Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
34
result(s) for
"Rowell, Sarah"
Sort by:
Achieving excellence in high performance sport : experiences and skills behind the medals
\"What does it take for a person starting out in their career to succeed in a highly challenging environment? Apart from the technical skills, what are the key values, attitudes and behaviours that deliver outstanding performance in a constantly changing, unpredictable and demanding world?\"Achieving Excellence in High Performance Sport\" examines these questions within the exacting world of elite sport: a global stage that places the severest pressures not only on the dedicated athletes, but also on the vital talent of coaches, sport scientists and sport medicine practitioners.\"--P. [4] cover.
Book
Semi-quantitative, high throughput analysis of SARS-CoV-2 neutralizing antibodies: Measuring the level and duration of immune response antibodies post infection/vaccination
The question associated with efficacy and longevity of SARS-CoV-2 protection post-vaccination is paramount. The cPass surrogate virus neutralization test (sVNT) has gained popularity globally as a dual application assay for: 1. Accurate SARS-CoV-2 population surveillance (seroprevalence) analysis and 2. Revealing the presence of antibodies that block and effectively neutralize the interaction between the SARS-CoV-2 receptor binding domain and the host cell ACE2 receptor in recovered or vaccinated individuals. This study describes an approach for accurate quantification of neutralizing antibodies using the cPass sVNT with an automated workflow on the Tecan EVO and Dynex Agility platforms that is applicable to other liquid handling systems. This methodology was used to assess the stability of SARS-CoV-2 neutralizing antibodies between freeze/thaw and refrigerated sample storage conditions. Furthermore, a subset of twenty-five samples from SARS-CoV-2 infected/recovered individuals revealed a 600-fold difference in the neutralizing antibody response where low titers were represented in about half of the samples. Finally, pre- and post-vaccination samples were tested for neutralizing antibodies using the qualitative and semi-quantitative cPass sVNT protocols revealing undetectable or relatively low levels after the first vaccine dose and a decline in levels longitudinally over the months following the second dose. This wide range in neutralizing (blocking) antibodies from both natural infection and vaccination supports a differential immune response that may be attributed to several physiological and genetic factors underlining the potential for measuring SARS-CoV-2 neutralizing antibody titer levels post-vaccination to help ensure robust and prolonged immunity.
Journal Article
Pumpkinheads : a graphic novel
\"Deja and Josiah are seasonal best friends. Every autumn, all through high school, they've worked together at the best pumpkin patch in the whole wide world. (Not many people know that the best pumpkin patch in the whole wide world is in Omaha, Nebraska, but it definitely is.) They say good-bye every Halloween, and they're reunited every September 1. But this Halloween is different -- Josiah and Deja are finally seniors, and this is their last season at the pumpkin patch. Their last shift together. Their last good-bye. Josiah's ready to spend the whole night feeling melancholy about it. Deja isn't ready to let him. She's got a plan: What if -- instead of moping and the usual slinging lima beans down at the Succotash Hut -- they went out with a bang? They could see all the sights! Taste all the snacks! And Josiah could finally talk to that cute girl he's been mooning over for three years ... What if their last shift was an adventure? Beloved writer Rainbow Rowell and Eisner Award-winning artist Faith Erin Hicks have teamed up to create this tender and hilarious story about two irresistible teens discovering what it means to leave behind a place -- and a person -- with no regrets.\"-- Amazon.com.
Book
The Kaiser Permanente Research Bank Cancer Cohort: a collaborative resource to improve cancer care and survivorship
Background
The Kaiser Permanente Research Bank (KPRB) is collecting biospecimens and surveys linked to electronic health records (EHR) from approximately 400,000 adult KP members. Within the KPRB, we developed a Cancer Cohort to address issues related to cancer survival, and to understand how genetic, lifestyle and environmental factors impact cancer treatment, treatment sequelae, and prognosis. We describe the Cancer Cohort design and implementation, describe cohort characteristics after 5 years of enrollment, and discuss future directions.
Methods
Cancer cases are identified using rapid case ascertainment algorithms, linkage to regional or central tumor registries, and direct outreach to KP members with a history of cancer. Enrollment is primarily through email invitation. Participants complete a consent form, survey, and donate a blood or saliva sample. All cancer types are included.
Results
As of December 31, 2020, the cohort included 65,225 cases (56% female, 44% male) verified in tumor registries. The largest group was diagnosed between 60 and 69 years of age (31%) and are non-Hispanic White (83%); however, 10,076 (16%) were diagnosed at ages 18–49 years, 4208 (7%) are Hispanic, 3393 (5%) are Asian, and 2389 (4%) are Black. The median survival time is 14 years. Biospecimens are available on 98% of the cohort.
Conclusions
The KPRB Cancer Cohort is designed to improve our understanding of treatment efficacy and factors that contribute to long-term cancer survival. The cohort’s diversity - with respect to age, race/ethnicity and geographic location - will facilitate research on factors that contribute to cancer survival disparities.
Journal Article
Excess maternal transmission of type 2 diabetes: The Northern California Kaiser Permanente Diabetes Registry
Excess maternal transmission of type 2 diabetes. The Northern California Kaiser Permanente Diabetes Registry.
A J Karter ,
S E Rowell ,
L M Ackerson ,
B D Mitchell ,
A Ferrara ,
J V Selby and
B Newman
Division of Research, Kaiser Permanente, Oakland, California 94611-5714, USA. ajk@dor.kaiser.org
Abstract
OBJECTIVE: To assess excess maternal transmission of type 2 diabetes in a multiethnic cohort. Previous studies have reported
higher prevalence of diabetes among mothers of probands with type 2 diabetes than among fathers. This analysis is vulnerable
to biases, and this pattern has not been observed in all populations or races. RESEARCH DESIGN AND METHODS: We assessed evidence
for excess maternal transmission among 42,533 survey respondents with type 2 diabetes (probands) by calculating the prevalence
of diabetes in their siblings and offspring. To assess data quality, we evaluated completeness of family history data provided.
Accuracy of family information reported by probands was also evaluated by comparing survey responses in a subsample of 206
probands with family histories modified after further interviews with relatives. RESULTS: Siblings (n = 60,532) of probands
with affected mothers had a greater prevalence of diabetes (20%) than those with affected fathers (17%) (P < 0.001 for adjusted
odds ratios). Prevalence of diabetes was higher among the offspring (n = 72,087) of female (3.4%) versus male (2.2%) probands
(P < 0.001 for adjusted odds ratios). These patterns were evident in all races and both sexes; however, the effect size was
clinically insignificant in African-Americans and male offspring. In general, probands provided more complete data about diabetes
status for the maternal arm of the pedigree than the paternal arm. Completeness of knowledge was not related to proband sex,
but was related to education and race, and inversely to age. Accuracy of proband-reported family history was consistently
good (kappa statistics generally > 0.70). CONCLUSIONS: Excess maternal transmission was observed in all races and both sexes,
although the size of the excess was negligible in African-Americans and male offspring. Potential reporting and censoring
biases are discussed.
Journal Article
Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
Using genome-wide genotypes, we characterized the genetic structure of 103,006 participants in the Kaiser Permanente Northern California multi-ethnic Genetic Epidemiology Research on Adult Health and Aging Cohort and analyzed the relationship to self-reported race/ethnicity. Participants endorsed any of 23 race/ethnicity/nationality categories, which were collapsed into seven major race/ethnicity groups. By self-report the cohort is 80.8% white and 19.2% minority; 93.8% endorsed a single race/ethnicity group, while 6.2% endorsed two or more. Principal component (PC) and admixture analyses were generally consistent with prior studies. Approximately 17% of subjects had genetic ancestry from more than one continent, and 12% were genetically admixed, considering only nonadjacent geographical origins. Self-reported whites were spread on a continuum along the first two PCs, indicating extensive mixing among European nationalities. Self-identified East Asian nationalities correlated with genetic clustering, consistent with extensive endogamy. Individuals of mixed East Asian–European genetic ancestry were easily identified; we also observed a modest amount of European genetic ancestry in individuals self-identified as Filipinos. Self-reported African Americans and Latinos showed extensive European and African genetic ancestry, and Native American genetic ancestry for the latter. Among 3741 genetically identified parent–child pairs, 93% were concordant for self-reported race/ethnicity; among 2018 genetically identified full-sib pairs, 96% were concordant; the lower rate for parent–child pairs was largely due to intermarriage. The parent–child pairs revealed a trend toward increasing exogamy over time; the presence in the cohort of individuals endorsing multiple race/ethnicity categories creates interesting challenges and future opportunities for genetic epidemiologic studies.
Journal Article
Automated Assay of Telomere Length Measurement and Informatics for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort
The Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort includes DNA specimens extracted from saliva samples of 110,266 individuals. Because of its relationship to aging, telomere length measurement was considered an important biomarker to develop on these subjects. To assay relative telomere length (TL) on this large cohort over a short time period, we created a novel high throughput robotic system for TL analysis and informatics. Samples were run in triplicate, along with control samples, in a randomized design. As part of quality control, we determined the within-sample variability and employed thresholds for the elimination of outlying measurements. Of 106,902 samples assayed, 105,539 (98.7%) passed all quality control (QC) measures. As expected, TL in general showed a decline with age and a sex difference. While telomeres showed a negative correlation with age up to 75 years, in those older than 75 years, age positively correlated with longer telomeres, indicative of an association of longer telomeres with more years of survival in those older than 75. Furthermore, while females in general had longer telomeres than males, this difference was significant only for those older than age 50. An additional novel finding was that the variance of TL between individuals increased with age. This study establishes reliable assay and analysis methodologies for measurement of TL in large, population-based human studies. The GERA cohort represents the largest currently available such resource, linked to comprehensive electronic health and genotype data for analysis.
Journal Article
Exclusive Interview with Sarah Rowell, CEO, Kantola Training Solutions
In an exclusive interview with HR.com, Sarah Rowell, CEO of Kantola Training Solutions, talks about the current state of DEI & more. Featured in March 2022 Edition of Talent Management Excellence
Magazine Article
Decoding human fetal liver haematopoiesis
Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in humans. Here, using single-cell transcriptome profiling of approximately 140,000 liver and 74,000 skin, kidney and yolk sac cells, we identify the repertoire of human blood and immune cells during development. We infer differentiation trajectories from HSC/MPPs and evaluate the influence of the tissue microenvironment on blood and immune cell development. We reveal physiological erythropoiesis in fetal skin and the presence of mast cells, natural killer and innate lymphoid cell precursors in the yolk sac. We demonstrate a shift in the haemopoietic composition of fetal liver during gestation away from being predominantly erythroid, accompanied by a parallel change in differentiation potential of HSC/MPPs, which we functionally validate. Our integrated map of fetal liver haematopoiesis provides a blueprint for the study of paediatric blood and immune disorders, and a reference for harnessing the therapeutic potential of HSC/MPPs.
Single-cell transcriptomic profiling of fetal liver, skin, kidney and yolk sac reveals the differentiation trajectories of human haematopoietic stem cells and multipotent progenitors, which are validated to produce an integrated map of fetal liver haematopoiesis.
Journal Article