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"Sánchez, Marta"
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One century away from home: how the red swamp crayfish took over the world
The red swamp crayfish (Procambarus clarkii) (hereafter RSC), native to the southern United States and north-eastern Mexico, is currently the most widely distributed crayfish globally as well as one of the invasive species with most devastating impacts on freshwater ecosystems. Reconstructing the introduction routes of invasive species and identifying the motivations that have led to those movements is necessary to accurately reduce the likelihood of further introductions. In this study, we: (i) review the temporal evolution of the scientific literature on the RSC; (ii) compile georeferenced, time-explicit records of the species to provide a comprehensive understanding of its global expansion process; and (iii) evaluate the potential role of biological supply companies in the translocations of the RSC. The interest of the RSC in scientific research increased steadily since the beginning of the twentieth century until stabilization in the late 1960s. The number of studies related to the use of the RSC in aquaculture showed two peaking periods: the years elapsed between 1970s to mid-1980s, and a continuous increase since the mid-1980s. Research on the RSC as an invasive species has only been numerically relevant in recent times, with the number of studies increasing since the 2000s to represent currently around 25% of the scientific production dealing with this species. Although the first introductions of the RSC took place in the 1920s, our synthesis highlights the rapid expansion of the species since the 1960s, arguably promoted by the emergence of crayfish industry, but other introduction pathways such as the mitigation of schistosomiasis, potential releases from research experiments, school science programs or pet trade cannot be ruled out. Currently, the RSC is present in 40 countries of four continents and there is still potential for further expansion. Commercial suppliers from native (Louisiana) and non-native (California or North Carolina) areas in the United States have provided live-specimens of the RSC for scientific research around the world for decades, suggesting that the invasion process of the RSC could be more complex than generally assumed. Tracing the introduction routes of invasive species and understanding the motivations that have led to those movements of species is key to reduce their spread and the likelihood of future introductions.
Journal Article
The impossible : one family's incredible true story
Based on a true story of a family caught, with tens of thousands of strangers, in the mayhem of one of the worst natural catastrophes of our time. But the true-life terror is tempered by the unexpected displays of compassion, courage, and simple kindness that Maria and her family encounter during the darkest hours of their lives.
DVD
Pharmacological Update Properties of Aloe Vera and its Major Active Constituents
Aloe vera has been traditionally used to treat skin injuries (burns, cuts, insect bites, and eczemas) and digestive problems because its anti-inflammatory, antimicrobial, and wound healing properties. Research on this medicinal plant has been aimed at validating traditional uses and deepening the mechanism of action, identifying the compounds responsible for these activities. The most investigated active compounds are aloe-emodin, aloin, aloesin, emodin, and acemannan. Likewise, new actions have been investigated for Aloe vera and its active compounds. This review provides an overview of current pharmacological studies (in vitro, in vivo, and clinical trials), written in English during the last six years (2014–2019). In particular, new pharmacological data research has shown that most studies refer to anti-cancer action, skin and digestive protective activity, and antimicrobial properties. Most recent works are in vitro and in vivo. Clinical trials have been conducted just with Aloe vera, but not with isolated compounds; therefore, it would be interesting to study the clinical effect of relevant metabolites in different human conditions and pathologies. The promising results of these studies in basic research encourage a greater number of clinical trials to test the clinical application of Aloe vera and its main compounds, particularly on bone protection, cancer, and diabetes.
Journal Article
Mitochondria-Induced Immune Response as a Trigger for Neurodegeneration: A Pathogen from Within
Symbiosis between the mitochondrion and the ancestor of the eukaryotic cell allowed cellular complexity and supported life. Mitochondria have specialized in many key functions ensuring cell homeostasis and survival. Thus, proper communication between mitochondria and cell nucleus is paramount for cellular health. However, due to their archaebacterial origin, mitochondria possess a high immunogenic potential. Indeed, mitochondria have been identified as an intracellular source of molecules that can elicit cellular responses to pathogens. Compromised mitochondrial integrity leads to release of mitochondrial content into the cytosol, which triggers an unwanted cellular immune response. Mitochondrial nucleic acids (mtDNA and mtRNA) can interact with the same cytoplasmic sensors that are specialized in recognizing genetic material from pathogens. High-energy demanding cells, such as neurons, are highly affected by deficits in mitochondrial function. Notably, mitochondrial dysfunction, neurodegeneration, and chronic inflammation are concurrent events in many severe debilitating disorders. Interestingly in this context of pathology, increasing number of studies have detected immune-activating mtDNA and mtRNA that induce an aberrant production of pro-inflammatory cytokines and interferon effectors. Thus, this review provides new insights on mitochondria-driven inflammation as a potential therapeutic target for neurodegenerative and primary mitochondrial diseases.
Journal Article
The Translational Turn
No contemporary development underscores the transnational linkage between the United States and Spanish-language América today more than the wave of in-migration from Spanish-language countries during the 1980s and 1990s. This development, among others, has made clear what has always been true, that the United States is part of Spanish-language América. Translation and oral communication from Spanish to English have been constant phenomena since before the annexation of the Mexican Southwest in 1848. The expanding number of counter-national translations from English to Spanish of Latinx fictional narratives by mainstream presses between the 1990s and 2010 is an indication of significant change in the relationship.A Translational Turnexplores both the historical reality of Spanish to English translation and the \"new\" counter-national English to Spanish translation of Latinx narratives. More than theorizing about translation, this book underscores long-standing contact, such as code-mixing and bi-multilingualism, between the two languages in U.S. language and culture. Although some political groups in this country persist in seeing and representing this country as having a single national tongue and community, the linguistic ecology of both major cities and the suburban periphery, here and in the global world, is bilingualism and multilingualism.
eBook
Immunomodulatory, Anti-Inflammatory, and Anti-Cancer Properties of Ginseng: A Pharmacological Update
Ginseng, a medicinal plant of the genus Panax, boasts a rich historical record of usage that dates back to the Paleolithic period. This botanical is extensively acknowledged and consumed in Eastern countries for its therapeutic properties, and, in Western countries, it is becoming increasingly popular as a remedy for fatigue and asthenia. This review provides an update on current research pertaining to ginseng and its isolated compounds, namely, ginsenosides and polysaccharides. The primary focus is on three crucial pharmacological activities, namely, immunomodulation, anti-inflammatory, and anti-cancer effects. The review encompasses studies on both isolated compounds and various ginseng extracts obtained from the root, leaves, and berries.
Journal Article
Pharmacological and behavioral divergence of ketamine enantiomers: implications for abuse liability
Ketamine, a racemic mixture of (S)-ketamine and (R)-ketamine enantiomers, has been used as an anesthetic, analgesic and more recently, as an antidepressant. However, ketamine has known abuse liability (the tendency of a drug to be used in non-medical situations due to its psychoactive effects), which raises concerns for its therapeutic use. (S)-ketamine was recently approved by the United States’ FDA for treatment-resistant depression. Recent studies showed that (R)-ketamine has greater efficacy than (S)-ketamine in preclinical models of depression, but its clinical antidepressant efficacy has not been established. The behavioral effects of racemic ketamine have been studied extensively in preclinical models predictive of abuse liability in humans (self-administration and conditioned place preference [CPP]). In contrast, the behavioral effects of each enantiomer in these models are unknown. We show here that in the intravenous drug self-administration model, the gold standard procedure to assess potential abuse liability of drugs in humans, rats self-administered (S)-ketamine but not (R)-ketamine. Subanesthetic, antidepressant-like doses of (S)-ketamine, but not of (R)-ketamine, induced locomotor activity (in an opioid receptor-dependent manner), induced psychomotor sensitization, induced CPP in mice, and selectively increased metabolic activity and dopamine tone in medial prefrontal cortex (mPFC) of rats. Pharmacological screening across thousands of human proteins and at biological targets known to interact with ketamine yielded divergent binding and functional enantiomer profiles, including selective mu and kappa opioid receptor activation by (S)-ketamine in mPFC. Our results demonstrate divergence in the pharmacological, functional, and behavioral effects of ketamine enantiomers, and suggest that racemic ketamine’s abuse liability in humans is primarily due to the pharmacological effects of its (S)-enantiomer.
Journal Article
Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection
Neurodegenerative diseases (NDs) affect the West due to the increase in life expectancy. Nervous cells accumulate oxidative damage, which is one of the factors that triggers and accelerates neurodegeneration. However, cells have mechanisms that scavenge reactive oxygen species (ROS) and alleviate oxidative stress (OS). Many of these endogenous antioxidant systems are regulated at the gene expression level by the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2). In the presence of prooxidant conditions, Nrf2 translocates to the nucleus and induces the transcription of genes containing ARE (antioxidant response element). In recent years, there has been an increase in the study of the Nrf2 pathway and the natural products that positively regulate it to reduce oxidative damage to the nervous system, both in in vitro models with neurons and microglia subjected to stress factors and in vivo models using mainly murine models. Quercetin, curcumin, anthocyanins, tea polyphenols, and other less studied phenolic compounds such as kaempferol, hesperetin, and icariin can also modulate Nrf2 by regulating several Nrf2 upstream activators. Another group of phytochemical compounds that upregulate this pathway are terpenoids, including monoterpenes (aucubin, catapol), diterpenes (ginkgolides), triterpenes (ginsenosides), and carotenoids (astaxanthin, lycopene). This review aims to update the knowledge on the influence of secondary metabolites of health interest on the activation of the Nrf2 pathway and their potential as treatments for NDs.
Journal Article
Bluetongue Virus in the Iberian Lynx ( Lynx pardinus ), 2010–2022
Clinical infection and death caused by bluetongue virus infection has been reported in the Eurasian lynx. Bluetongue virus surveillance in the Iberian lynx revealed widespread and repeated exposure to serotypes 1 and 4 in wild and captive populations of this species. This exposure is possibly from a spillover event from sympatric ruminants.
Journal Article