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"Royer, Philippe"
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Carbon capture and storage : technologies, policies, economics, and implementation strategies
This book focuses on issues related to a suite of technologies known as \"Carbon Capture and Storage (CCS),\" which can be used to capture and store underground large amounts of industrial CO2 emissions. It addresses how CCS should work, as well as where, why, and how these technologies should be deployed, emphasizing the gaps to be filled in terms of research and development, technology, regulations, economics, and public acceptance.
Book
Stereotactic radiotherapy on brain metastases with recent hemorrhagic signal: STEREO-HBM, a two-step phase 2 trial
Background
Brain metastases often occur in cancer evolution. They are not only responsible for death but also for disorders affecting the quality of life and the cognitive functions.
Management of brain metastases usually consists in multi-modality treatments, including neurosurgery, whole brain radiotherapy (WBRT), and more recently radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT), systemic treatment (chemotherapy or targeted therapy), combined or not with corticosteroids. Almost 20% of brain metastases can present recent (within 15 days) bleeding signs on neuro-imagery. In these conditions, WBRT is the usual treatment. Yet, patients may benefit from a more aggressive strategy with SRT or FSRT. However, these options were suspected to possibly major the risk of brain haemorrhage, although no scientifically proven. Radiation oncologists therefore usually remain reluctant to deliver SRS/FSRT for bleeding brain metastases.
It is therefore challenging to establish a standard of care for the treatment of bleeding brain metastases.
We propose a phase II trial to simultaneously assess safety and efficacy of FSRT to manage brain metastases with hemorrhagic signal.
Methods
The STEREO-HBM study is a multicenter two-step non-randomised phase II trial addressing patients with at least one bleeding brain metastasis out of a maximum of 3 brain metastases. Each brain metastasis will be treated with 30 Gy in 3 fractions for 1 week.
The main endpoint is based on both safety and efficacy endpoints as proposed by Bryant and Day’s design. Safety endpoint is defined as the rate of bleeding complications 4 months post-FSRT while efficacy endpoint is defined as the 6-month local control rate. Multi-modal MRI will be used to assess intra-tumoral hemorrhagic events before and after treatment. Patients’ quality of life will also be assessed.
Discussion
Management of bleeding brain metastases is still debated and poorly explored in clinical trials. There is sparse and weak data on the signification of pretreatment intra-tumour haemorrhagic signs or on the risk of brain bleeding complications after FSRT.
We expect this first prospective phase 2 trial in this particular setting will allow to clarify the place of FSRT to optimally manage bleeding brain metastases.
Trial registration
NCT 03696680
, registered October, 4, 2018.
Protocol version
Version 2.1 dated from 2018/11/09.
Journal Article
Target volume delineation for radiotherapy of meningiomas: an ANOCEF consensus guideline
Purpose
Radiotherapy is, with surgery, one of the main therapeutic treatment strategies for meningiomas. No prospective study has defined a consensus for the delineation of target volumes for meningioma radiotherapy. Therefore, target volume definition is mainly based on information from retrospective studies that include heterogeneous patient populations. The aim is to describe delineation guidelines for meningioma radiotherapy as an adjuvant or definitive treatment with intensity-modulated radiation therapy and stereotactic radiation therapy techniques. This guideline is based on a consensus endorsed by a multidisciplinary group of brain tumor experts, members of the Association of French-speaking Neuro-oncologists (ANOCEF).
Materials and methods
A 3-step procedure was used. First, the steering group carried out a comprehensive review to identify divergent issues on meningiomas target volume delineation. Second, an 84-item web-questionnaire has been developed to precisely define meningioma target volume delineation in the most common clinical situations. Third, experts members of the ANOCEF were requested to answer. The first two rounds were completed online. A third round was carried out by videoconference to allow experts to debate and discuss the remaining uncertain questions. All questions remained in a consensus.
Results
Limits of the target volume were defined using visible landmarks on computed tomography and magnetic resonance imaging, considering the pathways of tumor extension. The purpose was to develop clear and precise recommendations on meningiomas target volumes.
Conclusion
New recommendations for meningiomas delineation based on simple anatomic boundaries are proposed by the ANOCEF. Improvement in uniformity in target volume definition is expected.
Journal Article
Intense Particulate Pollution Events Observed with Lidar over the Paris Megalopolis
The great particulate pollution event that affected the Paris Megalopolis in March 2014 was due to long-range transport from the northern-northeastern Europe. Although this phenomenon has appeared as exceptional in the media, this is not an exception and similar events have already been observed by lidar measurements. Here we will briefly describe and illustrate the origin of this intense pollution obviously harmful to health.
Journal Article
Aerosol/Cloud Measurements Using Coherent Wind Doppler Lidars
The accurate localization and characterization of aerosol and cloud layers is crucial for climate studies (aerosol indirect effect), meteorology (Planetary Boundary Layer PBL height), site monitoring (industrial emissions, mining,…) and natural hazards (thunderstorms, volcanic eruptions). LEOSPHERE has recently developed aerosol/cloud detection and characterization on WINDCUBE long range Coherent Wind Doppler Lidars (CWDL). These new features combine wind and backscatter intensity informations (Carrier-to-Noise Ratio CNR) in order to detect (aerosol/cloud base and top, PBL height) and to characterize atmospheric structures (attenuated backscatter, depolarization ratio). For each aerosol/cloud functionality the method is described, limitations are discussed and examples are given to illustrate the performances.
Journal Article
Simulation of Doppler Lidar Measurement Range and Data Availability
The measurement range of a coherent wind Doppler lidar (CWDL) along a laser beam is the maximum distance from the lidar where wind speed data are accurately retrieved. It means that, at this distance, a sufficient number of emitted laser photons are backscattered and received by the lidar. Understanding of the propagation of the laser through the atmosphere, and particularly the backscattering and extinction processes from aerosols, is therefore important to estimate the metrological performances of a CWDL instrument. The range is directly related to specific instrument characteristics and atmospheric content, such as the aerosols type, size, and density distributions. Associated with the measurement range is the notion of data availability, which can be defined, at a given range and over a time period, as the percentage number of data retrieved correctly by the CWDL over the total number of measurement attempts.
This paper proposes a new approach to predict the CWDL data availability and range of measurement using both instrumental simulation and atmospheric observations of aerosol optical properties from weather stations and simulations. This method is applied in several CWDL measurement campaigns during which estimated data availabilities and ranges are compared with the observations. It is shown that it is fairly possible to anticipate the data availability and the range coverage of CWDL technology at any site of interest where atmospheric data are available. The method also offers an additional way to diagnose the operation of the instrument and will help in the design of future instruments.
Journal Article
Supplementing honey bee (Hymenoptera: Apidae) colonies with pollen increases their pollinating activity on nectariferous crops with anthers isolated from stigmas
The western honey bee (Apis mellifera L.) is the most globally used managed pollinator species, but it can have limited pollinating activity on nectariferous crops displaying anthers isolated from stigmas, i.e., when anthers are spatially or temporally separated from stigma within or between flowers. We supplemented honey bee colonies with pollen in the combs or in paste form laid on top of the hive frames to test if these treatments could reduce their pollen foraging and increase their pollinating activity in a monoecious and nectariferous cultivar of cantaloupe melon (Cucumis melo L.), in comparison with control colonies not supplemented. We recorded the pollen forager density per flower, the number of pollen grains deposited per stigma and their resulting fruit set, seed set and fruit mass, before and after the colony pollen supplementations. The number of pollen grains deposited by honey bees on stigmas increased gradually after pollen supplementation in the combs. But pollen foraging decreased only moderately, and no effect could be observed on any yield component except the seed set. On the other hand, there was no effect of the pollen paste laid on top of the frames either on stigmatic pollen loads, on colony pollen foraging or on any yield component. Supplementing honey bee colonies with pollen in the combs can therefore be an effective means for increasing their pollinating activity in nectariferous crops displaying anthers isolated from stigmas, e.g., Amaryllidaceae, Apiaceae, Cucurbitaceae, avocado, all hybrid seed productions. The context for the potential use of pollen substitutes is discussed.
Journal Article
Eyjafjallajökull ash concentrations derived from both lidar and modeling
Following the eruption of the Icelandic volcano Eyjafjallajökull on the 14 April 2010, ground‐based N2‐Raman lidar (GBL) measurements were used to trace the temporal evolution of the ash plume from 16 to 20 April 2010 above the southwestern suburb of Paris. The nighttime overpass of the Cloud‐Aerosol LIdar with Orthogonal Polarization onboard Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation satellite (CALIPSO/CALIOP) on 17 April 2010 was an opportunity to complement GBL observations. The plume shape retrieved from GBL has been used to assess the size range of the particles size. The lidar‐derived aerosol mass concentrations (PM) have been compared with model‐derived PM concentrations held in the Eulerian model Polair3D transport model, driven by a source term inferred from the SEVIRI sensor onboard Meteosat satellite. The consistency between model and ground‐based wind lidar and CALIOP observations has been checked. The spatial and temporal structures of the ash plume as estimated by each instrument and by the Polair3D simulations are in agreement. The ash plume was associated with a mean aerosol optical thickness of 0.1 ± 0.06 and 0.055 ± 0.053 for GBL (355 nm) and CALIOP (532 nm), respectively. Such values correspond to ash mass concentrations of ∼400 ± 160 and ∼720 ± 670 μg m−3, respectively, within the ash plume, which was lower than 0.5 km in width. The relative uncertainty is ∼75% and mainly due to the assessment of the specific cross‐section assuming an aerosol density of 2.6 g cm−3. The simulated ash plume is smoother leading to integrated mass of the same order of magnitude (between 50 and 250 mg m−2).
Key Points
Assessment of the ash plume mass concentration
Comparison between lidar and modeling
Retrieval of the optical properties of the ash plume
Journal Article
Experimental results on electron beam combination and bunch frequency multiplication
The aim of the CLIC Test Facility CTF3 at CERN is to demonstrate the feasibility of the key points of the two-beam acceleration based compact linear collider study. In particular, it addresses the efficient generation of a drive beam with the appropriate time structure of the electron bunches in order to produce high power rf pulses at a frequency of 30 GHz. This time structure requires a high bunch repetition frequency. It is obtained by successive injections of bunch trains into an isochronous ring using transversely deflecting rf structures. The major goal of the now completed first phase of the CTF3 was to achieve the bunch train combination at low charge. In this paper, we give a description of the project and summarize the experimental results, with a focus on the successful bunch frequency multiplication for various factors up to 5.
Journal Article