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Objective: To understand the cardioprotective effect of Moringa oleifera (MO) seed powder using isoproterenol induced cardiotoxicity in albino rats of wistar strain. Materials and Methods: Hydroalcoholic extract of MO (HAMO) seeds was prepared by soxhlet method and used for the study. After phytochemical analysis, the extract was evaluated for in vivo study. Six rats were grouped. Group 1 as vehicle, group 2 as disease control, group 3 as standard, group 4 and 5 as low and high dose of hydroalcoholic extract of MO (200mg/kg, 400mg/kg) respectively. ECG parameters, cardiac markers and oxidative stress were assessed. Results: 4% yield was obtained. ST segment elevation and increased heart rate by Isoproterenol was treated by hydroalcoholic extract of MO seeds. CK-MB, LDH levels were also restored in treatment groups as compared to disease control. The endogenous antioxidant enzymes catalase and GSH activity increased in treatment groups whereas lipid peroxidation was decreased significantly. The HAMO (400mg/kg) showed better cardioprotective activity as equivalent to Terminalia arjuna tablets which was used as standard. In histology findings, HAMO (400mg/kg) showed decrease in necrosis as compared to disease control. Conclusion: The HAMO (400mg/kg) has proven to attenuate cardiotoxicity induced by Isoproterenol, confirmed by ECG, cardiac markers and histopathological findings.

The energy loss of relativistic electrons in ferroelectric polymer polyvinlydineflouride (PVDF) thin film was measured at different temperatures of the film using magnetic spectrometer. Race track microtron accelerator was used to get monochromatic electron beam of energy 5.980 ± 0.02 MeV with energy resolution of 5.61%. The temperature of the film was controlled by constant current source and measured with an accuracy of ± 0.25 °C. The energy loss of 5.980 MeV electrons in ferroelectric PVDF shows a broad dip near the phase transition and then increases by ~ 35% in the paraelectric state. The paper describes the possible mechanisms to the observed change in energy loss of relativistic electrons in PVDF medium in terms of (i) ferroelectric dipole switching due to the transverse electric field and (ii) pining and depinning of the dipoles due to rise in localized lattice temperature as the electrons propagate through PVDF sample.

This study presents the hybrid direct torque control (HDTC) method for medium voltage-range induction motor (IM) drive. The control method comprising the torque control by rotor-reference frame quadrature-axis current instead-of conventional DTC and speed control similar as in space-vector-modulation (SVM)-DTC is proposed. Hence the scheme is referred as HDTC. A carrier-based space-vector-modulation controlled five-level diode-clamped multilevel inverter with proposed control scheme is providing promising-step towards performance enhancement of IM drive in respect of torque ripple contents and steady-state performance over wide speed-range. The effectiveness of the proposed control scheme is confirmed by comparison with DTC in matlab-simulink. A prototype is fabricated for three-phase, 3-HP IM. A 32-bit fixed-point DSP-based control algorithm is developed for DTC and the proposed control scheme. Experimental results show qualitative improvement in performance in terms of reduction in torque ripple by 30%, fast dynamic response even at low speed and improvement in steady state characteristics.

Milk-processing industry effluent (MPIE) poses severe problems for aquatic and environmental systems, especially in the South Asian region. Therefore, its treatment is of great interest. This study deals with the investigation of chitosan titanium dioxide nanoadsorbent (CTiO 2 ) coated onto sand particles via calcination that are used to remove the emerging pollutants. The adsorptive properties of these developed adsorbents are compared with those of the nascent sand without coating as well as with the chitosan titanium dioxide nanoadsorbent coated sand (CTiO 2 -CS). Batch adsorption experiments were performed to investigate the percent reduction efficiency (%RE) of organic pollutants in terms of biological oxygen demand (BOD) and chemical oxygen demand (COD) from synthetic and real effluents. The maximum %RE of BOD (96.76) and COD (98.91) was achieved at 1.5 M dose of CTiO 2 -CS, 120 min of contact time, pH 6.5, an initial BOD concentration of 900 mg/L, and an agitation speed of 400 rpm. Similarly, the %RE of COD was found to be 86.75 for synthetic effluent and 90.97 for real effluent at initial COD concentrations of 8000 mg/L. Pseudo-second-order and Langmuir models are found to be the best fits for BOD and COD adsorption. The diffusion model suggests that surface adsorption as well as intraparticle diffusion contribute to the actual adsorption process. Regeneration experiments were performed for four cycles, and CTiO 2 -CS was found to be the most regenerable adsorbent material. The performance of the adsorbent was compared with previous studies, and it was found to have excellent adsorption capacity. As a result, the developed filter bed could be used as a promising superadsorbent for the removal of organic load in MPIE.

Nanocrystals of the poorly water soluble drugs is a promising strategy. To stabilize the drug nanocrystals, stabilizers are usually used; however, the use of common stabilizers is limited by weak stabilization effect and toxicological concerns for long-term treatment. The present work was aimed to investigate the potential of natural silk protein as novel stabilizer for nanocrystal of hydrochlorothiazide, which was a model drug. The nanocrystals of drug with hydrophobic protein stabilizer were prepared by antisolvent precipitation method. Prepared nanocrystals were evaluated for parameters like particle size, zeta potential, DSC, XRD, %crystallinity, SEM, drug content and in vitro dissolution test. Stabilization efficiency of nanocrystals was assessed by their % crystallinity for 3 months. Optimized batch R2 was shown smaller particle size, highest drug content and drug dissolution. Nanocrystals were shown the extended release due to coat of fibroin around the hydrochlorothiazide. From the % crystallinity study it was found that there was not significant change in the nanocrystals prepared using fibroin. So, it was concluded that the fibroin is good stabilizer for drug nanocrystals.

Wind speed modelling is very crucial in estimating the potential of wind energy for a particular site. In this paper, the wind energy potential at the premises of Government Science College area [Lat. 14°13’′ N and Long. 76°27′ E] in Chitradurga town (Karnataka State, India) is statistically analyzed for the year 2019 – 2020. The speed of wind has been assessed at the height of 60 m from the ground level at the site. The seasonal and annual wind speed distributions (WSD) have been modelled using Weibull probability distribution functions (WPDF) i.e., shape parameter, k and scale parameters, c . With the use of them, the wind power density (WPD) has been determined. The WPD estimated from Weibull and normal methods has been found to be comparable. Further, at a height of 60 m above the ground, the capacity factors (CPs) of various marketablly useable wind turbine generators have been estimated to achieve the optimal power generation for the chosen site.

Materials and Methods: This was a prospective interventional study conducted to assess the clinical efficacy and safety of 0.2% olopatadine hydrochloride ophthalmic solution on 49 pediatric allergic conjunctivitis patients. 1-2 drops of the ophthalmic solution were administered once daily in each eye for 6 weeks. [4] Degranulation of conjunctival mast cells has a major role in ocular allergic disease, and thus, treatment should be concentrated on preventing it and also block histaminergic effects as histamine plays a primary mediator. [5] Diagnosis is generally made through history and careful clinical observation. Since the presence of an antigen initiates the allergic cascade, avoidance of allergic antigen is the most important for all types of allergic diseases. The pharmacologic agents that are available as ophthalmic solutions, used in the treatment of allergic conjunctivitis belong to diverse classes: (1) Antihistamines - which block H1 receptors, e.g., levocabastine, azelastine, emedastine, bepotastine, and alcaftadine; (2) Mast cell stabilizers - which increase the calcium influx to the mast cell and prevent changes in the membrane permeability resulting in the stability of membrane decreasing degranulation of mast cells,[6] e.g. sodium cromoglycate, nedocromil sodium, pemirolast, and lodoxamide; (3) Dual acting agents - they have both antihistaminic and mast cell stabilizing properties, e.g., olopatadine, ketotifen, azelastine, and epinastine; (4) Non-steroidal anti-inflammatory drugs, e.g., ketorolac, diclofenac, and flurbiprofen; (5) Corticosteroids, e.g., prednisolone, hydrocortisone, fluorometholone, loteprednol, and desonide. MATERIALS AND METHODS Study Design This study was a prospective interventional study conducted in the Ophthalmic outpatient department, Father Muller Medical College Hospital, Mangalore,...