Explore the vast range of titles available.

Little is known about the climate of the scientific fieldwork setting as it relates to gendered experiences, sexual harassment, and sexual assault. We conducted an internet-based survey of field scientists (N = 666) to characterize these experiences. Codes of conduct and sexual harassment policies were not regularly encountered by respondents, while harassment and assault were commonly experienced by respondents during trainee career stages. Women trainees were the primary targets; their perpetrators were predominantly senior to them professionally within the research team. Male trainees were more often targeted by their peers at the research site. Few respondents were aware of mechanisms to report incidents; most who did report were unsatisfied with the outcome. These findings suggest that policies emphasizing safety, inclusivity, and collegiality have the potential to improve field experiences of a diversity of researchers, especially during early career stages. These include better awareness of mechanisms for direct and oblique reporting of harassment and assault and, the implementation of productive response mechanisms when such behaviors are reported. Principal investigators are particularly well positioned to influence workplace culture at their field sites.

Numerous studies use quantitative measures to evaluate retention, advancement and success in academic settings. Such approaches, however, present challenges for evaluating the lived experiences of academics. Here, we present a qualitative thematic analysis of self-reports of positive and negative experiences that occurred while conducting academic field research. Twenty-six semistructured interviews highlighted two central themes: (1) variability in clarity of appropriate professional behavior and rules at fieldsites, and (2) access, or obstacles therein, to professional resources and opportunity. In some instances, respondent narratives recalled a lack of consequences for violations of rules governing appropriate conduct. These violations included harassment and assault, and ultimately disruptions to career trajectories. A heuristic construct of a traffic light describing Red, Yellow, and Green experiences illustrates the ramifications of this distribution of clarity and access within fieldsite contexts. These results extend the findings from our previously reported Survey of Academic Field Experiences (SAFE) about the climates and contexts created and experienced in field research settings. Moreover, this study addresses specific tactics, such as policies, procedures, and paradigms that fieldsite directors and principal investigators can implement to improve field experiences and better achieve equal opportunity in field research settings. Numerosos estudios usan medidas cuantitativas para evaluar la retención, el ascenso y el éxito en ámbitos académicos. Tales aproximaciones, sin embargo, presentan retos para evaluar las experiencias vividas por los académicos. Aquí presentamos un análisis temático cualitativo de los autoreportes de experiencias positivas y negativas que ocurrieron mientras conducían investigación de campo académica. Veintiséis entrevistas semiestructuradas destacaron dos temas centrales: (1) variabilidad en la claridad de la conducta profesional apropiada y las reglas de los sitios de campo, y (2) acceso, u obstáculos en él, a la oportunidad y los recursos profesionales. En algunas instancias, las narrativas de los respondedores recordaron una falta de consecuencias por las violaciones a las reglas que rigen la conducta apropiada. Estas violaciones incluyeron acoso y asalto, y finalmente disrupciones en las trayectorias de sus carreras. Un constructo heurístico de un semáforo que describe las experiencias de Rojo, Amarillo, y Verde ilustra las ramificaciones de esta distribución de claridad y acceso dentro de los contextos de los sitios de campo. Estos resultados extienden los hallazgos de nuestra Encuesta de las Experiencias de Campo Académicas (SAFE) previamente reportada acerca de los climas y contextos creados y experimentados en entornos de investigación de campo. Adicionalmente, este estudio aborda tácticas específicas, tales como políticas, procedimientos y paradigmas que los directores de sitios de campo e investigadores principales pueden implementar para mejorar las experiencias de campo y lograr de mejor manera la igualdad de oportunidades en sitios de investigación de campo.

We investigated associations between prenatal genocidal trauma, including maternal rape, and postnatal adverse childhood experiences (ACEs) on DNA methylation of genes associated with the stress response. In a comparative cross-sectional study of 91 Rwandan young adults, categorized by prenatal exposure to genocide and maternal rape, genocide without rape, and unexposed controls, we analyzed DNA methylation from dried blood spots and assessed ACEs and depression and anxiety symptoms at age 24. Prenatal exposure to maternal rape was associated with DNA methylation changes in BDNF and SLC6A4 , with the association in BDNF attenuated after including ACE exposure in the model. Genocide exposure without rape was associated with methylation changes in PRDM8 after adjusting for early adversity. Methylation in BDNF and SLC6A4 correlated with depression and anxiety symptoms. These findings underscore the impact of prenatal and postnatal trauma on DNA methylation and mental wellbeing, emphasizing the need for continued support for survivors in the decades after conflict.

A singular focus on maternal health at the time of a pregnancy leaves much about perinatal mortality unexplained, especially when there is growing evidence for maternal early life effects. Further, lumping stillbirth and early neonatal death into a single category of perinatal mortality may obscure different causes and thus different avenues of screening and prevention. The common marmoset monkey ( Callithrix jacchus ), a litter-bearing nonhuman primate, is an ideal species in which to study the independent effects of a mother’s early life and adult phenotypes on pregnancy outcomes. We tested two hypotheses in 59 marmoset pregnancies at the Southwest National Primate Research Center and the Barshop Institute for Longevity and Aging Studies. We explored 1) whether pregnancy outcomes were predicted independently by maternal adult weight versus maternal litter size and birth weight, and 2) whether stillbirth and early neonatal death were differentially predicted by maternal variables. No maternal characteristics predicted stillbirth and no maternal adult characteristics predicted early neonatal death. In univariate Poisson models, triplet-born females had a significantly increased rate of early neonatal death (IRR[se] = 3.00[1.29], p = 0.011), while higher birth weight females had a decreased rate (IRR[se] = 0.89[0.05], p = 0.039). In multivariate Poisson models, maternal litter size remained an independent predictor, explaining 13% of the variance in early neonatal death. We found that the later in the first week those neonates died, the more weight they lost. Together these findings suggest that triplet-born and low birth weight females have distinct developmental trajectories underlying greater rates of infant loss, losses that we suggest may be attributable to developmental disruption of infant feeding and carrying. Our findings of early life contributions to adult pregnancy outcomes in the common marmoset disrupt mother-blaming narratives of pregnancy outcomes in humans. These narratives hold that the pregnant person is solely responsible for pregnancy outcomes and the health of their children, independent of socioecological factors, a moralistic framing that has shaped clinical pregnancy management. It is necessary to differentiate temporal trajectories and causes of perinatal loss and view them as embedded in external processes to develop screening, diagnostic, and treatment tools that consider the full arc of a mother’s lived experience, from womb to womb and beyond.

New World monkeys (NWMs) are characterized by an extensive size range, with clawed NWMs (subfamily Callitrichinae, or callitrichines) such as the common marmoset manifesting diminutive size and unique reproductive adaptations. Perhaps the most notable of these adaptations is their propensity toward multiple gestations (i.e., dichorionic twins and trichorionic triplets). Indeed, with the exception of Goeldi’s monkey (Callimico), callitrichine singleton pregnancies rarely occur. Multiple gestations seem to have coevolved with a suite of reproductive adaptations, including hematopoetic chimerism of siblings, suppression of reproduction in nondominant females, and cooperative alloparenting. The sequencing of the common marmoset (Callithrix jacchus) genome offers the opportunity to explore the genetic basis of these unusual traits within this primate lineage. In this study, we hypothesized that genetic changes arising during callitrichine evolution resulted in multiple ovulated ova with each cycle, and that these changes triggered adaptations that minimized complications common to multiple gestations in other primates, including humans. Callitrichine-specific nonsynonymous substitutions were identified in GDF9 , BMP15, BMP4 , and WFIKKN1 . WFIKKN1, a multidomain protease inhibitor that binds growth factors and bone morphogenetic proteins, has nonsynonymous changes found exclusively in common marmosets and other tested callitrichine species that twin. In the one callitrichine species that does not produce twins (Callimico), this change has reverted back to the ancestral (nontwinning) primate sequence. Polymorphisms in GDF9 occur among human cohorts with a propensity for dizygotic twins, and polymorphisms in GDF9 and BMP15 are associated with twinning in sheep. We postulate that positive selection affected NWM growth patterns, with callitrichine miniaturization coevolving with a series of reproductive adaptations.

Ecological factors are important determinants of the development and function of anti-pathogen defences. Inflammation is a central part of innate immunity, but the developmental factors that shape the regulation of inflammation are not known. We test the hypothesis that microbial exposures in infancy are associated with high sensitivity C-reactive protein (CRP) in adulthood using prospective data from a birth cohort in the Philippines (n = 1461). Lower birth weight was associated with increased CRP, consistent with a role for inflammation in the widely documented inverse relationship between birth weight and adult cardiovascular diseases. In addition, higher levels of microbial exposure in infancy were associated with lower CRP. These associations were independent of socioeconomic status, measures of current body fat and other health behaviours. We conclude that measures of microbial exposure and nutrition during the pre-natal and early post-natal periods are important predictors of CRP concentration in young adulthood. We speculate that the development of anti-inflammatory regulatory networks in response to early microbial exposure represents plasticity in the development of anti-pathogen defences, and that this process may help explain the low CRP concentrations in this population.

The impact of the intrauterine environment on the developmental programming of adult female reproductive success is still poorly understood and potentially underestimated. Litter size variation in a nonhuman primate, the common marmoset monkey (Callithrix jacchus), allows us to model the effects of varying intrauterine environments (e.g. nutrient restriction, exposure to male womb-mates) on the risk of losing fetuses in adulthood. Our previous work has characterized the fetuses of triplet pregnancies as experiencing intrauterine nutritional restriction. We used over a decade of demographic data from the Southwest National Primate Research Center common marmoset colony. We evaluated differences between twin and triplet females in the number of pregnancies they produce and the proportion of those pregnancies that ended in fetal loss. We found that triplet females produced the same number of total offspring as twin females, but lost offspring during pregnancy at a significantly higher rate than did twins (38% vs. 13%, p = 0.02). Regardless of their own birth weight or the sex ratio of the litter the experienced as fetuses, triplet females lost more fetuses than did twins. Females with a male littermate experienced a significant increase in the proportion of stillbirths. These striking findings anchor pregnancy loss in the mother's own fetal environment and development, underscoring a \"Womb to Womb\" view of the lifecourse and the intergenerational consequences of development. This has important translational implications for understanding the large proportion of human stillbirths that are unexplained. Our findings provide strong evidence that a full understanding of mammalian life history and reproductive biology requires a developmental foundation.

During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. However, understanding the underlying pathogenesis of ZIKV congenital disease has been hampered by a lack of relevant in vivo experimental models. Here we present a candidate New World monkey model of ZIKV infection in pregnant marmosets that faithfully recapitulates human disease. ZIKV inoculation at the human-equivalent of early gestation caused an asymptomatic seroconversion, induction of type I/II interferon-associated genes and proinflammatory cytokines, and persistent viremia and viruria. Spontaneous pregnancy loss was observed 16–18 days post-infection, with extensive active placental viral replication and fetal neurocellular disorganization similar to that seen in humans. These findings underscore the key role of the placenta as a conduit for fetal infection, and demonstrate the utility of marmosets as a highly relevant model for studying congenital ZIKV disease and pregnancy loss.

Introduction Approximately 10–20% of individuals suffer from mental health concerns during the prenatal period due to their vulnerability and emotional responses to stressful events. Mental health disorders are more likely to be disabling and persistent for people of color, and they are less likely to seek treatment due to stigma. Young pregnant Black people report experiencing stress due to isolation, feelings of conflict, lack of material and emotional resources, and support from significant others. Although many studies have reported the types of stressors experienced, personal resources, emotional stress responses on pregnancy, and mental health outcomes, there is limited data on young Black women’s perceptions of these factors. Methods This study utilizes the Health Disparities Research Framework to conceptualize drivers of stress related to maternal health outcomes for young Black women. We conducted a thematic analysis to identify stressors for young Black women. Results Findings revealed the following overarching themes: Societal stress of being young, Black, and pregnant; Community level systems that perpetuate stress and structural violence; Interpersonal level stressors; Individual level effects of stress on mom and baby; and Coping with stress. Discussion Acknowledging and naming structural violence and addressing structures that create and fuel stress for young pregnant Black people are important first steps to interrogating systems that allow for nuanced power dynamics and for recognizing the full humanity of young pregnant Black people.

Postpartum hemorrhage (PPH), the leading cause of maternal mortality worldwide, is responsible for 35 percent of maternal deaths. Proximately, PPH results from the failure of the placenta to separate from the uterine wall properly, most often because of impairment of uterine muscle contraction. Despite its prevalence and its well-described clinical manifestations, the ultimate causes of PPH are not known and have not been investigated through an evolutionary lens. We argue that vulnerability to PPH stems from the intensely invasive nature of human placentation. The human placenta causes uterine vessels to undergo transformation to provide the developing fetus with a high plane of maternal resources; the degree of this transformation in humans is extensive. We argue that the particularly invasive nature of the human placenta increases the possibility of increased blood loss at parturition. We review evidence suggesting PPH and other placental disorders represent an evolutionary novel condition in hominins. La hemorragia posparto (HPP) es la principal causa de mortalidad materna en todo el mundo, responsable de 35% de las muertes maternas. Una causa de la HPP es la separación incompleta de la placenta de la pared uterina, principalmente debido a una contracción deficiente del músculo uterino. A pesar de su prevalencia, las causas exactas de la HPP no se conocen y aún no han sido investigadas usando una lente evolutiva. Sostenemos que la posibilidad para presentar HPP se debe a la naturaleza invasiva de la inserción placentaria humana. La placenta humana transforma los vasos uterinos incrementando el acceso fetal a nutrientes maternos; el grado de esta transformación en humanos es extenso. Sostenemos que la naturaleza particularmente invasiva de la placenta humana aumenta el riesgo de sangrado post partum. Finalmente, revisamos la evidencia que sugiere que la HPP y otros desórdenes placentarios representan una condición evolutiva sin precedente en humanos. Kutokwa na damu nyingi baada ya kijifungua (PPH) ni sababu kubwa ya vifo vya akina mama wakati wa uzazi duniani na ni 35% ya vifo hivyo. Kwa maelezo ya kisayansi sababu kubwa ya PPH hutokana na kondo la nyuma kushindwa kujiengua na mfuko wa uzazi, ambapo mará nyingi misuli ya mfuko huo hushindwa kubana i pasavyo. Pamoja na PPH kuwa ya kawaida na kuelezwa vizuri kitabibu, lakini tunaona sababu yake kwa msingi wa mtazamo mabadiliko ya maumbile (evolution) haijajulikana bado. Tunatoa hoja kuwa kondo la binadamu lina vyojikita na mabadiliko ya mishipa ya mfuko wa uzazi i naongeza uwezekano wa damu kutoka kwa wingi wakati wa uzazi ya kawaida kwa binadamu. Hatimaye tumepitia upya na kutafakari njia za asili za uzazi na mabadiliko ya jenetiki za kuzuia/punguza PPH.