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Background Protein methylation, a post-translational modification, is crucial in regulating various cellular functions. Arginine methylation is required to understand crucial biochemical activities and biological functions, like gene regulation, signal transduction, etc. However, some experimental methods, including Chip–Chip, mass spectrometry, and methylation-specific antibodies, exist for the prediction of methylated proteins. These experimental methods are expensive and tedious. As a result, computational methods based on machine learning play an efficient role in predicting arginine methylation sites. Results In this research, a novel method called PRMxAI has been proposed to predict arginine methylation sites. The proposed PRMxAI extract sequence-based features, such as dipeptide composition, physicochemical properties, amino acid composition, and information theory-based features (Arimoto, Havrda-Charvat, Renyi, and Shannon entropy), to represent the protein sequences into numerical format. Various machine learning algorithms are implemented to select the better classifier, such as Decision trees, Naive Bayes, Random Forest, Support vector machines, and K-nearest neighbors. The random forest algorithm is selected as the underlying classifier for the PRMxAI model. The performance of PRMxAI is evaluated by employing 10-fold cross-validation, and it yields 87.17% and 90.40% accuracy on mono-methylarginine and di-methylarginine data sets, respectively. This research also examines the impact of various features on both data sets using explainable artificial intelligence. Conclusions The proposed PRMxAI shows the effectiveness of the features for predicting arginine methylation sites. Additionally, the SHapley Additive exPlanation method is used to interpret the predictive mechanism of the proposed model. The results indicate that the proposed PRMxAI model outperforms other state-of-the-art predictors.

This work proposes a facial expression recognition system for a diversified field of applications. The purpose of the proposed system is to predict the type of expressions in a human face region. The implementation of the proposed method is fragmented into three components. In the first component, from the given input image, a tree-structured part model has been applied that predicts some landmark points on the input image to detect facial regions. The detected face region was normalized to its fixed size and then down-sampled to its varying sizes such that the advantages, due to the effect of multi-resolution images, can be introduced. Then, some convolutional neural network (CNN) architectures were proposed in the second component to analyze the texture patterns in the facial regions. To enhance the proposed CNN model’s performance, some advanced techniques, such data augmentation, progressive image resizing, transfer-learning, and fine-tuning of the parameters, were employed in the third component to extract more distinctive and discriminant features for the proposed facial expression recognition system. The performance of the proposed system, due to different CNN models, is fused to achieve better performance than the existing state-of-the-art methods and for this reason, extensive experimentation has been carried out using the Karolinska-directed emotional faces (KDEF), GENKI-4k, Cohn-Kanade (CK+), and Static Facial Expressions in the Wild (SFEW) benchmark databases. The performance has been compared with some existing methods concerning these databases, which shows that the proposed facial expression recognition system outperforms other competing methods.

A deep fusion model is proposed for facial expression-based human-computer Interaction system. Initially, image preprocessing, i.e., the extraction of the facial region from the input image is utilized. Thereafter, the extraction of more discriminative and distinctive deep learning features is achieved using extracted facial regions. To prevent overfitting, in-depth features of facial images are extracted and assigned to the proposed convolutional neural network (CNN) models. Various CNN models are then trained. Finally, the performance of each CNN model is fused to obtain the final decision for the seven basic classes of facial expressions, i.e., fear, disgust, anger, surprise, sadness, happiness, neutral. For experimental purposes, three benchmark datasets, i.e., SFEW, CK+, and KDEF are utilized. The performance of the proposed system is compared with some state-of-the-art methods concerning each dataset. Extensive performance analysis reveals that the proposed system outperforms the competitive methods in terms of various performance metrics. Finally, the proposed deep fusion model is being utilized to control a music player using the recognized emotions of the users.

Aldehyde dehydrogenase 2 (ALDH2) enzyme is required for alcohol detoxification. ALDH2 belongs to the aldehyde dehydrogenase family, the most important oxidative pathway of alcohol digestion. Two main liver isoforms of aldehyde dehydrogenase are cytosolic and mitochondrial. Approximately 50% of East Asians have ALDH2 deficiency (inactive mitochondrial isozyme), with lysine (K) for glutamate (E) substitution at position 487 (E487K). ALDH2 deficiency is also known as Alcohol Flushing Syndrome or Asian Glow. For people with an ALDH2 deficiency, their face turns red after drinking alcohol, and they are more susceptible to various diseases than ALDH2-normal people. This study performed a machine learning analysis of ALDH2 sequences of thirteen other species by comparing them with the human ALDH2 sequence. Based on the various quantitative metrics (physicochemical properties, secondary structure, Hurst exponent, Shannon entropy, and fractal dimension), these fourteen species were clustered into four clusters using the unsupervised machine learning (K-means clustering) algorithm. We also analyze these species using hierarchical clustering (agglomerative clustering) and draw the phylogenetic trees. The results show that Homo sapiens is more closely related to the Bos taurus and Sus scrofa species. Our experimental results suggest that the testing for discovering medicines may be done on these species before being tested in humans to alleviate the impacts of ALDH2 deficiency.

Multi-focus image fusion (MIF) uses fusion rules to combine two or more images of the same scene with various focus values into a fully focused image. An all-in-focus image refers to a fully focused image that is more informative and useful for visual perception. A fused image with high quality is essential for maintaining shift-invariant and directional selectivity characteristics of the image. Traditional wavelet-based fusion methods, in turn, create ringing distortions in the fused image due to a lack of directional selectivity and shift-invariance. In this paper, a classical MIF system based on quarter shift dual-tree complex wavelet transform (qshiftN DTCWT) and modified principal component analysis (MPCA) in the laplacian pyramid (LP) domain is proposed to extract the focused image from multiple source images. In the proposed fusion approach, the LP first decomposes the multi-focus source images into low-frequency (LF) components and high-frequency (HF) components. Then, qshiftN DTCWT is used to fuse low and high-frequency components to produce a fused image. Finally, to improve the effectiveness of the qshiftN DTCWT and LP-based method, the MPCA algorithm is utilized to generate an all-in-focus image. Due to its directionality, and its shift-invariance, this transform can provide high-quality information in a fused image. Experimental results demonstrate that the proposed method outperforms many state-of-the-art techniques in terms of visual and quantitative evaluations.

Coronaviruses are responsible for various diseases ranging from the common cold to severe infections like the Middle East syndromes and the severe acute respiratory syndrome. However, a new coronavirus strain known as COVID-19 developed into a pandemic resulting in an ongoing global public health crisis. Therefore, there is a need to understand the genomic transformations that occur within this family of viruses in order to limit disease spread and develop new therapeutic targets. The nucleotide sequences of SARS-CoV-2 are consist of several bases. These bases can be classified into purines and pyrimidines according to their chemical composition. Purines include adenine (A) and guanine (G), while pyrimidines include cytosine (C) and tyrosine (T). There is a need to understand the spatial distribution of these bases on the nucleotide sequence to facilitate the development of antivirals (including neutralizing antibodies) and epitomes necessary for vaccine development. This study aimed to evaluate all the purine and pyrimidine associations within the SARS-CoV-2 genome sequence by measuring mathematical parameters including; Shannon entropy, Hurst exponent, and the nucleotide guanine-cytosine content. The Shannon entropy is used to identify closely associated sequences. Whereas Hurst exponent is used to identifying the auto-correlation of purine-pyrimidine bases even if their organization differs. Different frequency patterns can be used to determine the distribution of all four proteins and the density of each base. The GC-content is used to understand the stability of the DNA. The relevant genome sequences were extracted from the National Center for Biotechnology Information (NCBI) virus database. Furthermore, the phylogenetic properties of the COVID-19 virus were characterized to compare the closeness of the COVID-19 virus with other coronaviruses by evaluating the purine and pyrimidine distribution.

Air collection around the lung regions can cause lungs to collapse. Conditions like emphysema can cause chronic obstructive pulmonary disease (COPD), wherein lungs get progressively damaged, and the damage cannot be reversed by treatment. It is recommended that these conditions be detected early via highly complex image processing models applied to chest X-rays so that the patient’s life may be extended. Due to COPD, the bronchioles are narrowed and blocked with mucous, and causes destruction of alveolar geometry. These changes can be visually monitored via feature analysis using effective image classification models such as convolutional neural networks (CNN). CNNs have proven to possess more than 95% accuracy for detection of COPD conditions for static datasets. For consistent performance of CNNs, this paper presents an incremental learning mechanism that uses deep transfer learning for incrementally updating classification weights in the system. The proposed model is tested on 3 different lung X-ray datasets, and an accuracy of 99.95% is achieved for detection of COPD. In this paper, a model for temporal analysis of COPD detected imagery is proposed. This model uses Gated Recurrent Units (GRUs) for evaluating lifespan of patients with COPD. Analysis of lifespan can assist doctors and other medical practitioners to take recommended steps for aggressive treatment. A smaller dataset was available to perform temporal analysis of COPD values because patients are not advised continuous chest X-rays due to their long-term side effects, which resulted in an accuracy of 97% for lifespan analysis.

In this paper, a unique facial expression recognition system has been proposed. The objective of this paper is to identify the type of human facial expression and to improve the performance by incorporating different variant patterns present in facial images. In literature, the use of different patterns of the human face has not yet been employed in its full swing. In our proposed method, this gap has been overcome by fusing a data augmentation in the preprocessing step and an optimized weight in the deep CNN model at the feature extraction step. To make this proposed model noise-free, we focus on the feature extraction method rather than designing a complex model to decompose a set of feature vectors into expression-specific feature vectors. Here, to analyze the performance of FER system, we use cultural difference datasets in both laboratory controlled and wild environments. To develop a precise facial expression recognition system, we propose an invariant deep convolutional neural network (DCNN) model that learns from all image variants to improve performance. Our model also induces a new pipeline strategy to correlate a preprocessing and feature extraction step in an optimized way. Experiments on laboratory and wild-controlled datasets show that our FER system attains a more significant performance than other state-of-the-art models due to its ability to utilize all the different variant patterns present in the facial image.

Parkinson’s disease is related to nervous system disorders in human beings. In this paper, the status of Parkinson’s disease has been predicted based on the analysis of features of two Parkinson’s disease symptoms: Dysphonia and Dysarthria. The Dysphonia symptom has been measured by analyzing the features extracted from the vocal sounds of a patient. The Dysarthria symptom of Parkinson’s disease has been analyzed by the features extracted from the speech signals of a patient. Hence, two different prediction models have been built for deriving the status of Parkinson’s disease. The derivation of these prediction systems is based on statistical and discriminant feature analysis. The statistical-based feature analysis is carried out using descriptive and inferential analysis. In contrast, the enteric, deviation, and correlation-based information between the features are utilized for descriptive analysis. The inferential analysis has been performed using hypothetical testing of the distribution of features. The descriptive and inferential feature analyses are used to derive effective features for the Parkinson’s disease problem based on the Dysphonia and Dysarthria symptoms. In the discriminant feature analysis, the feature sets undergo deriving discriminant features. The best-selected features are used to build a prediction model for detecting Parkinson’s disease problems in a patient. Extensive experimentation has been carried out using a Dysphonia dataset containing 195 samples. Each sample has 23 features. One dataset for Dysarthria symptoms contains 756 observations, with each observation having 754 features. The best prediction models that have been obtained correspond to these datasets, and 93.50% is obtained for Dysphonia and 87.63% for Dysarthria symptoms databases, respectively. The performance of the proposed system has been compared with some existing methods concerning each employed dataset, showing the superiority of the proposed approach.

A novel facial expression recognition system has been proposed in this paper. The objective of this paper is to recognize the types of expressions in the human face region. The implementation of the proposed system has been divided into four components. In the first component, a region of interest as face detection has been performed from the captured input image. For extracting more distinctive and discriminant features, in the second component, a deep learning-based convolutional neural network architecture has been proposed to perform feature learning tasks for classification purposes to recognize the types of expressions. To enhance the performance of the proposed system, in the third component, some novel data augmentation techniques have been applied to the facial image to enrich the learning parameters of the proposed CNN model. In the fourth component, a trade-off between data augmentation and deep learning features have been performed for fine-tuning the trained CNN model. Extensive experimental results have been demonstrated using three benchmark databases: KDEF (seven expression classes), GENKI-4k (two expression classes), and CK+ (seven expression classes). The performance of the proposed system respect for each database has been well presented and described and finally, these performances have been compared with the existing state-of-the-art methods. The comparison with competing methods shows the superiority of the proposed system.