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A total of 4752 patients were randomly assigned to CABG with (on-pump) or without (off-pump) cardiopulmonary bypass. At 1 year, there was no significant difference in neurocognitive function or quality of life or in the composite of death, MI, stroke, or renal failure. Coronary-artery bypass grafting (CABG) reduces mortality among patients with extensive coronary artery disease. 1 CABG is usually performed with the use of cardiopulmonary bypass (on-pump CABG). With this approach, perioperative mortality is about 2%, and myocardial infarction, stroke, or renal failure requiring dialysis develop in an additional 5 to 7% of patients. The technique of performing CABG on a beating heart (off-pump CABG) was developed to reduce perioperative complications, some of which may be related to the use of cardiopulmonary bypass and to the cross-clamping of the aorta associated with the on-pump CABG procedure, and to improve long-term outcomes. A number . . .

There has been little attention paid to the management of corporate brand names as part of the merger and acquisition process. As an initial step towards developing a better understanding of this brand redeployment decision the authors consider the reactions of one important stakeholder group-consumers-to alternative strategies. Specifically, the authors discuss the importance of the corporate branding decision in the M&A process and present a typology of alternative redeployment strategies as well as an exploratory study examining reactions to different postmerger branding strategies. The authors find evidence that the brand equity related to corporate brands is often decreased as a result of M&A activities and that individuals react differently to mergers employing different redeployment strategies. These results emphasize the need for firms to evaluate the corporate branding component of M&A activities as part of the process of managing corporate brands and should generate interest and research in this managerially relevant area. [PUBLICATION ABSTRACT]

This article focuses on the impact of a new brand extension introduction on choice in a behavioral context using national household scanner data involving multiple brand extensions. Particularly, the authors investigate the reciprocal impact of trial of successful and unsuccessful brand extensions on parent brand choice. In addition, the authors examine the effects of experience with the parent brand on consumers' trial and repeat of a brand extension using household scanner data on six brand extensions from a national panel. In the case of successful brand extensions, the results show positive reciprocal effects of extension trial on parent brand choice, particularly among prior non-users of the parent brand, and consequently on market share. The authors find evidence for potential negative reciprocal effects of unsuccessful extensions. In addition, the study shows that experience with the parent brand has a significant impact on extension trial, but not on extension repeat.

Ethanol consumption and cigarette smoking are common in societies worldwide and have been identified as injurious to human health. This study was undertaken to examine the interactive effects of chronic ethanol and nicotine consumption on the antioxidant defense system in different tissues of rat. Male Fisher-344 rats were divided into four groups of five animals each and treated for 6.5 weeks as follows: (1) Control rats were administered normal saline orally; (2) ethanol (20% [wt./vol.]) was given orally at a dose of 2 g/kg; (3) nicotine was administered subcutaneously at a dose of 0.1 mg/kg; and (4) a combination of ethanol plus nicotine was administered by the route and at the dose described above. The animals were killed 20 h after the last treatment, and liver, lung, kidney, and testes were isolated and analyzed. Chronic ingestion of ethanol resulted in a significant depletion of glutathione (GSH) content in liver, lung, and testes, whereas chronic administration of nicotine significantly depleted GSH content in liver and testes. The combination of ethanol plus nicotine resulted in a significant depletion of GSH content in liver, lung, and testes. Ethanol, nicotine, or a combination of ethanol plus nicotine significantly increased superoxide dismutase (SOD) activity in liver and decreased SOD activity in kidney. Ethanol, nicotine, or a combination of ethanol plus nicotine significantly decreased catalase (CAT) activity in liver and increased CAT activity in kidney and testes. Chronic ingestion of ethanol resulted in a significant decrease in glutathione peroxidase (GSH-Px) activity in liver and kidney, whereas a combination of ethanol plus nicotine increased GSH-Px activity in liver and decreased GSH-Px activity in kidney and testes. Ethanol, nicotine, or a combination of ethanol plus nicotine significantly increased lipid peroxidation, respectively, in liver. It is suggested that prolonged exposure to ethanol and nicotine produce similar, and in some cases additive, oxidative tissue injuries in rat.

Black, K.P.; Reddy, K.S.K.; Kulkarni, K.B.; Naik, G.B.; Shreekantha, P., and Mathew, J., 2020. Salient evolution and coastal protection effectiveness of two large artificial reefs. Journal of Coastal Research, 36(4), 709–719. Coconut Creek (Florida), ISSN 0749-0208. Two offshore reefs constructed at Ullal, Karnataka, on India's west coast, are exhibiting coastal protection benefits. The reefs are large (275 m and 325 m long) and uniquely placed well offshore (600 m and 760 m) in intermediate depths (6 and 7 m below chart datum). Their crests are between low-tide and midtide level. Bathymetric and beach surveys show that sand has accumulated to form two evolving shoreline salients, which are currently 2–3 times the length of the reefs. The salients have grown underwater on the inner shelf to create a large sand-retention zone up to 1 m thick and stretching from the beach to the distant lee of the reefs. The reefs are the first protection structures that have restored the beaches and enhanced sand storage over this broad, severely eroded region, both inshore and on the inner shelf. Prior rubble-mound rock revetments (seawalls) and 50–70-m-long groynes failed to restore the beach in stormy monsoon conditions, while the inner shelf continued to erode. The reefs were designed using a combination of computer simulations, measurements of natural salients in India, and empirical relationships. The methodology that led to the reef shapes/sizes and their position offshore is discussed, along with monitoring results.

{Figure 3}{Figure 4}{Figure 5}{Figure 6}{Figure 7} The term \"Sister Mary Joseph Nodule\" is used to describe a metastatic umbilical nodule usually associated with advanced intra-abdominal cancer and its presence indicates a poor prognosis. [4] In the present case the primary was found to be borderline mucinous cystadenocarcinoma with mature teratoma which is quite unique. [...]in this case the ovarian malignancy was associated with pseudomyxoma peritonei which is a relatively rare condition (1 case/million per year).

OBJECTIVE: Urgent colonoscopy is often recommended to evaluate acute rectal bleeding. However, it may not identify a source because of blood in the lumen or inadequate preparation. Our aim was to determine the utility of urgent colonoscopy as the initial test for acute rectal bleeding. METHODS: This was a retrospective chart review of all patients discharged in 1997 and 1998 with an International Classification of Diseases, 9th Revision, code for hematochezia or rectal bleeding. RESULTS: We identified 514 charts but excluded 424 because of inaccurate coding. In the 90 with confirmed acute rectal bleeding, colonoscopy was the initial test in 39; age, sex, and race distributions were similar to those who did not have colonoscopy. A definite source of bleeding was seen at colonoscopy in only three patients, a probable source in 26, and no source in 10. Therapeutic intervention in four patients with a definite or probable source was successful in three. The commonest reasons for not performing urgent colonoscopy were bleeding from presumed hemorrhoids or bleeding that was clinically insignificant. Spontaneous resolution of bleeding and length of hospital stay were not affected by urgent colonoscopy. Five patients had surgery for unrelated reasons. In-hospital mortality was 2% and was unrelated to bleeding. CONCLUSION: Urgent colonoscopy as the initial investigation in acute lower GI tract bleeding probably does not alter the outcome in most cases. Identification of a definite bleeding source leading to successful therapeutic intervention is rare. Spontaneous resolution is frequent, length of hospital stay is similar, and clinical outcome is excellent regardless of whether or not urgent colonoscopy is performed.

Revisiting and updating the definition and classification of cerebral palsy (CP) is not just an academic task for the developmental paediatrician and neurologist but an exercise aimed at providing a framework for multidisciplinary management by all professionals and care providers involved in the care of children with developmental disabilities.

Advertisers have many numbers of medium for their promotional activities but the importance of medium depends upon the target customers, types of goods/services, 5M's of advertising and many other factors. In this article, the authors discuss about mobile phones as the latest tools for brand promotion. Mobile advertising grows bigger than any other form of digital or Internet advertising. The number of customers who use mobiles have been rapidly increasing around the world. Response rate of audiences is also high on mobile as compared to other tools of advertising. And, there are more chances of seeing an ad in the mobile using SMS, MMS or WAP applications. This article attempts to find out the impact of mobile advertising in the mind of customers, especially in metropolital city like Delhi, India. Further, it also tries to find out the good and the bad effects on product/services due to mobile advertising.