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"Rottmann, Jennifer"
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Reconsidering Canadian curriculum studies : provoking historical, present, and future perspectives
\"Reconsidering Canadian Curriculum Studies is a thought-provoking book, where curriculum scholars at different stages in their academic careers experiment with innovating theoretical and methodological ways to research the concept of \"curriculum.\" Each chapter showcases examples of the dynamic intellectual work being done within the international field of curriculum studies across the diverse geographical and cultural regions here in Canada and the United States. In this book, the authors provoke us to ask more of curriculum studies in relation to other fields of study like environmental education, anti-racist education, multicultural education, internationalization, indigenousness, cultural studies, cultural geography, interdisciplinary studies, phenomenology, hermeneutics, and poststructuralism. This book is an excellent introductory text for any curriculum studies course either here in Canada or abroad\"-- Provided by publisher.
Book
Saltwater Chronicles: Reading Representational Spaces in Selected Book Clubs in St. John’s, Newfoundland
Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration in which the lived, loved, and experiential dimensions of literary space come to invoke the permeability of psychic and geographic borders, the dangers and possibilities of the landwash, and the always-already precarious designation of limits between self and other. We provide examples of how, for these island readers, “islandness” as a symbolic point of address slips and border-crosses in the in-between semiotic spaces of literary encounter.
Journal Article
Saltwater Chronicles: reading representational spaces in selected book clubs in St. John's, Newfoundland
Saltwater Chronicles investigates the notion of “islandness” in contemporary Newfoundland readership through two in-depth case studies of book clubs as representational spaces in the elaboration of local knowledge and identities. We demonstrate how select Newfoundland readers perform acts of regeneration in which the lived, loved, and experiential dimensions of literary space come to invoke the permeability of psychic and geographic borders, the dangers and possibilities of the landwash, and the always-already precarious designation of limits between self and other. We provide examples of how, for these island readers, “islandness” as a symbolic point of address slips and border-crosses in the in-between semiotic spaces of literary encounter.
Journal Article
More Sympathetic View Might Be the Answer
I do not know what it is like to grow up with a childhood that is \"a living hell,\" as Kathy Carney writes in her letter to the Editor [\"Homeless Should Help Themselves,\" District Extra, Aug. 2] although almost all of my homeless friends do. Although her bitterness toward...
Newspaper Article
Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies
Ψ-1,4-naphthoquinones (Ψ-NQ) are non-quinoid compounds in which aromaticity—found in 1,4-naphthoquinones—is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs of 1,4-naphthoquinones in an oxidative environment. Furthermore, from a medicinal chemistry point of view, the loss of planarity of the scaffold might lead to an improved solubility and circumvent the bad reputation of quinones in the pharmaceutical industry. In this work, we illustrated the concept by the synthesis of Ψ -plasmodione regioisomers as prodrugs of the antimalarial plasmodione. The presence of a chiral center introduces a new degree of freedom to be controlled by enantioselectivity and regioselectivity of the cycloaddition in the Diels–Alder reaction. The first strategy that was followed was based on the use of a chiral enantiopure sulfoxide to govern the stereoselective formation of (+)Ψ-NQ or (−)Ψ-NQ, depending on the chirality of the sulfoxide (R or S). New sulfinylquinones were synthesized but were found to be ineffective in undergoing cycloaddition with different dienes under a wide range of conditions (thermal, Lewis acid). The second strategy was based on the use of boronic acid-substituted benzoquinones as auxiliaries to control the regioselectivity. Using this methodology to prepare the (±)Ψ-NQ racemates, promising results (very fast cycloaddition time: ~2 h) were obtained with boronic acid-based quinones 25 and 27 in the presence of 1-methoxy-1,3-butadiene, to generate the 4a- and the 8a-Ψ-plasmodione regioisomers 1 and 2 (synthesized in six steps with a total yield of 10.5% and 4.1%, respectively. As the expected prodrug effect can only be revealed if the molecule undergoes an oxidation of the angular methyl, e.g., in blood-feeding parasites that digest hemoglobin from the host, the antimalarial and the antischistosomal properties of both (±)Ψ-NQ regioisomers were determined in drug assays with Plasmodium falciparum and Schistosoma mansoni. Metabolic studies under quasi-physiological conditions and LC-MS analyses were undertaken to reveal the generation of plasmodione from both the 4a- and the 8a-Ψ-plasmodione regioisomers.
Journal Article
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage Plasmodium falciparum and Cryptosporidium parvum in cell-culture studies. Target deconvolution in P. falciparum has shown that cladosporin inhibits lysyl-tRNA synthetase (PfKRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both PfKRS1 and C. parvum KRS (CpKRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED90 = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between PfKRS1 and CpKRS. This series of compounds inhibit CpKRS and C. parvum and Cryptosporidium hominis in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for PfKRS1 and CpKRS vs. (human) HsKRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis.
Journal Article