Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
203
result(s) for
"Roth, Emily"
Sort by:
Comparison of Three Clinical Trial Treatments for Autism Spectrum Disorder Through Multivariate Analysis of Changes in Metabolic Profiles and Adaptive Behavior
Several studies associate autism spectrum disorder (ASD) pathophysiology with metabolic abnormalities related to DNA methylation and intracellular redox homeostasis. In this regard, three completed clinical trials are reexamined in this work: treatment with (i) methylcobalamin (MeCbl) in combination with low-dose folinic acid (LDFA), (ii) tetrahydrobiopterin, and (iii) high-dose folinic acid (HDFA) for counteracting abnormalities in the folate-dependent one-carbon metabolism (FOCM) and transsulfuration (TS) pathways and also for improving ASD-related symptoms and behaviors. Although effects of treatment on individual metabolites and behavioral measures have previously been investigated, this study is the first to consider the effect of interventions on a set of metabolites of the FOCM/TS pathways and to correlate FOCM/TS metabolic changes with behavioral improvements across several studies. To do so, this work uses data from one case-control study and the three clinical trials to develop multivariate models for considering these aspects of treatment. Fisher discriminant analysis (FDA) is first used to establish a model for distinguishing individuals with ASD from typically developing (TD) controls, which is subsequently evaluated on the three treatment data sets, along with one data set for a placebo, to characterize the shift of FOCM/TS metabolism toward that of the TD population. Treatment with MeCbl plus LDFA and, separately, treatment with tetrahydrobiopterin significantly shifted the metabolites toward the values of the control group. Contrary to this, treatment with HDFA had a lesser, though still noticeable, effect whilst the placebo group showed marginal, but not insignificant, variations in metabolites. A second analysis is then performed with non-linear kernel partial least squares (KPLS) regression to predict changes in adaptive behavior, quantified by the Vineland Adaptive Behavior Composite, from changes in FOCM/TS biochemical measurements provided by treatment. Incorporating the 74 samples receiving any treatment, including placebo, into the regression analysis yields an
of 0.471 after cross-validation when using changes in six metabolic measurements as predictors. These results are suggestive of an ability to effectively improve pathway-wide FOCM/TS metabolic and behavioral abnormalities in ASD with clinical treatment.
Journal Article
Vitamin D, Folate, Vitamin B 12 , and Iron Status in Pregnant/Postpartum Old Order Anabaptist Women in Southwestern Ontario
Purpose: To assess vitamin D, folate, vitamin B 12 , and iron status in Old Order Anabaptist (OOA) pregnant/postpartum women. Methods: Blood was analyzed for plasma 25 hydroxy vitamin D (25(OH)D), red blood cell (RBC) folate, serum vitamin B 12 , and iron status indicators. Dietary intakes (food and supplements) from 3-day estimated records were compared to Dietary Reference Intakes and Canada’s Food Guide (2007). Results: Fifty women participated in this descriptive cross-sectional study. Concentrations of 25(OH)D were low (<50 nmol/L for 20% and < 75 nmol/L for 63%); 42% had total vitamin D intakes < estimated average requirement (EAR). All women had RBC folate above the 1360 mmol/L cut-off. Nineteen percent had folate intakes upper limit. One woman had low serum vitamin B 12 (<148 pmol/L); serum vitamin B 12 was high (>652 pmol/L) for 24%. None had vitamin B 12 intakes
Journal Article
K-8, Private, Midwestern School Principals and Their Experiences of Work Demand
The problem that was addressed through this study is increasing job demands and insufficient job resources plaguing K-8 principals across the nation. The purpose of this basic qualitative study was to investigate K-8 principals’ perceptions of increased work demands and their influence on excessive stress, burnout, and turnover in a private, Midwestern school district. Bakker and Demerouti’s job demands-resources theory served as the theoretical foundation for this study. Data were collected from semistructured interviews with 10 principals from the same district. Participant responses were analyzed through several rounds of coding, which led to the emergence of the following six themes: (1) most participants have a negative work-life balance due to overwhelming job demands; (2) resource constraints prohibit principals from effectively doing their jobs; (3) principals desire a leadership team with whom to collaborate and make decisions; (4) principals face role conflict as they are required to cover additional duties outside of their role; (5) participants experience serious health conditions due to escalating job demands; and (6) some principals embrace a mindset shift to help them maintain balance and sustainability in their role. The implications for positive social change are the recommendations for principals on improving the sustainability of the principal role with a focus on a healthy work-life balance and overall wellness. As the principal’s longevity in a school can be tied to student achievement, staffing turnover, and school climate and culture, all school stakeholders can benefit from this research.
Dissertation
Imputation for Lipidomics and Metabolomics
Motivation: Missing values are prevalent in high-throughput measurements due to various experimental or analytical reasons. Imputation, the process of replacing missing values in a dataset with estimated values, plays an important role in multivariate and machine learning analyses. The three missingness patterns, including missing completely at random, missing at random, and missing not at random, describe unique dependencies between the missing and observed data. The optimal imputation method for each dataset depends on the type of data, the cause of the missingness, and the nature of relationships between the missing and observed data. The challenge is to identify the optimal imputation solution for a given dataset. Availability and implementation: ImpLiMet is freely available at https://complimet.ca/shiny/implimet/ and https://github.com/complimet/ImpLiMet.
Journal Article
Vitamin D, Folate, Vitamin B.sub.12, and Iron Status in Pregnant/Postpartum Old Order Anabaptist Women in Southwestern Ontario
Purpose: To assess vitamin D, folate, vitamin [B.sub.12], and iron status in Old Order Anabaptist (OOA) pregnant/postpartum women. Methods: Blood was analyzed for plasma 25 hydroxy vitamin D (25(OH)D), red blood cell (RBC) folate, serum vitamin [B.sub.12], and iron status indicators. Dietary intakes (food and supplements) from 3-day estimated records were compared to Dietary Reference Intakes and Canada's Food Guide (2007). Results: Fifty women participated in this descriptive cross-sectional study. Concentrations of 25(OH)D were low (<50 nmol/L for 20% and <75 nmol/L for 63%); 42% had total vitamin D intakes < estimated average requirement (EAR). All women had RBC folate above the 1360 mmol/L cut-off. Nineteen percent had folate intakes upper limit. One woman had low serum vitamin [B.sub.12] (<148 pmol/L); serum vitamin [B.sub.12] was high (>652 pmol/L) for 24%. None had vitamin [B.sub.12] intakes 652 pmol/l) pour 24 % des femmes. Aucune n'avait un apport en vitamine [B.sub.12] inferieur au BME; les apports etaient eleves comparativement a l'apport alimentaire recommande. Une femme presentait un taux d'hemoglobine faible; 13 % avaient un taux de ferritine inferieur a 15 [micro]g/l. Treize pour cent avaient un apport total en fer inferieur au BME. Conclusions. Dans l'ensemble, l'apport alimentaire et l'etat nutritionnel en micronutriments seriques des femmes AAO enceintes et en post-partum de notre etude etaient similaires a ceux rapportes dans des etudes anterieures menees chez des femmes canadiennes. Si certaines femmes avaient un faible apport en vitamine D et en fer, la plupart avaient un apport eleve en folate et en vitamine [B.sub.12]. Ces resultats fournissent une indication pour assurer des apports alimentaires et en supplements appropries dans cette population potentiellement vulnerable et rarement etudiee. Mots-cles : anabaptiste, femmes enceintes post-partum, folate, vitamine [B.sub.12], vitamine D, fer. (Rev can prat rech dietet. 2024;85:149-156) (DOI: 10.3148/cjdpr-2024-003) Publie au dcjournal.ca le 12 aout 2024
Journal Article
Vitamin D, Folate, Vitamin B12, and Iron Status in Pregnant/Postpartum Old Order Anabaptist Women in Southwestern Ontario
Objectif. Évaluer le bilan en vitamine D, en folate, en vitamine B12 et en fer de femmes anabaptistes de l'Ancien Ordre (AAO) enceintes ou en post-partum. Méthodes. Des analyses sanguines ont été effectuées afin d'évaluer les taux de 25-hydroxyvitamine D (25(OH)D) plasmatique, de folate des globules rouges, de vitamine B12 sérique et de fer. Les apports alimentaires (aliments et suppléments) issus d'estimations sur 3 jours ont été comparés aux apports nutritionnels de référence et au Guide alimentaire canadien (2007). Résultats. Cinquante femmes ont participé à cette étude transversale descriptive. Les concentrations de 25(OH)D étaient faibles (<50 nmol/l pour 20 % et <75 nmol/l pour 63 %); 42 % avaient des apports totaux en vitamine D inférieurs au besoin moyen estimatif (BME). Toutes les femmes avaient un taux de folate dans les globules rouges supérieur au seuil de 1360 mmol/l. Dix-neuf pour cent avaient un apport en folate inférieur au BME; 80 % avaient un apport en suppléments d'acide folique supérieur à la limite supérieure. Une femme avait un taux de vitamine B12 sérique faible (<148 pmol/l); mais le taux de vitamine B12 sérique était élevé (>652 pmol/l) pour 24 % des femmes. Aucune n'avait un apport en vitamine B12 inférieur au BME; les apports étaient élevés comparativement à l'apport alimentaire recommandé. Une femme présentait un taux d'hémoglobine faible; 13 % avaient un taux de ferritine inférieur à 15 µg/l. Treize pour cent avaient un apport total en fer inférieur au BME. Conclusions. Dans l'ensemble, l'apport alimentaire et l'état nutritionnel en micronutriments sériques des femmes AAO enceintes et en post-partum de notre étude étaient similaires à ceux rapportés dans des études antérieures menées chez des femmes canadiennes. Si certaines femmes avaient un faible apport en vitamine D et en fer, la plupart avaient un apport élevé en folate et en vitamine B12. Ces résultats fournissent une indication pour assurer des apports alimentaires et en suppléments appropriés dans cette population potentiellement vulnérable et rarement étudiée.
Journal Article
Imputation for lipidomics and metabolomics (ImpLiMet): a web-based application for optimization and method selection for missing data imputation
NRC publication: Yes
Journal Article