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The continuous casting process (CCP) is the most vital part of steelmaking. The flow pattern near the submerged entry nozzle (SEN) and mould greatly influence the quality of the slab produced. The present investigation was carried out to gain knowledge regarding the meniscus fluctuation under different nozzle port blockage conditions by water model experiments. The experiments were carried out to study the effect of no blockage, 25% blockage, 50% blockage, and 75% blockage of the nozzle port on mould-level fluctuations. The result shows that when the liquid flow rate increases, the wave amplitude increases. In these experiments, the average and maximum meniscus fluctuations were measured while changing different variables such as the water flow rate, gas flow rate, and one-side percentage blockage of the SEN port while the other side was fully open. The observation shows that when the port size decreases, the fluid steel mixed from the obstructing side to the open side results in asymmetry. The average and maximum wave amplitude increases with decreasing submergence depth. It was observed that the maximum height of the standing waves in the mould continued rising on the non-blocked side of the SEN. Blockage increases from 25% to 75%, and with 75% blockage of the right side of the SEN port, the mould-level fluctuation at the left side of the mould was extreme, while that of the right side was relatively quiet.

Industrial effluent containing textile dyes is regarded as a major environmental concern in the present world. Crystal Violet is one of the vital textile dyes of the triphenylmethane group; it is widely used in textile industry and known for its mutagenic and mitotic poisoning nature. Bioremediation, especially through bacteria, is becoming an emerging and important sector in effluent treatment. This study aimed to isolate and identify Crystal Violet degrading bacteria from industrial effluents with potential use in bioremediation. The decolorizing activity of the bacteria was measured using a photo electric colorimeter after aerobic incubation in different time intervals of the isolates. Environmental parameters such as pH, temperature, initial dye concentration and inoculum size were optimized using mineral salt medium containing different concentration of Crystal Violet dye. Complete decolorizing efficiency was observed in a mineral salt medium containing up to 150 mg/l of Crystal Violet dye by 10% (v/v) inoculums of Enterobacter sp. CV–S1 tested under 72 h of shaking incubation at temperature 35 °C and pH 6.5. Newly identified bacteria Enterobacter sp. CV–S1, confirmed by 16S ribosomal RNA sequencing, was found as a potential bioremediation biocatalyst in the aerobic degradation/de-colorization of Crystal Violet dye. The efficiency of degrading triphenylmethane dye by this isolate, minus the supply of extra carbon or nitrogen sources in the media, highlights the significance of larger-scale treatment of textile effluent.

An experimental investigation has been carried out to analyse different mould section sizes to measure the meniscus fluctuation by varying different liquid flow rates and different submerged entry nozzle port angles, i.e., 0° port angles, 15° downward and 15° upward port angles. The terms of maximum surface wave fluctuation and standard deviation have been analysed for the above mentioned parameters. It was observed that a submerged entry nozzle with 0° port was found to be superior when it was compared with a 15° downward and 15° upward port nozzle. By conducting an experiment, it was observed that as the water flow rate increased, the maximum wave amplitude was found to be increasing, which results in more turbulence. Different mould section sizes were analysed to provide background information to the steelmaker to analyse the behaviour of fluid flow pattern. The operating parameters of the result obtained from the present setup were compared with the published literature, and a scale down of slab moulds can be justifiedregarding the rough flow pattern in the mould but can lack accuracy. The reason behind this statement is that the integral length scales of the turbulent flow between scaled down and full scale models can be different. Therefore, details of the flow pattern can become great differences between both types of models.

Lead (Pb) induces neurotoxicity in both children and adults. Children are more vulnerable to Pb toxicity than adults. Little is known about the effects of Pb on the mental health of the children who are prenatally exposed. Therefore, we designed an animal experiment to compare the adverse effects of Pb on neurobehavioral and hepatic functions between Pb-exposed (Pb mice) and parental Pb-exposed (P-Pb mice) group mice. Mice were treated with Pb-acetate (10 mg/kg bodyweight/day) via drinking water. Male mice from unexposed parents treated with Pb for 90 days were defined as Pb mice, whereas male mice from Pb-exposed parents treated with Pb for further 90 days were defined as P-Pb mice. Anxiety-like behavior and spatial memory and learning were assessed by elevated plus maze and Morris water maze. Serum hepatic enzyme activities and butyrylcholinesterase activity were measured by an analyzer. P-Pb mice displayed increased anxiety-like behavior and memory and learning impairments compared to Pb mice. BChE activity was significantly decreased in P-Pb mice compared to Pb mice. Pb levels in the brains of P-Pb mice were significantly higher than those of Pb mice. The activities of serum hepatic enzymes of P-Pb mice were also higher than those of Pb mice. Additionally, histopathology data revealed that hepatic tissue injury was more pronounced in P-Pb mice than in Pb mice. Thus, the results suggest that persistent exposure to Pb from fetus to adult causes more severe neurobehavioral changes and hepatic toxicities than adult exposure only.

Groundwater used for drinking has been contaminated with naturally occurring inorganic arsenic and other metals, and metal-contaminated drinking water is the biggest threat to public health in Bangladesh. Toxic metals present in the drinking water have a strong relationship with chronic diseases in humans. Antimony (Sb), a naturally occurring metal, has been reported to be present in the drinking water along with other heavy metals in Bangladesh. Although Sb is present in the environment, very little attention has been given to the toxic effects of Sb. The present study was designed to investigate the in vivo effects of Sb on neurobehavioral changes like anxiety, learning and memory impairment, and blood indices related to organ dysfunction. Mice exposed to antimony potassium-tartrate hydrate (Sb) (10 mg/kg body weight) significantly (p < 0.05) decreased the time spent in open arms while increased the time spent in closed arms compared to the control mice in elevated plus maze. The mean latency time of control group to find the platform decreased (p < 0.05) significantly during 7 days learning as compared to Sb-treated group in Morris water maze test, and Sb-exposed group spent significantly (p < 0.05) less time in the desired quadrant as compared to the control group in probe trial. Sb treatment also significantly altered blood indices related to liver and kidney dysfunction. Additionally, Sb-induced biochemical alterations were associated with significant perturbations in histological architecture of liver and kidney of Sb-exposed mice. These data suggest that Sb has a toxic effect on neurobehavioral and biochemical changes in mice.

The mixed flow pump is a cross between the axial and radial flow pump. These pumps are used in a large number of applications in modern fields. For the designing of these mixed flow pump impeller blades, a lot number of design parameters are needed to be considered which makes this a tedious task for which fundamentals of turbo-machinery and fluid mechanics are always prerequisites. The semi-cone angle of mixed flow pump impeller blade has a specified range of variations generally between 45o to 60o. From the literature review done related to this topic researchers have considered only a particular semi-cone angle and all the calculations are based on this very same semi-cone angle. By varying this semi-cone angle in the specified range, it can be verified if that affects the designing of the impeller blades for a mixed flow pump. Although a lot of methods are available for designing of mixed flow pump impeller blades like inverse time marching method, the pseudo-stream function method, Fourier expansion singularity method, free vortex method, mean stream line theory method etc. still the optimized design of the mixed flow pump impeller blade has been a cumbersome work. As stated above since all the available research works suggest or propose the blade designs with constant semi-cone angle, here the authors have designed the impeller blades by varying the semi-cone angle in a particular range with regular intervals for a Mixed-Flow pump. Henceforth several relevant impeller blade designs are obtained and optimization is carried out to obtain the optimized design (blade with optimal geometry) of impeller blade.

The grain structure deforms once a material is subjected to rolling and due to the same the properties get affected especially the thermal properties resulting in orthotropic thermo-physical property. So, for a high hardness material for example, Ti–6Al–4 V requires extensive study as these are exclusively used as replacement in human body like, implants. The study also ensures proper fitment and longevity. Now, since a considerable quantity of heat is generated while machining of these materials hence, to formulate the cooling strategy, deep understanding of the temperature – distribution becomes very essential. Moreover, it also controls the thermo–physical characteristics of the aforesaid hard materials. The present work numerically estimates the temperature distribution assuming 2D material domain. To achieve the objective, Finite Difference Scheme has been used using Python. The mathematical equations relevant to heat transfer along with relevant boundary conditions have been discretized and iterative method has been employed for the solution. The various thermo–physical properties have been explicitly depicted with the aid of 2D temperature distribution plots. The conclusion of the work can be employed for deciding the cooling strategies and also various machining parameters. Graphical abstract

Bacillary dysentery is a type of dysentery and a severe form of shigellosis. This dysentery is usually restricted to Shigella infection, but Salmonella enterica and enteroinvasive Escherichia coli strains are also known as this infection’s causative agents. The emergence of drug-resistant, bacillary dysentery-causing pathogens is a global burden, especially for developing countries with poor hygienic environments. This study aimed to isolate, identify, and determine the drug-resistant pattern of bacillary dysentery-causing pathogens from the stool samples of the Kushtia region in Bangladesh. Hence, biochemical tests, serotyping, molecular identification, and antibiotic profiling were performed to characterize the pathogens. Among one hundred fifty (150) stool samples, 18 enteric bacterial pathogens were isolated and identified, where 12 were Shigella strains, 5 were S. enterica sub spp. enterica strains and one was the E.coli strain. Among 12 Shigella isolates, 8 were Shigella flexneri 2a serotypes, and 4 were Shigella sonnei Phage-II serotypes. Except for three Salmonella strains, all isolated strains were drug-resistant (83%), whereas 50% were multidrug-resistant (MDR), an alarming issue for public health. In antibiotic-wise analysis, the isolated pathogens showed the highest resistance against nalidixic acid (77.78%), followed by tetracycline (38.89%), kanamycin (38.89%), amoxicillin (27.78%), streptomycin (27.78%), cefepime (22.22%), ceftriaxone (22.22%), ampicillin (16.67%), ciprofloxacin (16.67%), and chloramphenicol (16.67%). The existence of MDR organisms that cause bacillary dysentery in the Kushtia area would warn the public to be more health conscious, and physicians would administer medications cautiously. The gradual growth of MDR pathogenic microorganisms needs immediate attention, and the discovery of effective medications must take precedence.

Mixed flow pumps applications have been exploited in a large number of diversified fields of engineering. They find applications as an important component in waste water treatment systems, power stations, irrigation systems etc. User requirements make these pumps to work very close to the functioning requirements and therefore under these conditions the vibrations are bound to occur in different moving components of the pump. It would be difficult to analyse the pump vibrations, considering the pump as a single system. Analysing vibrations in different moving components of the pump will not only be easier but also will aid in reducing the vibrations at the microscopic level. As a subject of the present paper, the mixed flow pump impeller blade has been designed using sparingly used yet accurate mean stream line theory. Modal analysis of the pump blade has been carried out at different modes of frequency. Total deformation for different modes of frequencies has also been determined. Stainless steel has been used as the construction material of the impeller blade.