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"Russo, Alessandra, author"
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Color Atlas of Endo-Otoscopy
A powerful guide to the primary diagnosis of disorders of the external auditory canal, tympanic membrane, middle ear, temporal bone, and skull base
Despite the many advances in diagnostic technologies and imaging modalities in recent years, otoscopy remains the first diagnostic option in the diagnosis of otologic disease.
This is an easy-to-consult book for residents and specialists, featuring brilliant diagnostic images from the newest generation of endoscopic otoscopes. Written by a renowned team of experts with 30 years of experience, this book helps readers obtain proficiency in otoscopy and in the interpretation of findings. Readers will learn what clinical consequences the diagnoses may have through case examples and treatment suggestions.
Key Features:
* Richly illustrated with over 1000 mostly full-color photographs and many radiological studies
* Shows a vast range of common and rare pathologies that can be visualized and assessed via endo-otoscopy
* Juxtaposes, when appropriate, the clinical picture, radiological diagnosis, and intraoperative findings with the endo-otoscopic findings of the patient
* In each chapter, a surgical summary lists various approaches that may be used to optimally plan treatment of the patient
* A special final chapter covers the assessment of postsurgical findings as seen in otoscopy, so as to distinguish between normal healing and changes that may require further intervention
Color Atlas of Endo-Otoscopy, produced with the support of Mario Sanna Foundation, is certain to become a valuable tool for all physicians involved in the care of patients with ear ailments.
eBook
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
Background
BRCA1
and, more commonly,
BRCA2
mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with
BRCA1/2
mutations. Using the largest available dataset, we determined whether MBCs arising in
BRCA1/2
mutation carriers display specific pathologic features and whether these features differ from those of
BRCA1/2
female BCs (FBCs).
Methods
We characterised the pathologic features of 419
BRCA1/2
MBCs and, using logistic regression analysis, contrasted those with data from 9675
BRCA1/2
FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database.
Results
Among
BRCA2
MBCs, grade significantly decreased with increasing age at diagnosis (
P
= 0.005). Compared with
BRCA2
FBCs,
BRCA2
MBCs were of significantly higher stage (
P
for trend = 2 × 10
−5
) and higher grade (
P
for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared
BRCA1
MBCs and FBCs.
BRCA2
MBCs also presented with higher grade than MBCs from the SEER database (
P
for trend = 4 × 10
−12
).
Conclusions
On the basis of the largest series analysed to date, our results show that
BRCA1
/
2
MBCs display distinct pathologic characteristics compared with
BRCA1
/
2
FBCs, and we identified a specific
BRCA2-
associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.
Journal Article
