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This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects. This report provides up-to-date usable information to: (1) improve the knowledge and skills of allergists, so as to ultimately improve the overall quality of patient care; (2) to increase interest in this area; and (3) to present a unique contribution to the field of upper inflammatory disease.

A plasma-chemical method for the modification of silicon carbide particles is presented, which makes it possible to obtain particles with a controlled surface morphology. The variable parameter of particle processing was the ratio of the fraction of plasma-forming (Ar) and additional (H) gases. It was shown that at Ar/H = 100/0, the formation of a carbon shell is observed; at Ar/H ratios of 91/9 and 84/16, the particles are characterized by a carbon shell decorated with silicon nanoparticles or nanowires, respectively. The modified particles were analyzed using scanning electron microscopy and Raman spectroscopy.

The future of agriculture is digital. In the context of accelerated digitalization of the agricultural sector of the economy, it is important to assess the effectiveness of certain tools of digitalization in the production and management of agricultural enterprises. The purpose of the article is to assess the economic efficiency of the introduction of certain tools for digitalization of management in agricultural enterprises based on the analysis of investment projects depending on the size of the land bank of agricultural producers and their investment opportunities. Results of the research. The forecast indicators of the value of money and discounting coefficients necessary for the construction of a strategic horizon of proposals for the implementation of individual investment projects of digitization tools have been calculated. An analysis of cash flow indicators in the implementation of individual investment projects for the purchase of digitization tools. The main economic indicators of efficiency of realization of investment projects at the land bank of the agricultural enterprise in 500 and 5000 hectares have been defined. The expediency of practical introduction of digitization tools in agricultural enterprises has been substantiated. Calculations of efficiency indicators of acquisition of tools of digitalization of agricultural production have been conducted. This allows both large and small in size land bank agricultural enterprises to determine the feasibility of investing in investment projects of varying complexity. Keywords: digitalization tools, agricultural enterprises, investment project, efficiency, land bank, financial resources. JEL Classification Q160 Formulas: 0; fig.: 0; tabl.: 4; bibl.: 11.

The instability of the domestic economy and the influence of external factors lead to the deviation of the basic macroeconomic indicators from the normative equilibrium values. This requires the development of a qualitatively new integrated approach to the analysis of the main macroeconomic indicators of the development of the economy sectors in order to identify the effective institutional and financial foundations for stimulating economic progress of our state. The purpose of the work is to study the theoretical positions of the financial and real sectors of the economy and conduct an econometric analysis of the indicators of their development. Results. Theoretical positions about the place of the real and financial sectors of the economy in the general economic system of the state has been systematized in the article. The main indicators (KPIs — key performance indicators) of the studied sectors of the economy has been revealed. The econometric analysis of the main indicators of the development of the economy sectors has been based on real (actual) values corrected for inflation and has been presented in the classical theoretical Hix-Hansen equilibrium model on commodity and money markets (IS-LM). The data of the National Bank of Ukraine on the dynamics of the monetary base (B) and monetary aggregates (M0 — M3), and the State Statistics Service of Ukraine on GDP (Y) and inflation (СРІ) has been used in the research. The econometric analysis has showed a significant correlation between the nominal and real GDP, money supply and money base indicators, which are almost synchronized during 2001—2017. The presence of strong interdependence between the real values of these indicators has been confirmed by very high correlation values, which are ranged from 0.94 to 0.99. Almost functional dependence of the money supply on the monetary base has been explained by the availability of the existing mechanism of monetary multiplication, and the money market multiplier tends to increase. The high statistical dependence between the real NBU discount rate and the weighted average rate on all instruments has been revealed. It proved the effectiveness of the main instrument for implementing the discrete monetary policy of macroeconomic regulation. The negative significance of the correlation coefficients between the interest rates and the quantitative indicators of the real and financial sectors of the economy has shown that the traditional theoretical compromise in choosing the main problems to be solved in the economy to ensure macroeconomic stability is also typical for Ukraine. The application of the «expensive money» policy to combat high inflation negatively affects the real money supply, but taking into account the very high dependence between it and GDP, slows down the growth of the real sector of the economy, and vice versa. The obtained two-factor regression equation with very high reliability has explained by the retrospective changes in the real money supply. The most important factor for it is real GDP. This confirms the strong interconnection between the real and financial sectors of the economy in the process of developing the economic system. Quantitative indicators of development of both sectors are under the influence of long-term trends. They have their own nature and often depend on trends in the development of the world economy and finance as well as internal problems that are often predictable. Conclusions. The results has been obtained suggest that the synchronous long-term dynamics of real GDP, money supply and money base, as well as the statistical interdependence between them, firstly, signal that in Ukraine the rules of a market economy have already been formed and can be applied effectively in such conditions of the methods and tools of macroeconomic regulation, and secondly, processes occurring in one of the specified sectors of the economy will necessarily reflect on another. Therefore, solving macroeconomic problems requires a balanced and integrated approach taking into account the nature and strength of the interdependence between different processes and phenomena.

According to modern statistics and analytical reviews, targeted computer attacks (cyber attacks) are becoming more and more numerous. Attackers began to use non-standard schemes for implementing attacks, using employees of organizations as intermediaries, which reduces the efficiency of detecting violations. At the same time, the targets of attackers are increasingly critical information infrastructure (CII) objects. The number of cyberattacks on the critical infrastructure of the Russian Federation increased by 150%. Successful attacks on CII are associated with a lack of software updates for industrial equipment, personnel errors, incorrect configuration of protection tools and can potentially lead to disasters. Prediction of computer attacks on CII based on a comprehensive analysis of the characteristics of incidents and system users can significantly increase the efficiency of incident detection, since it is obvious that technical and anthropogenic characteristics in this case should be taken into account together. It is difficult to classify computer incidents due to the volume and heterogeneity of the data about them. The paper proposes approaches that provide for the initial systematization of system log data and user characteristics, an assessment of their informativeness. This will reduce the complexity of further data processing and increase the performance of the computer attack forecasting system by excluding some uninformative data from a single secure storage. The second important task is to create test systems based on available platforms for analyzing and detecting computer incidents in order to train future information security specialists in big data analysis technologies.

The article examines the methodology of assessing bank’s financial stability. It is researched scientific evolution of financial stability nature definition, discerning endogenous and exogenous approaches. It is proved that financial stability simultaneously feels effect from endogenous and exogenous factors and it should be taking into consideration while managing financial stability of a bank, as well as assessing its level. It is grounded a set of requirements while constructing methodological approach for assessing bank’s financial stability that are as follows: it is necessary to form a set of indicators that would allow to characterize the bank’s activity in complex; it is important to consider the dynamic nature of financial stability; it is significant to take into account how any indicator effects on the bank’s financial stability. It is proved taxonomy method as an effective technology of processing quantitative indicators of bank’s financial stability. We propose to normalize values of indicators by the Euclidean distance tool in order to figure out their deviation from the determined standard values. It is proposed to use a set of indicators for assessing the bank’s financial stability, that are grouped as follows: 1) the quality of capitalization; 2) the level of liquidity; 3) quality of assets; 4) risk-validity of business activity; 5) currency risk;6) credit risk; 7) profitability; 8) operational risk; 9) interest rate risk; 10) factors of the macroeconomic environment. In general, it is proposed to use thirty-eight indicators which are presented by point and dynamic ones. Practical approbation of the proposed methodological approach is carried out on the example of systemically important banks of Ukraine. The purpose of the article is to improve methodology of assessing bank’s financial stability using taxonomy approach. The proposed method, in contrast to the existing ones, provides: 1) flow method construction of a set of indicators; 2) implementation of point and dynamic indicators; indicators-stimulators / destimulators and of a mixed type; 3) indicative consideration of macroeconomic environment factors. The application of such an approach allows to comprehensively determine the level of bank’s financial stability and to quantify the impact of the macroeconomic environment on it. Keywords: bank’s financial stability, taxonomy method, dynamic indicator, integrated index of bank’s financial stability, normalization of indicators, indicator-stimulator, indicator-destimulator. JEL Classification C13, C81, D53, G21, G23 Formulas: 6; fig.: 1; tabl.: 2; bibl.: 32.

The scientific article is devoted to the development of a methodology for assessing the financial stability of financial corporations using the technology of cascading approach to identify weak areas in their activities and prevent the development of threats to their stable operation. The root causes of their financial instability are selected as the object of financial corporations’ financial stability assessment, and a chain of causal relationships is considered that turn the preconditions into real threats to financial stability or even signs of the corporation’s financial fragility. At the same time, the source of prerequisites for the financial stability of financial corporations in the state and depth of imbalances, which are formed both in the internal and external environment of their operation. It is proved that the tools for assessing internal imbalances in the activities of financial corporations should not be limited to financial imbalances, as their root causes can be concentrated in the organizational, managerial, institutional, conceptual component, in the field of personnel, information, technical support. Therefore, the structuring of imbalances in the activities of financial corporations is proposed to be carried out according to the theory of economic potentials and to identify the following content areas: opportunities, resources, tools, and abilities, the interaction of which forms the potential of financial corporations to operate. A three-stage method for assessing the financial stability of financial corporations has been developed, using a cascading approach, which involves the consistent diagnosis of internal imbalances in the activities of financial corporations: 1) those that arise within each component (resources, means, and capabilities) and are the area of origin of internal threats to their financial stability; 2) imbalances that arise through inter-component interaction (resources-means; abilities-means; resources-abilities) and are the sphere of manifestations of imbalances; 3) those that arise through interaction with the external environment and maximally show the impact of their condition and depth on the level of financial stability. For each of these areas, a set of indicators has been developed and an algorithm for calculating the integrated index of financial stability of a financial corporation has been constructed. The scientific and methodological approach was tested on the example of systemically important banks of Ukraine during 2017—2020, each of which is currently in a continuum of financial stability, and for most banks, there is a growing trend of quantitative measurement of its level. In general, the paper reveals a comprehensive approach to assessing the financial stability of financial corporations, which allows you to systematize those key positions in which the imbalance increases the likelihood of their financial fragility and financial instability. Keywords: financial corporations, financial stability, internal imbalances, economic potential, valuation, indicators, nonlinear rationing. JEL Classіfіcatіon C13, C81, D53, G21, G23          Formulas: 7; fig.: 0; tabl.: 3; bibl.: 22.

Raising social standards is an essential instrument of social policy by the state. However, the decision to raise the minimum wage rather sharply should consider its impact on fiscal and monetary policy. The article aims to study how government decisions on social standards (in particular minimum wages) can influence monetary policy decisions based on inflation targeting. Results of the research. The method of analysis of indicators and consequences of the introduction of inflation targeting in Ukraine, geographical neighbors and countries with similar economies is described. It is determined that the final effect of changes in social standards on inflation depends on the entire transmission mechanism, which includes several interrelated reactions, and maybe stretched over time, depending on both the speed of transmission of the impulse and the specifics of institutional regulation. It is established that the criterion for a dramatic increase in the minimum wage is a significant upward shift of the minimum wage to the average wage ratio curve. In this case, as we have shown, inflation expectations worsen, which modifies somewhat the behaviour of economic agents and is transferred to current inflation rates in the future. Raising social standards is a good decision of the government in order to maintain household incomes. However, to ensure the neutrality of such a decision for fiscal and monetary policy, it needs to be aligned with its objectives and strategies. Keywords: social standards, monetary policy, inflation targeting, minimum wage, GDP, government. JEL Classification Е 600 Formulas: 0; fig.: 3; tabl.: 1; bibl.: 17.

The integration of companies is crucially important in the ongoing globalization processes. Companies must unify the material assets and optimize property. The integration of the company, incrementally, and competency development is also essential in order to expand the competitiveness of the company’s integrated structure. Identification and management of competencies are especially important for the enterprise structures, which carry out the integration processes. The level of competency development and the types of competencies may or may not be similar. The aim of this research is to specify and develop an organizational competency structure, which groups individual competencies of an organization into various segments based on their similarity. This research is relevant due to the need to systematize and streamline competencies in order to better identify them and develop a set of measures for their monitoring. The theoretical literature analysis allowed us to create a model that characterizes the assumed impact of the competencies on the successful integration of companies. Based on the data, we divided the organizational competencies into five major categories are. An empirical assessment of the impact of the competencies on the market success of the integration of enterprise structures is provided. This research indicates that the success of such integration is substantially determined by the formation and development of the competencies. The authors interviewed top managers of 225 medium and large-sized companies from all over the country were (the questionnaire was created by Rudenko M.N.) The time lag is 5 years. Thereby, the results can be used in the process of regional policy formation.

Hydrodynamic cavitation is an effective means to ensure the intensification of various processes carried out in liquid media.