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Researchers of projects at the sub-Antarctic Prince Edward Islands are increasingly considering geospatial data as an essential component in answering scientific questions. A need exists for high-resolution geospatial data in both multi- and transdisciplinary research to better analyse fine-scale biotic–abiotic interactions of the Islands’ landscape and ecosystems within the context of climate change and the impacts of invasive species. However, much of the geospatial data that currently exist have limitations in spatial coverage and/or resolution, are outdated, or are not readily available. To address these issues, we present an online geospatial database for the Prince Edward Islands (both islands) produced from a high-resolution digital surface model and satellite imagery. This database contains vector files, raster data sets, and maps of topographical and hydrological parameters. It is freely available to download from Figshare – an open access data repository. We encourage the South African polar science community to make use of similar platforms for improved data sharing practices. SIGNIFICANCE : • A topographical and hydrological geospatial database – produced from a 1 m x 1 m digital surface model of the Prince Edward Islands – is provided. • These fine-scale geospatial data allow for a more comprehensive assessment of biotic–abiotic interactions at an island scale. • Also included are locality maps specifying place names and established long-term marine mammal monitoring beaches and coastal zones for improved cross-referencing. • The dataset is downloadable from an open access data repository and intended to promote open science and data sharing practices.

Since the discovery of glacial features on sub-Antarctic Marion Island, the character and extent of a historic glacial period have remained an important research focus for earth science investigations. Previous glacial reconstructions were limited to mostly pre-GPS field observations and pre-digital mapping through a Geographic Information System. With the aid of GPS field mapping, high-resolution satellite imagery and a digital surface model with a 1 × 1 m cell resolution, this paper provides a comprehensive, geo-rectified spatial geodatabase and map of Marion Island's glacial geomorphology. The geodatabase includes an inventory of glacial erosional (e.g. striations) and depositional (e.g. moraines) features compiled from existing records as well as new features mapped from recent field observations. The final map and the geodatabase, which is downloadable as ESRI layer-package files, will aid future field investigations and modelling applications to understand Marion Island's Quaternary landscape evolution and post-glacial ecological succession.

Rock glaciers are lobate or tongue-shaped landforms which consist of rock debris and have either an ice core or an ice-cemented matrix. Characteristics such as the landscape setting, morphology, material and current geomorphological state are universally used to classify rock glaciers. In Antarctica, rock glaciers have only been surveyed on the Antarctic Peninsula, Ellsworth Mountains and in Victoria Land. This paper presents the first data on the identification and description of rock glaciers in the Jutulsessen nunataks, Dronning Maud Land, East Antarctica. The rock glaciers in the Jutulsessen exhibit a variety of morphologies and states. Our data suggests that the rock glaciers in Brugdedalen and Jutuldalen are active, while the features at Vassdalen and Grjotlia are considered inactive, and a feature at Grjotøyra is considered relict. The described rock glaciers do not fit into existing classification systems and appear to be different to alpine, Arctic and Andean rock glaciers. They further present examples that fit both the ‘glaciogenic’ and ‘permafrost’ development theories.

Sub-Antarctic Marion Island's glacial history has acted as a control on abiotic terrestrial processes and the colonization and distribution of biotic species found on the island today. Recent chronological studies have shown an early deglaciation of the island and identified new geomorphological features associated with past ice dynamics. These permit a reassessment of ice extent during and after the island's last local glacial maximum. In this paper, we provide a revised reconstruction of the island's palaeo-ice extent by using a geomorphology-based approach to delineate palaeo-ice margins and demarcate possible glacial basins. The model presented here provides the needed spatial context for future studies on the variations in the distribution of species (e.g. microorganisms and plant species) and abiotic processes and forms (e.g. soil development and periglacial landforms). In addition, it highlights areas that require improved geophysical assessment in order to produce a more complete island-scale reconstruction of former ice extents (e.g. the west coast).

Researchers of projects at the sub-Antarctic Prince Edward Islands are increasingly considering geospatial data as an essential component in answering scientific questions. A need exists for high-resolution geospatial data in both multi- and transdisciplinary research to better analyse fine-scale biotic–abiotic interactions of the Islands’ landscape and ecosystems within the context of climate change and the impacts of invasive species. However, much of the geospatial data that currently exist have limitations in spatial coverage and/or resolution, are outdated, or are not readily available. To address these issues, we present an online geospatial database for the Prince Edward Islands (both islands) produced from a high-resolution digital surface model and satellite imagery. This database contains vector files, raster data sets, and maps of topographical and hydrological parameters. It is freely available to download from Figshare – an open access data repository. We encourage the South African polar science community to make use of similar platforms for improved data sharing practices.Significance: • A topographical and hydrological geospatial database – produced from a 1 m x 1 m digital surface model of the Prince Edward Islands – is provided. • These fine-scale geospatial data allow for a more comprehensive assessment of biotic–abiotic interactions at an island scale. • Also included are locality maps specifying place names and established long-term marine mammal monitoring beaches and coastal zones for improved cross-referencing. • The dataset is downloadable from an open access data repository and intended to promote open science and data sharing practices.

IntroductionThe aim of this study is to rigorously review the efficacy and safety of olanzapine in defined hematology oncology settings including (1) the setting of highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) settings (2) at 5 mg and 10 mg doses, and (3) for response rates for use in the acute, delayed, and overall settings post-MEC and HEC.MethodsOvid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were searched through April 23, 2020. The primary efficacy endpoints were the rate of complete response, in the acute (0–24 h post-chemotherapy), delayed (24–120 h post-chemotherapy), and overall (0–120 h post-chemotherapy) phases. The secondary efficacy endpoints were the rates of no nausea and no emesis, for each phase. Safety endpoints were the rate of no serious adverse events (i.e., no grade 3 or 4 toxicities), as assessed by Common Terminology Criteria for Adverse Events (CTCAE) criteria. The Mantel-Haenszel, random-effects analysis model was used to compute risk ratios and accompanying 95% confidence intervals for each endpoint. For endpoints that statistically favored one arm, absolute risk differences were computed to assess whether there is a 10% or greater difference, used as the threshold for clinical significance by MASCC/ESMO. Fragility indices were also calculated for each statistically significant endpoint, to quantitatively assess the robustness of the summary estimate. A cumulative meta-analysis was conducted for each efficacy meta-analysis with more than 5 studies, also using the Mantel-Haenszel random-effects analysis model.ResultsThree studies reported on olanzapine for the rescue of breakthrough chemotherapy-induced nausea and vomiting (CINV); 22 studies reported on olanzapine in the prophylactic setting. For studies reporting on HEC patients, olanzapine-containing regimens were statistically and clinically superior in seven of nine efficacy endpoints in the prophylaxis setting. When olanzapine is administered at a 10-mg dose, it is statistically and clinically superior to control patients in eight of nine endpoints among adults. Olanzapine may be effective in the MEC setting and when administered at 5-mg doses, but the paucity of data leads to notable uncertainty.ConclusionFurther RCTs are needed in the setting of MEC patients and administration of olanzapine at a lower 5-mg dose, which may be given to reduce the sedative effect of olanzapine at 10 mg.

Given the challenges and costs associated with implementing HIV-1 incidence assay testing, there is great interest in evaluating the use of commercial HIV diagnostic tests for determining recent HIV infection. A diagnostic test with the capability of providing reliable data for the determination of recent HIV infection without substantial modifications to the test protocol would have a significant impact on HIV surveillance. The Abbott ARCHITECT HIV Ag/Ab Combo Assay is an antigen/antibody immunoassay, which meets the criteria as the first screening test in the recommended HIV laboratory diagnostic algorithm for the United States. In this study, we evaluated the performance characteristics of the ARCHITECT HIV Ag/Ab Combo signal-to-cutoff ratio (S/Co) for determining recent infection, including estimation of the mean duration of recent infection (MDRI) and false recent rate (FRR), and selection of recency cutoffs. The MDRI estimates for the S/Co recency cutoff of 400 is within the 4 to 12 months range recommended for HIV incidence assays, and the FRR rate for this cutoff was 1.5%. Additionally, ARCHITECT Combo S/Co values were compared relative to diagnostic test results from two prior prospective HIV-1 diagnostic studies in order to validate the use of the S/Co for both diagnostic and recency determination. Dual-use of the ARCHITECT Combo assay data for diagnostic and incidence purposes would reduce the need for separate HIV incidence testing and allow for monitoring of recent infection for incidence estimation and other public health applications.