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The thirst
In Police, the last novel featuring Jo Nesbo's hard-bitten, maverick Oslo detective, a killer wreaking revenge on the police had Harry Hole fighting for the safety of the people closest to him. Now, in The Thirst, the story continues as Harry is inextricably drawn back into the Oslo police force. A serial murderer has begun targeting Tinder daters -- a murderer whose MO reignites Harry's hunt for a nemesis of his past.
Book
Applied regression analysis
An outstanding introduction to the fundamentals of regression analysis-updated and expanded The methods of regression analysis are the most widely used statistical tools for discovering the relationships among variables. This classic text, with its emphasis on clear, thorough presentation of concepts and applications, offers a complete, easily accessible introduction to the fundamentals of regression analysis. Assuming only a basic knowledge of elementary statistics, Applied Regression Analysis, Third Edition focuses on the fitting and checking of both linear and nonlinear regression models, using small and large data sets, with pocket calculators or computers. This Third Edition features separate chapters on multicollinearity, generalized linear models, mixture ingredients, geometry of regression, robust regression, and resampling procedures. Extensive support materials include sets of carefully designed exercises with full or partial solutions and a series of true/false questions with answers. All data sets used in both the text and the exercises can be found on the companion disk at the back of the book. For analysts, researchers, and students in university, industrial, and government courses on regression, this text is an excellent introduction to the subject and an efficient means of learning how to use a valuable analytical tool. It will also prove an invaluable reference resource for applied scientists and statisticians.
eBook
The carbon dioxide removal gap
Rapid emissions reductions, including reductions in deforestation-based land emissions, are the dominant source of global climate mitigation potential in the coming decades. However, carbon dioxide removal (CDR) will also have an important role to play. Despite this, it remains unclear whether current national proposals for CDR align with temperature targets. Here we show the ‘CDR gap’, that is, CDR efforts proposed by countries fall short of those in integrated assessment model scenarios that limit warming to 1.5 °C. However, the most ambitious proposals for CDR are close to levels in a low-energy demand scenario with the most-limited CDR scaling and aggressive near-term emissions reductions. Further, we observe that many countries propose to expand land-based removals, but none yet commit to substantively scaling novel methods such as bioenergy carbon capture and storage, biochar or direct air carbon capture and storage.
Carbon dioxide removals (CDR) have been integrated into country-submitted reports under the Paris Agreement. However, this Analysis finds a gap between levels of CDR in these national proposals and the scenarios limiting global warming to the 1.5 °C target.
Publication
Long-term national climate strategies bet on forests and soils to reach net-zero
The deployment of carbon dioxide removal is essential to reach global and national net-zero emissions targets, but little attention has been paid to its practical deployment by countries. Here, we analyse how carbon dioxide removal methods are integrated into 41 of the 50 Long-term Low Emission Development Strategies submitted to the United Nations Framework Convention on Climate Change (UNFCCC), before 2022. We show that enhancing forest and soil carbon sinks are the most advocated strategies but are only explicitly quantified in 12. Residual emissions by 2050 are only quantified in 20 strategies and most of them use forests to achieve national net-zero targets. Strategies that quantify both residual emissions and carbon dioxide removal identify national constraints, such as wildfire risks to forests and limited geological CO 2 storage capacity. These strategies also highlight the need for international cooperation. Taken together, we suggest that the UNFCCC should urgently strengthen its reporting requirements on long-term national climate strategies.
Journal Article
Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is associated with adverse health outcomes in children. We hypothesized that DNA methylation changes may result from prenatal PFAS exposure and may be linked to offspring cardio-metabolic phenotype.
We estimated associations of prenatal PFAS with DNA methylation in umbilical cord blood. We evaluated associations of methylation at selected sites with neonatal cardio-metabolic indicators.
Among 583 mother-infant pairs in a prospective cohort, five PFAS were quantified in maternal serum (median 27 wk of gestation). Umbilical cord blood DNA methylation was evaluated using the Illumina HumanMethylation450 array. Differentially methylated positions (DMPs) were evaluated at a false discovery rate
and differentially methylated regions (DMRs) were identified using comb-p (Šidák-adjusted
). We estimated associations between methylation at candidate DMPs and DMR sites and the following outcomes: newborn weight, adiposity, and cord blood glucose, insulin, lipids, and leptin.
Maternal serum PFAS concentrations were below the median for females in the U.S. general population. Moderate to high pairwise correlations were observed between PFAS concentrations (
). Methylation at one DMP (cg18587484), annotated to the gene
, was associated with perfluorooctanoate (PFOA) at
. Comb-p detected between 4 and 15 DMRs for each PFAS. Associated genes, some common across multiple PFAS, were implicated in growth (
), lipid homeostasis (
,
,
,
), inflammation and immune activity (
,
), among other functions. There was suggestive evidence that two PFAS-associated loci (cg09093485, cg09637273) were associated with cord blood triglycerides and birth weight, respectively (
).
DNA methylation in umbilical cord blood was associated with maternal serum PFAS concentrations during pregnancy, suggesting potential associations with offspring growth, metabolism, and immune function. Future research should explore whether DNA methylation changes mediate associations between prenatal PFAS exposures and child health outcomes. https://doi.org/10.1289/EHP6888.
Journal Article
Phytochromes and light signal perception by plants—an emerging synthesis
For plants, the sensing of light in the environment is as important as vision is for animals. Fluctuations in light can be crucial to competition and survival. One way plants sense light is through the phytochromes, a small family of diverse photochromic protein photoreceptors whose origins have been traced to the photosynthetic prokaryotes. During their evolution, the phytochromes have acquired sophisticated mechanisms to monitor light. Recent advances in understanding the molecular mechanisms of phytochromes and their significance to evolutionary biology make possible an interim synthesis of this rapidly advancing branch of photobiology.
Journal Article