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The conceptual assessment of the rating conditions of power cables was addressed over one century ago, with theories based on the physical and heat transfer properties of the power cable installed in a given medium. During the years, the evolution of the computational methods and technologies has made more powerful means for executing the calculations available. More detailed configurations have been analysed, also moving from the steady-state to dynamic rating assessment. The research is in progress, with recent advances obtained on both advanced models, extensive calculations from 2D and 3D finite element methods, simplified approaches aimed at reducing the computational burden, and dedicated solutions for specific types of cables and applications. This paper provides a general overview that links the fundamental concepts of heat transfer for the calculation of cable rating to the advanced solutions that have emerged in the last years.

Inherited retinal dystrophies and late-stage age-related macular degeneration, for which treatments remain limited, are among the most prevalent causes of legal blindness. Retinal prostheses have been developed to stimulate the inner retinal network; however, lack of sensitivity and resolution, and the need for wiring or external cameras, have limited their application. Here we show that conjugated polymer nanoparticles (P3HT NPs) mediate light-evoked stimulation of retinal neurons and persistently rescue visual functions when subretinally injected in a rat model of retinitis pigmentosa. P3HT NPs spread out over the entire subretinal space and promote light-dependent activation of spared inner retinal neurons, recovering subcortical, cortical and behavioural visual responses in the absence of trophic effects or retinal inflammation. By conferring sustained light sensitivity to degenerate retinas after a single injection, and with the potential for high spatial resolution, P3HT NPs provide a new avenue in retinal prosthetics with potential applications not only in retinitis pigmentosa, but also in age-related macular degeneration.Semiconducting polymer nanoparticles can act as light-sensitive interfaces with retinal neurons, and on microinjection in the eye, rescue vision in retinas affected by photoreceptor degeneration, offering a potential new treatment option for inherited retinal dystrophies and late-stage age-related macular degeneration.

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1-mediated H3K9me3 and DNA methylation. However, the protein network which regulates the deposition of these chromatin modifications is still incompletely understood. Here, we perform a genome-wide single guide RNA (sgRNA) screen for genes involved in ERV silencing and identify the GHKL ATPase protein Morc3 as a top-scoring hit. Morc3 knock-out (ko) cells display de-repression, reduced H3K9me3, and increased chromatin accessibility of distinct ERV families. We find that the Morc3 ATPase cycle and Morc3 SUMOylation are important for ERV chromatin regulation. Proteomic analyses reveal that Morc3 mutant proteins fail to interact with the histone H3.3 chaperone Daxx. This interaction depends on Morc3 SUMOylation and Daxx SUMO binding. Notably, in Morc3 ko cells, we observe strongly reduced histone H3.3 on Morc3 binding sites. Thus, our data demonstrate Morc3 as a critical regulator of Daxx-mediated histone H3.3 incorporation to ERV regions. Endogenous retroviruses (ERVs) compose a significant portion of mammalian genomes; however, how ERVs are regulated is not well known. Here the authors performed a genome-wide sgRNA screen to identify Morc3 as a mediator of ERV silencing. They show Morc3 associates with the H3.3 chaperone Daxx, and that loss of Morc3 leads to reduced H3.3 at ERVs.

With the increase in the electrical load and the progressive introduction of power generation from intermittent renewable energy sources, the power line operating conditions are approaching the thermal limits. The definition of thermal limits variable in time has been addressed under the concept of dynamic thermal rating (DTR), with which it is possible to provide a more detailed assessment of the line rating and exploit the electrical system more flexibly. Most of the literature on DTR has addressed overhead lines exposed to different weather conditions. The interest in the dynamic thermal rating of power cables is increasing, considering the evolution of computational methods and advanced systems for cable monitoring. This paper contains an overview of the concepts and methods referring to dynamic cable rating (DCR). Starting from the analytical formulations developed many years ago for determining the power cable rating in steady-state conditions, also reported in International Standards, this paper considers the improvements of these formulations proposed during the years. These improvements are leading to include more specific details in the models used for DCR analysis and the computational methods used to assess the power cable’s thermal conditions buried in soil. This paper is focused on highlighting the path from the initial theories and models to the latest literature contributions. Attention is paid to thermal modelling with different levels of detail, applications of 2D and 3D solvers and simplified models, and their validation based on experimental measurements. A salient point of the overview is considering the DCR impact on reliability aspects, risk estimation, real-time calculations, forecasting, and planning with different time horizons.

Organizations must quickly adapt their processes to understand the dynamic nature of modern business environments. As highlighted in the literature, centralized governance supports decision-making and performance measurement processes in technology companies. For this reason, a reliable decision-making system with an integrated data model that enables the rapid collection and transformation of data stored in heterogeneous and different sources is needed. Therefore, this paper proposes the design of a data model to implement data-driven governance through a literature review of adopted approaches. The lack of a standardized procedure and a disconnection between theoretical frameworks and practical application has emerged. This paper documented the suggested approach following these steps: (i) mapping of monitoring requirements to the data structure, (ii) documentation of ER diagram design, and (iii) reporting dashboards used for monitoring and reporting. The paper helped fill the gaps highlighted in the literature by supporting the design and development of a DWH data model coupled with a BI system. The application prototype shows benefits for top management, particularly those responsible for governance and operations, especially for risk monitoring, audit compliance, communication, knowledge sharing on strategic areas of the company, and identification and implementation of performance improvements and optimizations.

The characterisation of power curves for individual household appliances needs to consider technical and user behaviour-based aspects. To assess the impact of an aggregation of appliances, the combination of non-synchronised power curves of multiple appliances with different types of usage in different households has to be represented. This article sets up a framework of analysis that incorporates survey-based indications on the user’s behaviour, taken from a dedicated questionnaire, and the measured characteristics of main appliances with user-based activation. A Monte Carlo approach is formulated to determine the specific contribution of a given number of similar appliances to the aggregate power curve. Examples are shown, considering examples taken from the aggregate usage of washing machines and dishwashers as two exemplificative types of main household appliances with user-based activation. The analysis is then extended to power curves defined with different time steps to determine indications such as the peak power and the 99% and 95% non-exceeding probability of the aggregate demand for the same type of appliances. The availability of information on the aggregation of the main appliances is useful to refine demand response programmes and assess the interaction between appliances, local generation and local storage in the household.

The instability of structures due to compression is one of the most critical issues related to aircraft components. Especially in composite materials, which have poor out-of-plane mechanical properties, the buckling load must be assessed to ensure that the structures are within the safe limits compared to the operating loads. In the presence of delamination, the compression instability of structures becomes catastrophic, as the propagation of delamination can dramatically reduce the stiffness of the structure almost instantaneously. During the operational life of composite aircraft components, one of the most common events that can occur is low-velocity impact with foreign objects, which is one of the primary reasons for delamination. In this paper, a sensitivity analysis is presented on a typical aerospace reinforced panel with a circular delamination, representative of an impact damage. Different configurations have been analysed, varying the radius and position along the thickness of the delamination. Furthermore, some geometric parameters of the panel have been modified to evaluate how the buckling load and the propagation of interlaminar damage evolve.

The COVID-19 pandemic has negatively influenced the psychological well-being of people around the world; university students have experienced feelings of fear of the COVID-19 pandemic, due to the intolerance of uncertainty, and a worsened quality of life, related to the reduction of social contacts. Scholars all around the world widely suggest the need to take care of this issue, proposing solutions to support students’ adjustment in the post-pandemic period. The literature on positive psychology and the life design approach has identified multiple psychological resources, the character strengths, that can sustain people’s life satisfaction and well-being in changing contexts, including their university experience. We proposed an online group career counseling intervention for 30 Italian university students (experimental group) to promote university students’ psychological resources and mitigate the long-term negative implications of the COVID-19 pandemic on life satisfaction. The other 30 students formed the control group. We found that the students engaged in the online group career counseling intervention evidenced, at the post-test, higher levels than the pre-test of (a) resilience, (b) subjective risk intelligence, (c) career adaptability, (d) self-efficacy, (e) optimism, (f) hope, (g) life satisfaction, and lower levels than the pre-test of (h) fears of COVID-19 pandemic. No differences at Time 1 and Time 2 were found in the control group. Implications for future research and practice will be discussed.

Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modifications H3K9me3 and DNA methylation. On ERVs, these modifications are mainly deposited by the histone methyltransferase Setdb1 and by the maintenance DNA methyltransferase Dnmt1 . Knock-out of either Setdb1 or Dnmt1 leads to ERV de-repression in various cell types. However, it is currently not known if H3K9me3 and DNA methylation depend on each other for ERV silencing. Here we show that conditional knock-out of Setdb1 in mouse embryonic endoderm results in ERV de-repression in visceral endoderm (VE) descendants and does not occur in definitive endoderm (DE). Deletion of Setdb1 in VE progenitors results in loss of H3K9me3 and reduced DNA methylation of Intracisternal A-particle ( IAP ) elements, consistent with up-regulation of this ERV family. In DE, loss of Setdb1 does not affect H3K9me3 nor DNA methylation, suggesting Setdb1 -independent pathways for maintaining these modifications. Importantly, Dnmt1 knock-out results in IAP de-repression in both visceral and definitive endoderm cells, while H3K9me3 is unaltered. Thus, our data suggest a dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm cells. Our findings suggest that Setdb1-meditated H3K9me3 is not sufficient for IAP silencing, but rather critical for maintaining high DNA methylation. Silencing of endogenous retroviruses is crucial for maintaining transcriptional and genomic integrity of cells and is maintained by histone H3K9 methylation and/or DNA methylation in various cell types. Here the authors show that loss of DNA methyltransferase DNMT1 in endoderm results in ERV derepression while H3K9me3 is unaltered.

Background Building decent and sustainable career paths that promote the well-being of individuals and the community is a central challenge in vocational education and training contexts. Based on the life design paradigm, this study investigates the interconnectedness between the sense of community responsibility, decent work, sustainable careers, and overall well-being. Decent work refers to employment that is productive, fairly compensated, safe, inclusive, and socially just, while sustainable career prospects describe an individual’s perceived potential for a fulfilling, healthy, productive, and socially impactful career. We propose that a strong sense of community can shape the key aspects of personal and professional life, significantly influencing individuals’ decent and sustainable career development and their overall well-being. Methods The cross-sectional study included a sample of 250 working Italian participants (90 males, 160 females) aged 19 to 65, representing a diverse range of professional roles (employees, self-employed, trainees). The following instruments were administered: the Sense of Community Responsibility Scale, the Decent Work for the Inclusive and Sustainable Future Construction Scale, the Future Sustainable Career Scale, and the Mental Health Continuum–Short Form, assessing emotional, psychological, and social well-being. Two mediation models, total and partial, were tested using structural equation modeling. Results The mediation model’s results demonstrated that a sense of community responsibility predicted individuals’ perceived capacity to undertake decent work and develop future sustainable career prospects. Furthermore, the study found that these factors, in turn, significantly predicted emotional, psychological, and social well-being. Conclusions This study highlights the potential of cultivating a sense of community responsibility as a catalyst for individual and societal sustainable development cycles. By fostering a sense of community, career professionals can empower individuals to make career choices that align with decent work and sustainable career principles, ultimately leading to improved well-being for both individuals and communities. The findings underscore the importance of integrating community-focused strategies in vocational education and training, encouraging awareness of the social and environmental impacts of career choices.