Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
998,811
result(s) for
"S. Kim"
Sort by:
Status and Performance of the AMoRE-I Experiment on Neutrinoless Double Beta Decay
AMoRE is an international project to search for the neutrinoless double beta decay of
100
Mo
using a detection technology consisting of magnetic microcalorimeters (MMCs) and molybdenum-based scintillating crystals. Data collection has begun for the current AMORE-I phase of the project, an upgrade from the previous pilot phase. AMoRE-I employs thirteen
48
depl
.
Ca
100
MoO
4
crystals and five
Li
2
100
MoO
4
crystals for a total crystal mass of 6.2 kg. Each detector module contains a scintillating crystal with two MMC channels for heat and light detection. We report the present status of the experiment and the performance of the detector modules.
Journal Article
Constellations
An illustrated introduction to constellations that explains how constellations are useful, who discovered them, and related topics.
Book
Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition
Despite remarkable progress in cutaneous melanoma genomic profiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear. Forty-six PMMs underwent targeted exome sequencing of 111 cancer-associated genes. Seventy-six somatic nonsynonymous mutations in 42 genes were observed, and recurrent mutations were noted on eight genes, including
TP53
(13%),
NRAS
(13%),
SNX31
(9%),
NF1
(9%),
KIT
(7%) and
APC
(7%). Mitogen-activated protein kinase (MAPK; 37%), cell cycle (20%) and phosphatidylinositol 3-kinase (PI3K)-mTOR (15%) pathways were frequently mutated. We biologically characterized a novel
ZNF767-BRAF
fusion found in a vemurafenib-refractory respiratory tract PMM, from which cell line harboring
ZNF767-BRAF
fusion were established for further molecular analyses. In an independent data set,
NFIC-BRAF
fusion was identified in an oral PMM case and
TMEM178B-BRAF
fusion and
DGKI-BRAF
fusion were identified in two malignant melanomas with a low mutational burden (number of mutation per megabase, 0.8 and 4, respectively). Subsequent analyses revealed that the ZNF767-BRAF fusion protein promotes RAF dimerization and activation of the MAPK pathway. We next tested the
in vitro
and
in vivo
efficacy of vemurafenib, trametinib, BKM120 or LEE011 alone and in combination. Trametinib effectively inhibited tumor cell growth
in vitro
, but the combination of trametinib and BKM120 or LEE011 yielded more than additive anti-tumor effects both
in vitro
and
in vivo
in a melanoma cells harboring the
BRAF
fusion. In conclusion,
BRAF
fusions define a new molecular subset of PMM that can be targeted therapeutically by the combination of a MEK inhibitor with PI3K or cyclin-dependent kinase 4/6 inhibitors.
Journal Article
Exploring coherent elastic neutrino-nucleus scattering using reactor electron antineutrinos in the NEON experiment
Neutrino elastic scattering observation with NaI (NEON) is an experiment designed to detect neutrino-nucleus coherent scattering using reactor electron antineutrinos. NEON is based on an array of six NaI(Tl) crystals with a total mass of 13.3 kg, located at the tendon gallery that is 23.7 m away from a reactor core with a thermal power of 2.8 GW in the Hanbit nuclear power complex. The installation of the NEON detector was completed in December 2020, and since May 2021, the detector has acquired data at full reactor power. Based on the observed light yields of the NaI crystals of approximately 22, number of photoelectrons per unit keV electron-equivalent energy (keVee), and 6 counts/kg/keV/day background level at 2–6 keVee energy, coherent elastic neutrino-nucleus scattering (CE
ν
NS) observation sensitivity is evaluated as more than 3
σ
assuming 1-year reactor-on and 100 days reactor-off data, 0.2 keVee energy threshold, and 7 counts/keV/kg/day background in the signal region of 0.2
-
0.5 keVee. This paper describes the design of the NEON detector, including the shielding arrangement, configuration of NaI(Tl) crystals, and associated operating systems. The initial performance and associated sensitivity of the experiment are also presented.
Journal Article
Charge-ordering cascade with spin–orbit Mott dimer states in metallic iridium ditelluride
Spin–orbit coupling results in technologically-crucial phenomena underlying magnetic devices like magnetic memories and energy-efficient motors. In heavy element materials, the strength of spin–orbit coupling becomes large to affect the overall electronic nature and induces novel states such as topological insulators and spin–orbit-integrated Mott states. Here we report an unprecedented charge-ordering cascade in IrTe
2
without the loss of metallicity, which involves localized spin–orbit Mott states with diamagnetic Ir
4+
–Ir
4+
dimers. The cascade in cooling, uncompensated in heating, consists of first order-type consecutive transitions from a pure Ir
3+
phase to Ir
3+
–Ir
4+
charge-ordered phases, which originate from Ir 5
d
to Te 5
p
charge transfer involving anionic polymeric bond breaking. Considering that the system exhibits superconductivity with suppression of the charge order by doping, analogously to cuprates, these results provide a new electronic paradigm of localized charge-ordered states interacting with itinerant electrons through large spin–orbit coupling.
The influence of spin–orbit coupling on itinerant electrons underlies the formation of spin–orbit Mott states. Here, the authors demonstrate a temperature-hysteretic cascade between charge-ordered phases stabilized by localized 5
d
spin–orbit Mott dimer states in metallic iridium ditelluride.
Journal Article
Competing values leadership
\"This book serves as the key source for understanding the Competing Values Framework, one of the most widely used and highly cited frameworks in the world. The authors, who have been at the foundation of developing, applying and studying this framework for over three decades, explain how it helps foster successful leadership, improve organizational effectiveness and promote value creation.\"-- Publisher's description.
Book
Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial
Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. We aimed to compare survival outcomes of laparoscopic surgery with open surgery for patients with mid-rectal or low-rectal cancer.
The Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial was an open-label, non-inferiority, randomised controlled trial done between April 4, 2006, and Aug 26, 2009, at three centres in Korea. Patients (aged 18–80 years) with cT3N0–2M0 mid-rectal or low-rectal cancer who had received preoperative chemoradiotherapy were randomly assigned (1:1) to receive either open or laparoscopic surgery. Randomisation was stratified by sex and preoperative chemotherapy regimen. Investigators were masked to the randomisation sequence; patients and clinicians were not masked to the treatment assignments. The primary endpoint was 3 year disease-free survival, with a non-inferiority margin of 15%. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00470951.
We randomly assigned 340 patients to receive either open surgery (n=170) or laparoscopic surgery (n=170). 3 year disease-free survival was 72·5% (95% CI 65·0–78·6) for the open surgery group and 79·2% (72·3–84·6) for the laparoscopic surgery group, with a difference that was lower than the prespecified non-inferiority margin (–6·7%, 95% CI −15·8 to 2·4; p<0·0001). 25 (15%) patients died in the open group and 20 (12%) died in the laparoscopic group. No deaths were treatment related.
Our results show that laparoscopic resection for locally advanced rectal cancer after preoperative chemoradiotherapy provides similar outcomes for disease-free survival as open resection, thus justifying its use.
National Cancer Center, South Korea.
Journal Article