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When he was 10 years old, Shadle was given a precious book of music that his great-great-great-grandmother brought with her on the Trail of Tears (the forced removal of Native Americans to Oklahoma from their southeastern homelands beginning in the 1830s). Raven took piano lessons as an adolescent, teaching himself guitar and composition when he was 12. The work intends to bridge the gap between method books and more challenging classical repertoire. According to Hwaen, each movement depicts a different animal and combines a study in color and emotion as an exploration of technique.

Late-onset Alzheimer’s disease (AD) is an age-related disease. The geroscience concept dictates that interventions that slow aging should also slow age-related diseases. This concept was tested in C57BL/6 mice expressing a CRISPr engineered IGF1R variant R407H shown to be enriched in centenarians. A total of 14 females, 25 to 28 months of age, carrying the R407H variant or wild type, were given intravenous injections of AAV9-PHP.eb serotype concoctions at 10^12 vg per dose, containing either a mCherry-sham construct or Aβ42 and pTau constructs associated with neuropathology of AD. Mice were followed for 11 weeks and then tested for cognition. Following euthanasia, brains were collected, and hippocampal tissues processed for RNA sequencing (Novogene, Sacramento). The mice with the IGF1r variant, and infected with AAV Aβ42 and pTau, showed significantly better performance in a spatial navigation learning task compared to wild type cohorts. RNA sequencing analysis in the same cohorts using DES Seq2 showed a significant downregulation of inflammatory cytokines and chemokines including Ccl21b (log2 fold change = -2.3, adjusted p-value < 0.05). These preliminary observations suggest the potential of further studying naturally occurring rare variants such as IGF1r R407H as a way to help slow or prevent AD, in line with the geroscience concept.

Suzanne Greer, a Minnesota State Certified Teacher of Music, holds BM and MM degrees in piano performance and maintains a successful private studio of both traditional and Suzuki piano students. [...]getting students off the bench to try the steps of a baroque dance help them understand rhythm and tempo. Every connection makes the music come alive and just might increase desire, student motivation and practice time! -Sue Ruby, NCTM, holds BM and MM degrees in piano pedagogy and is on the faculty at the MacPhail Center for Music in Minneapolis, Minnesota, where she maintains a large studio teaching students of all ages and abilities.

Gandera, the son of a renowned musician, was a principal drummer of the famous Gunung Sari gamelan in the village of Peliatan (and a superb dancer as well!). Political differences had made it impossible for members of the gamelan to play together and even prevented the village from organizing any temple ceremonies.

The process of aging is defined by the breakdown of critical maintenance pathways leading to an accumulation of damage and its associated phenotypes. Aging affects many systems and is considered the greatest risk factor for a number of diseases. Therefore, interventions aimed at establishing resilience to aging should delay or prevent the onset of age-related diseases. Recent studies have shown a three-drug cocktail consisting of rapamycin, acarbose, and phenylbutyrate delayed the onset of physical, cognitive, and biological aging phenotypes in old mice. To test the ability of this drug cocktail to impact Alzheimer's disease (AD), an adeno-associated-viral vector model of AD was created. Mice were fed the drug cocktail 2 months prior to injection and allowed 3 months for phenotypic development. Cognitive phenotypes were evaluated through a spatial navigation learning task. To quantify neuropathology, immunohistochemistry was performed for AD proteins and pathways of aging. Results suggested the drug cocktail was able to increase resilience to cognitive impairment, inflammation, and AD protein aggregation while enhancing autophagy and synaptic integrity, preferentially in female cohorts. In conclusion, female mice were more susceptible to the development of early-stage AD neuropathology and learning impairment, and more responsive to treatment with the drug cocktail in comparison to male mice. Translationally, a model of AD where females are more susceptible would have greater value as women have a greater burden and incidence of disease compared to men. These findings validate past results and provide the rationale for further investigations into enhancing resilience to early-stage AD by enhancing resilience to aging.Competing Interest StatementThe authors have declared no competing interest.

Although conventional wisdom maintains that vegetation can reduce the concentration of airborne particulate pollutants, few studies have systematically tested this assumption or focused on particulates of diameter ≤ 2.5 μm (PM2.5). I developed novel methods to isolate the effects of leaf surface roughness, total surface area, and canopy density on dry deposition and re-suspension. I quantified leaf roughness using a non-contact profilometer, surface effects by directly counting fluorescent tracers on leaf surfaces, and decreases in airborne concentration by comparing the decay kinetics of particulates in a wind tunnel containing different leaf types. PM2.5 deposition velocities were calculated for Platanus x acerifolia, Pyrus calleryana, and Picea abies, which bracket extreme surface topographies. There were clear surface roughness effects on deposition, but plant canopies did not significantly reduce airborne concentrations. Platanus trichomes were particularly good for particle capture, however these trichomes were also easily abraded and particles re-suspended. Vegetation inserted into the wind tunnel at both natural and unnaturally high foliage densities did not decrease airborne PM2.5 below a regulatory level regardless of species. Deposition velocities for both high-density and low-density Pyrus and Picea were smaller than to the wind tunnel interior surface. Sandpapers of similar surface roughness values did not retain particles as well as leaf surfaces. Deposition velocities to commercial filters were significant. In a methods comparison testing Pyrus calleryana, Tilia tomentosa, and Tilia cordata, the method relying on airborne concentrations resulted in more consistent estimates of deposition velocity than the surface counting method. Determining the surface area variable in the flux term was the biggest limitation of the air-dependent method. Raw deposition rate may be a better indicator of total particles removed by the test canopy. Bridging the gap between the micron particle vegetative canopy scale is challenging but can be addressed by employing both surface and air stream counting methods simultaneously. Though fine-scale differences in deposition were found on surfaces, leaf area and density comparisons did not favor the use of trees for PM2.5 control. Attenuation at the source is ideally the best alternative.

Sekar muncerat (Samban village) (5:47) -- Tujang biru (Mas village) (1:28) -- Gelang kangin (Peliatan village (Banjar Tengah)) (2:59) -- Kutri (Sayan village) (2:59) -- Godeg miring (Mas village) (3:41) -- Tabuh telu liko (Mas village) (3:46) -- Lambatan galang kangin (Ketewel village) (12:52) -- Gambangan (Sayan village) (3:35) -- Sayambara (Padangtegal village) (9:23) -- Tabuh telu gegineman (Sayan village) (6:08) -- Lagu no. 3 (Jineng Dalem Selatan village) (5:09) -- Gambangan (Ketewel village) (4:18) -- Hujan mas (Ketewel village) (11:00).

This research was conducted to investigate perceptions of self-esteem and the behavior of female science students in mixed gender cooperative learning groups. The research methodology used was qualitative in nature, which included a variety of data collection methods, including participant observation, student journals, interviews, video tapes of group interactions, cooperating teachers' journals, individual surveys, group surveys, and daily field notes. The data was analyzed by means of the constant comparative method. The analysis resulted in the following two hypotheses: (1) When male science students are allowed to dominate group activities female self-esteem and group interactions are affected negatively. (2) Female science students tend to be less openly critical of other students in their groups than male science students to maintain group relationships.