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An Elementary Recursive Bound for Effective Positivstellensatz and Hilbert’s 17th problem
We prove an elementary recursive bound on the degrees for Hilbert’s 17th problem. More precisely we express a nonnegative polynomial
as a sum of squares of rational functions, and we obtain as degree estimates for the numerators and denominators the following tower of
five exponentials
eBook
Toward a general theory of motivation: Problems, challenges, opportunities, and the big picture
Motivation theories have tended to focus on specific motivations, leaving open the intellectually and scientifically challenging problem of how to construct a general theory of motivation. The requirements for such a theory are presented here. The primacy of motivation emphasizes that cognition, emotion, agency, and other psychological processes exist to serve motivation. Both state (impulses) and trait (basic drives) forms of motivation must be explained, and their relationship must be illuminated. Not all motivations are the same, and indeed it is necessary to explain how motivation evolved from the simple desires of simple animals into the complex, multifaceted forms of human motivation. Motivation responds to the local environment but may also adapt to it, such as when desires increase after satiation or diminish when satisfaction is chronically unavailable. Addiction may be a special case of motivation—but perhaps it is much less special or different than prevailing cultural stereotypes suggest. The relationship between liking and wanting, and the self-regulatory management of motivational conflict, also require explanation by an integrative theory.
Journal Article
cell-cell adhesion molecule E-cadherin
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As founder member of the cadherin superfamily, it has been extensively investigated. We summarize the structure and regulation of the E-cadherin gene and transcript. Models for E-cadherin-catenin complexes and cell junctions are presented. The structure of the E-cadherin protein is discussed in view of the diverse functions of this remarkable protein. Homophilic and heterophilic adhesion are compared, including the role of E-cadherin as a receptor for pathogens. The complex post-translational processing of E-cadherin is reviewed, as well as the many signaling activities. The role of E-cadherin in embryonic development and morphogenesis is discussed for several animal models. Finally, we review the multiple mechanisms that disrupt E-cadherin function in cancer: inactivating somatic and germline mutations, epigenetic silencing by DNA methylation and epithelial to mesenchymal transition-inducing transcription factors, and dysregulated protein processing.
Journal Article
Handbook of self-regulation : research, theory, and applications
From leading authorities, this significantly revised and expanded handbook is a highly regarded reference in a rapidly growing field. It thoroughly examines the conscious and unconscious processes by which people manage their behavior and emotions, control impulses, and strive toward desired goals. Chapters explore such vital issues as why certain individuals have better self-control than others; how self-regulation shapes, and is shaped by, social relationships; underlying brain mechanisms and developmental pathways; and which interventions can improve people's self-control. The volume also addresses self-regulatory failures and their consequences, with chapters on attention-deficit/hyperactivity disorder, criminality, addictions, and money management challenges. As a special bonus, purchasers of the third edition can download a supplemental e-book featuring two notable, highly cited chapters from the second edition.
Book
Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome
Abstract
Background
Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown.
Objectives
To study the prognostic value of measures of SIRS in horses and identify the best model of severe SIRS to predict outcome.
Animals
A total of 479 consecutive adult horse emergency admissions to a private primary referral practice.
Methods
Prospective observational study. All adult horses admitted for emergency treatment over the study period were included. Multivariate logistic regression and stepwise model selection were used.
Results
Each of the 4 SIRS criteria was associated with outcome in this population. Thirty-one percent of emergency cases had 2 or more abnormal SIRS criteria on admission and were defined as SIRS cases. SIRS was associated with increased odds of death (odds ratio [OR] = 8.22; 95% CI, 4.61–15.18; P < .001), an effect mainly found for acute gastrointestinal cases. SIRS cases were assigned a SIRS score of 2, 3, or 4, according to the number of abnormal SIRS criteria fulfilled on admission, and SIRS3 and SIRS4 cases had increased odds of death compared to SIRS2 cases (OR = 4.45; 95% CI, 1.78–11.15; P = .002). A model of severe SIRS including the SIRS score, blood lactate concentration, and color of the mucous membranes best predicted outcome in this population of horses.
Conclusions and Clinical Importance
Systemic inflammatory response syndrome is associated with an increased risk of death in adult horses presenting with acute gastrointestinal illnesses. The model of severe SIRS proposed in this study could be used to assess the status and prognosis of adult equine emergency admissions.
Journal Article
The Need to Belong: a Deep Dive into the Origins, Implications, and Future of a Foundational Construct
The need to belong in human motivation is relevant for all academic disciplines that study human behavior, with immense importance to educational psychology. The presence of belonging, specifically school belonging, has powerful long- and short-term implications for students’ positive psychological and academic outcomes. This article presents a brief review of belonging research with specific relevance to educational psychology. Following this is an interview with Emeritus Professors Roy Baumeister and Mark Leary, foundational pioneers in belonging research which reflects upon their influential 1995 paper, “The need to belong: Desire for interpersonal attachments as a fundamental human motivation,” to explore the value and relevance of belonging for understanding human behavior and promoting well-being.
Journal Article