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The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent. In marked contrast, the tempo of pathogen-specific CD4 T cell activation depended on whether the antigen was secreted or cell-associated. Furthermore, lymph node pathogen-specific CD4 T cell activation required CCR6 and cell migration from the site of infection. Surprisingly, adoptive transfer of wild-type blood phagocytes rescued bacteria-specific T cell activation in CCR6-deficient mice, even when these cells were unable to participate in direct antigen presentation. These data demonstrate that T cell responses to a local bacterial infection follow a distinct tempo, largely determined by bacterial protein secretion, and that CCR6-mediated blood phagocyte recruitment to the site of infection is a critical step in the initiation of pathogen-specific immune responses in skin draining lymph nodes.

Financial stress is a condition that occurs commonly in the United States, especially in single-mothers and their children. This stress can be a barrier to optimal health and wellness. In an effort to reduce financial stress and improve money management skills in low income, single mother families, the Financial Success Program (FSP) was created. This novel program provides education and support to an underserved population and may also improve the health and well-being of the women and children enrolled. Through a unique interprofessional collaboration, a study was initiated to assess the effect of financial education on health indicators in single-mother families. A thorough discussion of the FSP and interprofessional model will be discussed as a framework for addressing public health needs in a financially stressed population.