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Young EU migrants in London in the transition to Brexit
\"London has long been a magnet for migrants, millions of whom have been attracted by its economic, educational and cultural roles as a truly global city. This book examines recent European migration to the London region through the narrated experiences of a large number of younger migrants from 'old' and 'new' EU member states, of varying educational and skill backgrounds. The research opens multiple windows into the lives of young EU migrants from six different countries before and after the 2016 Referendum on 'Brexit'. A key concept which lies at the core of the analysis is the interrelationship between geographical mobility and the youth transition to adulthood. Among the dimensions documented are study and employment trajectories, housing and social inclusion, identity and belonging, and transnational ties. By paying attention to young people's own accounts of their mobile lives, the research pushes the boundaries of traditional understandings of youth transitions and life-paths. As an indispensable account of young EU migrants during the Brexit process, the book will appeal to undergraduate and postgraduate students across the social sciences, especially those interested in migration, youth studies and European Studies, as well as researchers and policy-makers\"-- Provided by publisher.
BOOK
Life Story Interviewing as a Method to Co-Construct Narratives About Resilience
Human life presents many unplanned twists and turns. No one escapes this world without facing adversity of some kind. Therefore, the value in teaching and researching resilience cannot be overstated. This research explores how life story interviewing with interactive methods (also referred to as “elicitation techniques”) provides an invaluable approach to investigating and understanding resilience. Specifically, a stepwise framework is offered for researching resilience as a co-constructed, relational phenomenon. Upon applying this framework through teaching an undergraduate senior seminar, I offer thematic observations of my students’ interviewing experiences to show how life storytelling promotes (a) embodied understandings of resilience, (b) an appreciation for others’ unique differences, and (c) strengthened relationships between interviewees and interviewers. These findings show promise for future teachers and researchers interested in exploring the relational benefits made possible through creative storytelling methods. The methods proposed in this study not only provide a means for exploring conceptualizations of resilience; in and of themselves, they enact resilience.
Journal Article
The GBIF Integrated Publishing Toolkit: Facilitating the Efficient Publishing of Biodiversity Data on the Internet
The planet is experiencing an ongoing global biodiversity crisis. Measuring the magnitude and rate of change more effectively requires access to organized, easily discoverable, and digitally-formatted biodiversity data, both legacy and new, from across the globe. Assembling this coherent digital representation of biodiversity requires the integration of data that have historically been analog, dispersed, and heterogeneous. The Integrated Publishing Toolkit (IPT) is a software package developed to support biodiversity dataset publication in a common format. The IPT's two primary functions are to 1) encode existing species occurrence datasets and checklists, such as records from natural history collections or observations, in the Darwin Core standard to enhance interoperability of data, and 2) publish and archive data and metadata for broad use in a Darwin Core Archive, a set of files following a standard format. Here we discuss the key need for the IPT, how it has developed in response to community input, and how it continues to evolve to streamline and enhance the interoperability, discoverability, and mobilization of new data types beyond basic Darwin Core records. We close with a discussion how IPT has impacted the biodiversity research community, how it enhances data publishing in more traditional journal venues, along with new features implemented in the latest version of the IPT, and future plans for more enhancements.
Journal Article
When distance enhances closeness
Exploring international students’ long-distance relationships with their back-home families is important for understanding how to support their stability and growth. Using qualitative interviews and surveys, this research explored perspectives from both international students and their parents about their remote interactions while oceans apart. Findings indicate three transformative shifts that enhanced the quality of student-parent relationships through their distance: a) incidental to intentionally motivated interactions, b) task-oriented to person-centered attention, and c) authoritarian to communally-oriented dispositions. These shifts fostered a greater sense of trust, support, and intimacy between international students and their back-home parents. Interweaving Construal Level Theory with the findings, this study offers implications for informing international students and their parents on developing effective, long-distance relationships.
Journal Article
Tolerability of oral itraconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A systematic review and meta-analysis
Chronic pulmonary aspergillosis (CPA) requires prolonged treatment with itraconazole or voriconazole. However, adverse events (AEs) are common with the use of these agents, with the need to discontinue the offending drug in a significant proportion of the patients. The aim of this study was to evaluate the frequency of adverse events of itraconazole and voriconazole for the treatment of CPA.
We searched Embase and Medline to select clinical studies providing information on AEs to itraconazole or voriconazole for the treatment of CPA from inception to May 2020. Reviews, single case reports, and case series reporting less than 10 patients were excluded. Random effect meta-analysis was performed using STATA 16.0.
We included 9 eligible studies with an overall total of 534 CPA patients enrolled. Of these, 69% (n = 366) were treated with voriconazole and 31% (n = 168) with itraconazole. The median daily dose of both itraconazole and voriconazole used was 400mg. In a pooled analysis, AEs were observed in 36% (95% CI: 20-52%, N = 366) of patients on voriconazole and 25% (95% CI: 18 to 31%, N = 168) in those treated with itraconazole. Discontinuation rate due to AEs was the same for both drugs; 35% (47/366) and 35% (15/168) for voriconazole and itraconazole, respectively. There were 70 AEs reported with itraconazole use, the commonest being cardiotoxicity (29%). Skin AEs (28%) were the most frequent among the 204 AEs reported with voriconazole use. None of the studies compared the tolerability of itraconazole head-to-head with voriconazole.
AEs due itraconazole and voriconazole are common and may lead to discontinuation of treatment in a significant proportion of patients. This information can be used to educate patients prior to commencement of these antifungal therapies.
CRD42020191627.
Journal Article
Variant discovery using next-generation sequencing and its future role in pharmacogenetics
Next-generation sequencing (NGS) has enabled the discovery of a multitude of novel and mostly rare variants in pharmacogenes that may alter a patient’s therapeutic response to drugs. In addition to single nucleotide variants, structural variation affecting the number of copies of whole genes or parts of genes can be detected. While current guidelines concerning clinical implementation mostly act upon well-documented, common single nucleotide variants to guide dosing or drug selection,
and large-scale functional assessment of rare variant effects on protein function are at the forefront of pharmacogenetic research to facilitate their clinical integration. Here, we discuss the role of NGS in variant discovery, paving the way for more comprehensive genotype-guided pharmacotherapy that can translate to improved clinical care.
Journal Article
Relational storytelling and critical reflections on difference
This essay explores unique practices for teaching relational ethics through storytelling. Drawing from my experiences teaching an advanced undergraduate Narrative Ethics seminar, I explain how my students responded to a storytelling unit through which they examined their values and storytelling ethics. I interweave observations from my teaching with insights gathered from my students' in-class discussions and written reflections to demonstrate the pedagogical aims, outcomes, and challenges encountered when engaging this material. I focus particularly on offering suggestions for encouraging students to (a) embrace limits to their understandings of others and (b) recognize how listening for, and expressing, difference plays a fundamental role in their personal, relational, and ethical growth.
Journal Article
Uptake and impact of journaling program on wellbeing of NICU parents
ObjectiveThis pilot study evaluated a brief parent journaling program in the neonatal intensive care unit (NICU).Study designHundred NICU parents were randomized to a control group (no journal) or an intervention group (journal provided). Parents reported pre- and post-intervention anxiety and depression symptoms using the hospital anxiety and depression scale (HADS) and qualitative journal use data. The analysis included Student’s paired two-tailed t-test and two-way ANOVA. This study was registered with clinicaltrials.gov on April 1, 2020, NCT04331925.ResultAt baseline, clinically significant anxiety was more prevalent than depression (66% vs. 23%). Post-intervention scores were best predicted by baseline scores. Relative to controls, intervention group parents experienced a decrease in anxiety from baseline (t = −1.983, p = 0.056). The same effect was not seen for depression. Most intervention group parents used the journal and provided positive feedback.ConclusionJournal use rates and positive feedback support the acceptability of a NICU journaling program.
Journal Article
Stakeholder identified research priorities for early intervention in psychosis
Background
Public resources to answer pertinent research questions about the impact of illness and treatment on people with mental health problems are limited. To target funds effectively and efficiently and maximize the health benefits to populations, prioritizing research areas is needed. Research agendas are generally driven by researcher and funder priorities, however, there is growing recognition of the need to include user‐defined research priorities to make research more relevant, needs‐based and efficient.
Objective
To gain consensus on top priorities for research into early intervention in psychosis through a robust, democratic process for prioritization enlisting the views of key stakeholders including users, carers and healthcare professionals. We also sought to determine which user‐prioritized questions were supported by scientific evidence.
Design and Methods
We used a modified nominal group technique to gain consensus on unanswered questions that were obtained by survey and ranked at successive stages by a steering group comprising users, carer representatives and clinicians from relevant disciplines and stakeholder bodies. We checked each question posed in the survey was unanswered in research by reviewing evidence in five databases (Medline, Cinahl, PsychInfo, EMBASE and Cochrane Database).
Results
Two hundred and eighty‐three questions were submitted by 207 people. After checking for relevance, reframing and examining for duplicates, 258 questions remained. We gained consensus on 10 priority questions; these largely represented themes around access and engagement, information needs before and after treatment acceptance, and the influence of service‐user (SU) priorities and beliefs on treatment choices and effectiveness. A recovery SUtheme identified specific self‐management questions and more globally, a need to fully identify factors that impact recovery.
Discussion and Conclusions
Published research findings indicated that the priorities of service users, carers and healthcare professionals were aligned with researchers' and funders' priorities in some areas and misaligned in others providing vital opportunities to develop research agendas that more closely reflect users' needs.
Patient and Public Contribution
Initial results were presented at stakeholder workshops which included service‐users, carers, health professionals and researchers during a consensus workshop to prioritize research questions and allow the opportunity for feedback. Patient and public representatives formed part of the steering group and were consulted regularly during the research process.
Journal Article