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A bstract We examine holographic complexity in the doubly holographic model introduced in [1, 2] to study quantum extremal islands. We focus on the holographic complexity=volume (CV) proposal for boundary subregions in the island phase. Exploiting the Fefferman-Graham expansion of the metric and other geometric quantities near the brane, we derive the leading contributions to the complexity and interpret these in terms of the generalized volume of the island derived from the induced higher-curvature gravity action on the brane. Motivated by these results, we propose a generalization of the CV proposal for higher curvature theories of gravity. Further, we provide two consistency checks of our proposal by studying Gauss-Bonnet gravity and f (ℛ) gravity in the bulk.

A bstract Recently, new holographic models of black hole evaporation have given fresh insights into the information paradox [ 1 – 3 ]. In these models, the black hole evaporates into an auxiliary bath space after a quantum quench, wherein the holographic theory and the bath are joined. One particularly exciting development is the appearance of ‘ER=EPR’-like wormholes in the (doubly) holographic model of [ 3 ]. At late times, the entanglement wedge of the bath includes the interior of the black hole. In this paper, we employ both numerical and analytic methods to study how information about the black hole interior is encoded in the Hawking radiation. In particular, we systematically excise intervals from the bath from the system and study the corresponding Page transition. Repeating this process ad infinitum, we end up with a fractal structure on which the black hole interior is encoded, implementing the überholography protocol of [ 4 ].

A bstract We study the doubly holographic model of [1] in the situation where a black hole in two-dimensional JT gravity theory is coupled to an auxiliary bath system at arbitrary finite temperature. Depending on the initial temperature of the black hole relative to the bath temperature, the black hole can lose mass by emitting Hawking radiation, stay in equilibrium with the bath or gain mass by absorbing thermal radiation from the bath. In all of these scenarios, a unitary Page curve is obtained by applying the usual prescription for holographic entanglement entropy and identifying the quantum extremal surface for the generalized entropy, using both analytical and numeric calculations. As the application of the entanglement wedge reconstruction, we further investigate the reconstruction of the black hole interior from a subsystem containing the Hawking radiation. We examine the roles of the Hawking radiation and also the purification of the thermal bath in this reconstruction.

A bstract We study the complexity of Gaussian mixed states in a free scalar field theory using the ‘purification complexity’. The latter is defined as the lowest value of the circuit complexity, optimized over all possible purifications of a given mixed state. We argue that the optimal purifications only contain the essential number of ancillary degrees of freedom necessary in order to purify the mixed state. We also introduce the concept of ‘mode-by- mode purifications’ where each mode in the mixed state is purified separately and examine the extent to which such purifications are optimal. We explore the purification complexity for thermal states of a free scalar QFT in any number of dimensions, and for subregions of the vacuum state in two dimensions. We compare our results to those found using the various holographic proposals for the complexity of subregions. We find a number of qualitative similarities between the two in terms of the structure of divergences and the presence of a volume law. We also examine the ‘mutual complexity’ in the various cases studied in this paper.

A bstract We examine the circuit complexity of coherent states in a free scalar field theory, applying Nielsen’s geometric approach as in [ 1 ]. The complexity of the coherent states have the same UV divergences as the vacuum state complexity and so we consider the finite increase of the complexity of these states over the vacuum state. One observation is that generally, the optimal circuits introduce entanglement between the normal modes at intermediate stages even though our reference state and target states are not entangled in this basis. We also compare our results from Nielsen’s approach with those found using the Fubini-Study method of [ 2 ]. For general coherent states, we find that the complexities, as well as the optimal circuits, derived from these two approaches, are different.

A bstract We generalize the Fubini-Study method for pure-state complexity to generic quantum states by taking Bures metric or quantum Fisher information metric (QFIM) on the space of density matrices as the complexity measure. Due to Uhlmann’s theorem, we show that the mixed-state complexity exactly equals the purification complexity measured by the Fubini-Study metric for purified states but without explicitly applying any purification. We also find the purification complexity is non-increasing under any trace-preserving quantum operations. We also study the mixed Gaussian states as an example to explicitly illustrate our conclusions for purification complexity.

A bstract We expand on our results in [ 1 ] to present a broad new class of gravitational observables in asymptotically Anti-de Sitter space living on general codimension-zero regions of the bulk spacetime. By taking distinct limits, these observables can reduce to well-studied holographic complexity proposals, e.g., the volume of the maximal slice and the action or spacetime volume of the Wheeler-DeWitt patch. As with the codimension-one family found in [ 1 ], these new observables display two key universal features for the thermofield double state: they grow linearly in time at late times and reproduce the switchback effect. Hence we argue that any member of this new class of observables is an equally viable candidate as a gravitational dual of complexity. Moreover, using the Peierls construction, we show that variations of the codimension-zero and codimension-one observables are encoded in the gravitational symplectic form on the semi-classical phase-space, which can then be mapped to the CFT.

A bstract We investigate how the complexity=anything observables proposed by [1, 2] can be used to investigate the interior geometry of AdS black holes. In particular, we illustrate how the flexibility of the complexity=anything approach allows us to systematically probe the geometric properties of black hole singularities. We contrast our results for the AdS Schwarzschild and AdS Reissner-Nordström geometries, i.e., for uncharged and charged black holes, respectively. In the latter case, the holographic complexity observables can only probe the interior up to the inner horizon.

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%, whereas that of patients with distant metastasis is less than 5%. Surgical resection is the best option for early-stage gastric cancer, while chemotherapy is mainly used in the middle and advanced stages of this disease, despite the frequently reported treatment failure due to chemotherapy resistance. Therefore, there is an unmet medical need for identifying new biomarkers for the early diagnosis and proper management of patients, to achieve the best response to treatment. Long non-coding RNAs (lncRNAs) in body fluids have attracted widespread attention as biomarkers for early screening, diagnosis, treatment, prognosis, and responses to drugs due to the high specificity and sensitivity. In the present review, we focus on the clinical potential of lncRNAs as biomarkers in liquid biopsies in the diagnosis and prognosis of gastric cancer. We also comprehensively discuss the roles of lncRNAs and their molecular mechanisms in gastric cancer chemoresistance as well as their potential as therapeutic targets for gastric cancer precision medicine.

A bstract In this paper, we investigate gluing together two Anti-de Sitter (AdS) geometries along a timelike brane, which corresponds to coupling two brane field theories (BFTs) through gravitational interactions in the dual holographic perspective. By exploring the general conditions for this gluing process, we show that the energy stress tensors of the BFTs backreact on the dynamical metric in a manner reminiscent of the TTbar deformation. In particular, we present explicit solutions for the three-dimensional case with chiral excitations and further construct perturbative solutions with non-chiral excitations.