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Private security forces such as campus police, security guards, loss prevention officers, and the like are not state actors covered by the Fourth Amendment's prohibition against unreasonable searches and seizures nor the Fifth Amendment's Miranda protections. As members of the umbrella category of \"private police,\" these private law enforcement agents often obtain evidence, detain individuals, and elicit confessions in a manner that government actors cannot, which can then be lawfully turned over to the government. Though the same statutory law governing private citizens (assault, false imprisonment, trespass, etc.) also regulates private police conduct, private police conduct is not bound by constitutional protections like the exclusionary rule, which requires that evidence obtained in violation of a criminal defendant's rights be excluded from their prosecution. As a result of this disparity, evidence that would have been suppressed if government actors had procured it is often deemed admissible when procured by private police. Because private actors make up a significant and growing sector of law enforcement, the absence of robust constitutional regulation means that citizens whose rights are violated have little recourse because the default remedy of suppression is unavailable. This Comment examines how states' exclusionary rules impose higher standards on searches and seizures than the federal exclusionary rule by encompassing private actors. It also urges Washington State to adopt an exclusionary rule that recognizes suppression of illegally obtained evidence from both public and private actors.

IL-33 is an epithelium-derived, pro-inflammatory alarmin with enigmatic nuclear localization and chromatin binding. Here we report the functional properties of nuclear IL-33. Overexpression of IL-33 does not alter global gene expression in transduced epithelial cells. Fluorescence recovery after photobleaching data show that the intranuclear mobility of IL-33 is ~10-fold slower than IL-1α, whereas truncated IL-33 lacking chromatin-binding activity is more mobile. WT IL-33 is more resistant to necrosis-induced release than truncated IL-33 and has a relatively slow, linear release over time after membrane dissolution as compared to truncated IL-33 or IL-1α. Lastly, IL-33 and histones are released as a high-molecular weight complex and synergistically activate receptor-mediated signaling. We thus propose that chromatin binding is a post-translational mechanism that regulates the releasability and ST2-mediated bioactivity of IL-33 and provide a paradigm to further understand the enigmatic functions of nuclear cytokines. Interleukin-33 (IL-33) can be released as a cytokine or transported into the nucleus, but the significance of this nuclear shuttling is not fully understood. Here the authors show that chromatin-binding of IL-33 alters, unexpectedly, the activity of IL-33 both in alarmin release kinetics and receptor signaling capacity.

This paper is a technical overview of DeepMind and Google's recent work on reinforcement learning for controlling commercial cooling systems. Building on expertise that began with cooling Google's data centers more efficiently, we recently conducted live experiments on two real-world facilities in partnership with Trane Technologies, a building management system provider. These live experiments had a variety of challenges in areas such as evaluation, learning from offline data, and constraint satisfaction. Our paper describes these challenges in the hope that awareness of them will benefit future applied RL work. We also describe the way we adapted our RL system to deal with these challenges, resulting in energy savings of approximately 9% and 13% respectively at the two live experiment sites.