CI, 6.46-55.49; P=0.0001), and 3 times (odds ratio, 3.04; 95% CI, 1.09-8.46; P=0.030) in individuals with SLE, respectively. Women with SLE have an increased likelihood of encountering spontaneous abortion, preterm labor, cesarean section, and delivering a low-birth-weight infant.

Background Deciding whether a cranial Computed Tomography (CT) scan in a patient with minor head trauma (MHT) is necessary or not has always been challenging. Diagnosing Traumatic Brain Injury (TBI) is a fundamental part of MHT managing especially in children who are more vulnerable in terms of brain CT radiation consequences and TBI. Defining some indications to timely and efficiently predict the likelihood of TBI is necessary. Thus , we aimed to determine the impact of clinical findings to predict the need for brain CT in children with MHT. Methods In a prospective cohort study, 200 children (2 to 14 years) with MHT were included from 2019 to 2020. The data of MHT-related clinical findings were gathered. The primary and secondary outcomes were defined as a positive brain CT and any TBI requiring neurosurgery intervention, respectively. In statistical analysis, we performed Binary Logistic regression analysis, Fisher’s exact test and independent samples t-test using SPSS V.26. Results The mean age of participants was 6.5 ± 3.06 years. Ninety patients underwent brain CT. The most common clinical finding and injury mechanism were headache and falling from height, respectively. The results of brain CTs were positive in seven patients (3.5%). We identified three predicting factors for an abnormal brain CT including headache, decreased level of consciousness, and vomiting. Conclusion We showed that repetitive vomiting (≥2), headache, and decreased level of consciousness are predicting factors for an abnormal brain CT in children with MHT.

Background Neck pain and disability is a significant public health problem with only very few evidence-based treatment option. The aim of this study was to evaluate the effect of isometric exercise on pain and disability of cervical spondylosis. Methods Twenty four patients with cervical osteoarthritis and neck pain (22 females and 2 males; mean age, 46.70 ± 13.71 years) were recruited and randomly allocated into 2 arms: neck isometric exercises (n = 12) and conservative management without exercise (n = 12). The Neck Disability Index (NDI) and Neck Pain and Disability Scale (NPAD) were used to assess participants at baseline and after 4 weeks. Results Basic characteristics, NDI score and NPAD score were not significantly different between groups at baseline. The exercise arm demonstrated significantly lower scores regarding NDI (mean, 17.41 vs. 25.58; P-value = 0.035) and NPAD (mean, 25.33 vs. 66.67; P < 0.001), compared to the control arm after 4 weeks. The exercise arm also showed significant within group reduction considering NDI and NPAD scores after 4 weeks (Both, P < 0.001). Conclusion Our findings suggested that isometric exercises might be a beneficial treatment for improving pain and disability caused by cervical spondylosis. Trial registration This study was registered at irct.ir (Iranian Registry of Clinical Trials) with the code IRCT20220206053950N1, 07.05.2022, retrospectively registered.

The aim of the study study was to model, with the use of a neural network algorithm, the significance of a variety of factors influencing the development of hearing loss among industry workers. The workers were categorized into three groups, according to the A-weighted equivalent sound pressure level of noise exposure: Group 1 (LAeq < 70 dB), Group 2 (LAeq 70–80 dB), and Group 3 (LAeq > 85 dB). The results obtained for Group 1 indicate that the hearing thresholds at the frequencies of 8 kHz and 1 kHz had the maximum effect on the development of hearing loss. In Group 2, the factors with maximum weight were the hearing threshold at 4 kHz and the worker’s age. In Group 3, maximum weight was found for the factors of hearing threshold at a frequency of 4 kHz and duration of work experience. The article also reports the results of hearing loss modeling on combined data from the three groups. The study shows that neural data mining classification algorithms can be an effective tool for the identification of hearing hazards and greatly help in designing and conducting hearing conservation programs in the industry.

Behçet's Disease (BD) is a systemic vasculitis, highly prevalent in Eastern Asia to Mediterranean countries. Iran is among the countries with the highest prevalence of BD, and previous studies in different countries have shown a broad range of clinical manifestations of the disease. The present study is conducted to evaluate the prevalence of the clinical manifestations of BD in patients referring to rheumatology clinics of two distinct referral hospitals in Tehran and Zanjan, Iran. In this retrospective, cross-sectional study, the medical records of patients with BD were reviewed, and age at onset, sex, the delay between the onset of symptoms and diagnosis, clinical manifestations, HLA B27, HLA B51, HLA B5, haematuria, proteinuria, leukocyturia, Erythrocyte Sedimentation Rate (ESR), and pathergy phenomenon were included in the study. The collected data were analysed by χ test using SPSS 23. A total of 188 patients (Male/female ratio = 1.47) were included in the study with mean ± SD age at onset of 27.98 ± 10.47 years and a mean ± SD of delay between the onset of symptom and diagnosis of 5.70 ± 7.16 years. The most common clinical manifestation was mucosal involvement (85.1%), followed by the ocular lesion (55.3%) and skin manifestations (44.7%). The Pathergy phenomenon was observed in 98 patients (52.1%). Moreover, 45.2% had positive HLA B5, followed by HLA B51 (35.1%) and HLA B27 (12.2%). This study demonstrated that male/female ratio and mean age at onset were comparable to the results of previous studies in Iran. Significant associations between HLAB5 and clinical manifestations underline the pivotal role of genetic factors in BD.

Aims: Nitrates in drinking water which may come from nitrogen fertilizers applied to crops are a potential health risk. The present study was conducted to investigate the application of alternating current (AC) in electrocoagulation (EC) process for nitrate removal from aqueous solution and linear and nonlinear isotherm modeling.Materials and Methods: The experiments were performed in pilot scale. The effective parameters including solution pH, the initial concentration of nitrate, total dissolved solids, contact time, and current density were studied. Results: The obtained results showed that with increasing solution pH from 3 to 10, the sinusoidal removal efficiency was observed. With increasing current density from 0.5 to 2 A/cm2, the nitrate removal efficiency was ascended from 32% to 58%. The optimum electrolyte was 2 g/L of NaCl. With increasing contact time and decreasing initial nitrate concentration, the nitrate removal efficiency was enhanced. In addition, the adsorption NO3by AC EC was preferably fitted with Langmuir isotherm. Conclusion: The results showed that the EC process could remove the nitrate to less than Iranian standard limit. The solution pH, current density, and contact time were showed the direct effect and initial concentration of nitrate depicted the reverse effect on nitrate removal efficiency.

Members of the genus Argulus, or fish lice, are common parasites of fresh water fish. The present study aimed to investigate necessarily the rate of infestation by argulids and determine the infesting species in goldfish in order to control the invasion of parasite in native and cultured fish population. For the present study, 1200 live goldfish were collected randomly from 10 ornamental fish farms from different areas of Iran in summer 2010 and were investigated macroscopically and microscopically. The number of parasites in every infested fish was numerated and identified by the morphologic key characteristics under light microscope as alive and as fixed in 70% ethyl alcohol. The results showed that 19.17% of sampled goldfish were infested with Argulus coregoni (Thorell, 1864), Argulus japonicus (Thiele, 1900), and Argulus foliaceus (Linnaeus, 1758). The most frequent infestation was with A. japonicus (12.5 %), the least frequent was with A. coregoni (1.6%), and the frequency of A. foliaceus infestation was 5%. Moreover, in this study, multi-cellular and unicellular parasites such as Gyrodactylus spp, Dactylogyrus spp, Trichodina spp and Ichthyophthirius multifiliis (Fouquet, 1876), were observed in infested fish.