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We present the performances of a 330 g zinc molybdate (ZnMoO 4 ) crystal working as scintillating bolometer as a possible candidate for a next generation experiment to search for neutrinoless double beta decay of 100 Mo. The energy resolution, evaluated at the 2615 keV γ -line of 208 Tl, is 6.3 keV FWHM. The internal radioactive contaminations of the ZnMoO 4 were evaluated as <6 μBq/kg ( 228 Th) and 27±6 μBq/kg ( 226 Ra). We also present the results of the α vs β / γ discrimination, obtained through the scintillation light as well as through the study of the shape of the thermal signal alone.

CUORE, an array of 988 TeO 2 bolometers, is about to be one of the most sensitive experiments searching for neutrinoless double-beta decay. Its sensitivity could be further improved by removing the background from α radioactivity. A few years ago it was pointed out that the signal from β s can be tagged by detecting the emitted Cherenkov light, which is not produced by α s. In this paper we confirm this possibility. For the first time we measured the Cherenkov light emitted by a CUORE crystal, and found it to be 100 eV at the Q -value of the decay. To completely reject the α background, we compute that one needs light detectors with baseline noise below 20 eV RMS, a value which is 3–4 times smaller than the average noise of the bolometric light detectors we are using. We point out that an improved light detector technology must be developed to obtain TeO 2 bolometric experiments able to probe the inverted hierarchy of neutrino masses.

The LUCIFER project aims at deploying the first array of enriched scintillating bolometers for the investigation of neutrinoless double-beta decay of [Formula: see text]Se. The matrix which embeds the source is an array of ZnSe crystals, where enriched [Formula: see text]Se is used as decay isotope. The radiopurity of the initial components employed for manufacturing crystals, that can be operated as bolometers, is crucial for achieving a null background level in the region of interest for double-beta decay investigations. In this work, we evaluated the radioactive content in 2.5 kg of 96.3 % enriched [Formula: see text]Se metal, measured with a high-purity germanium detector at the Gran Sasso deep underground laboratory. The limits on internal contaminations of primordial decay chain elements of [Formula: see text]Th, [Formula: see text]U and [Formula: see text]U are respectively: [Formula: see text]61, [Formula: see text]110 and [Formula: see text]74 [Formula: see text]Bq/kg at 90 % C.L. The extremely low-background conditions in which the measurement was carried out and the high radiopurity of the [Formula: see text]Se allowed us to establish the most stringent lower limits on the half-lives of the double-beta decay of [Formula: see text]Se to 0[Formula: see text], 2[Formula: see text] and 2[Formula: see text] excited states of [Formula: see text]Kr of 3.4[Formula: see text]10[Formula: see text], 1.3[Formula: see text]10[Formula: see text] and 1.0[Formula: see text]10[Formula: see text] y, respectively, with a 90 % C.L.

The LUCIFER project aims at deploying the first array of enriched scintillating bolometers for the investigation of neutrinoless double-beta decay of Se-82. The matrix which embeds the source is an array of ZnSe crystals, where enriched Se-82 is used as decay isotope. The radiopurity of the initial components employed for manufacturing crystals, that can be operated as bolometers, is crucial for achieving a null background level in the region of interest for double-beta decay investigations. In this work, we evaluated the radioactive content in 2.5 kg of 96.3 % enriched Se-82 metal, measured with a high-purity germanium detector at the Gran Sasso deep underground laboratory. The limits on internal contaminations of primordial decay chain elements of Th-232, U-238 and U-235 are respectively: <61,<110 and <74 mu Bq/kg at 90 % C.L. The extremely low-background conditions in which the measurement was carried out and the high radiopurity of the Se-82 allowed us to establish the most stringent lower limits on the half-lives of the double-beta decay of Se-82 to 0(+)(1), 2(2)(+) and 2(1)(+) excited states of Kr-82 of 3.4.10(22), 1.3.10(22) and 1.0.10(22) y, respectively, with a 90 % C.L.

The production of ultra-pure raw material is a crucial step to ensure the required background level in rare event searches. In this work, we establish an innovative technique developed to produce high-purity (99.999%) granular zinc. We demonstrate the effectiveness of the refining procedure by measuring the internal contaminations of the purified zinc with a high-purity germanium detector at the Laboratori Nazionali del Gran Sasso. The total activity of cosmogenic activated nuclides is measured at the level of a few mBq/kg, as well as limits on naturally occurring radionuclides are set to less than mBq/kg. The excellent radiopurity of the zinc sample allows us to search for electron capture with positron emission and neutrinoless double electron capture of 64Zn, setting the currently most stringent lower limits on their half-lives, T1/2εβ+>2.7×1021year (90% CI), and T1/20ν2ε>2.6×1021year (90% CI), respectively.

The 1-ton-scale CUORE detector is made of 988 TeO 2 crystals operated as cryogenic bolometers at a working temperature of ∼ 10 mK . In order to provide the necessary cooling power at 4 K stage, a total of five pulse tube (PT) refrigerators are used. The PTs make the cryogenic system reliable and stable, but have the downside that mechanical vibrations at low frequencies (1.4 Hz and related harmonics) are injected into the experimental apparatus. An active noise cancellation technique has been developed in order to reduce such effect by taking advantage from the coherent interference of the pressure oscillations originated by the different PTs. The technique that will be presented consists in controlling the relative phases of the pressure waves running inside the CUORE PT lines, in order to achieve the lowest detector noise. By reducing the power of PT harmonics by a factor up to 10 4 , it drastically suppresses the overall noise RMS on the CUORE detector. In the following, we demonstrate the reliability and effectiveness of the technique, showing that the optimization of the detector noise level is possible in different experimental conditions.

Patient safety and treatment outcome could be improved if physicians could rapidly control the activity of therapeutic agents in their patients. Antidote control is the safest way to regulate drug activity, because unlike rapidly clearing drugs, control of the drug activity is independent of underlying patient physiology and co-morbidities. Until recently, however, there was no general method to discover antidote-controlled drugs. Here we demonstrate that the activity and side effects of a specific class of drugs, called aptamers, can be controlled by matched antidotes in vivo . The drug, an anticoagulant aptamer, systemically induces anticoagulation in pigs and inhibits thrombosis in murine models. The antidote rapidly reverses anticoagulation engendered by the drug, and prevents drug-induced bleeding in surgically challenged animals. These results demonstrate that rationally designed drug-antidote pairs can be generated to provide control over drug activities in animals.

In the field of fundamental particle physics, the neutrino has become more and more important in the last few years, since the discovery of its mass. In particular, the ultimate nature of the neutrino (if it is a Dirac or a Majorana particle) plays a crucial role not only in neutrino physics, but also in the overall framework of fundamental particle interactions and in cosmology. The only way to disentangle its ultimate nature is to search for the neutrinoless double beta decay. The idea of LUCIFER is to combine the bolometric technique proposed for the CUORE experiment with the bolometric light detection technique used in cryogenic dark matter experiments. The bolometric technique allows an extremely good energy resolution while its combination with the scintillation detection offers an ultimate tool for background rejection. The goal of LUCIFER is not only to build a background-free small-scale experiment but also to directly prove the potentiality of this technique. Preliminary tests on several detectors containing different interesting DBD emitters have clearly demonstrated the excellent background rejection capabilities that arise from the simultaneous, independent, double readout of heat and scintillation light.

Progestogens [progesterone (P(4)) and its products] play fundamental roles in the development and/or function of the central nervous system during pregnancy. We, and others, have investigated the role of pregnane neurosteroids for a plethora of functional effects beyond their pro-gestational processes. Emerging findings regarding the effects, mechanisms, and sources of neurosteroids have challenged traditional dogma about steroid action. How the P(4) metabolite and neurosteroid, 3α-hydroxy-5α-pregnan-20-one (3α,5α-THP), influences cellular functions and behavioral processes involved in emotion/affect, motivation, and reward, is the focus of the present review. To further understand these processes, we have utilized an animal model assessing the effects, mechanisms, and sources of 3α,5α-THP. In the ventral tegmental area (VTA), 3α,5α-THP has actions to facilitate affective, and motivated, social behaviors through non-traditional targets, such as GABA, glutamate, and dopamine receptors. 3α,5α-THP levels in the midbrain VTA both facilitate, and/or are enhanced by, affective and social behavior. The pregnane xenobiotic receptor (PXR) mediates the production of, and/or metabolism to, various neurobiological factors. PXR is localized to the midbrain VTA of rats. The role of PXR to influence 3α,5α-THP production from central biosynthesis, and/or metabolism of peripheral P(4), in the VTA, as well as its role to facilitate, or be increased by, affective/social behaviors is under investigation. Investigating novel behavioral functions of 3α,5α-THP extends our knowledge of the neurobiology of progestogens, relevant for affective/social behaviors, and their connections to systems that regulate affect and motivated processes, such as those important for stress regulation and neuropsychiatric disorders (anxiety, depression, schizophrenia, drug dependence). Thus, further understanding of 3α,5α-THP's role and mechanisms to enhance affective and motivated processes is essential.