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We simulated a tropical cyclone in an idealized environment, from its weak initial vortex to maturity, using a regional numerical weather prediction model with a uniform horizontal resolution of 100 m, regarded as a large eddy simulation (LES). Results of the LES were compared with those of the same model, but with a horizontal resolution of 2 km. Both experiments attained similar peak intensities (∼920 ${\\sim} 920$ hPa), but the LES uniquely captured kilometer‐scale rolls in the boundary layer, persistent shallow mesovortices near the eyewall, and countless sub‐kilometer‐scale patches of positive and negative vorticity. Rapid intensification (RI) in the LES was delayed by approximately 26 hr relative to that in the 2 km model. Composite analysis confirmed that mesovortices interfered with the azimuthally averaged secondary circulation. The prevalence of negative vorticity and decelerated inflow in the LES are likely to delay the RI.

Most upcoming CMB experiments are planning to deploy between a few thousand and a few hundred thousand TES bolometers in order to drastically increase sensitivity and unveil the B -mode signal. Differential systematic effects and 1/ f noise are two of the challenges that need to be overcome in order to achieve this result. In recent years, rotating half-wave plates have become increasingly more popular as a solution to mitigate these effects, especially for those experiments that are targeting the largest angular scales. However, other effects may appear when a rotating HWP is being employed. In this paper, we focus on HWP synchronous signals, which are due to intensity to polarization leakage induced by a rotating cryogenic multilayer sapphire HWP employed as the first optical element of the telescope system. We use LiteBIRD LFT as a case study and we analyze the interaction between these spurious signals and TES bolometers, to determine whether this signal can contaminate the bolometer response. We present the results of simulations for a few different TES model assumptions and different spurious signal amplitudes. Modeling these effects is fundamental to find what leakage level can be tolerated and minimize nonlinearity effects of the bolometer response.

We have previously shown that tumor necrosis factor (TNF)α produced from primary tumor-induced expression of two endogenous Toll-like receptor 4 (TLR4) ligands, S100A8 and serum amyloid A3 (SAA3), in pre-metastatic lungs. However, mechanistic details of the signaling network and relevance to pulmonary physiology are poorly understood. Here, we identify Clara cells as a control tower of the network. Clara cell ablation by naphthalene suppressed pulmonary recruitment of CD11b+TLR4+ cells and spontaneous lung metastasis. Clara cells turned out to express TLR4 through which SAA3 was auto-amplified. Reciprocal bone marrow transplantation between wild-type and TLR4 knockout mice demonstrated that pulmonary TLR4+ Clara cells could be derived from bone marrow. SAA3-induced TNFα expression in both alveolar type II cells and macrophages. Primary co-cultures of alveolar type II cells and Clara cells revealed that the induction of TNFα in alveolar type II cells was dependent on the Clara cell-mediated amplification of SAA3. SAA3 induction by bacterial endotoxin also required both Clara cells and TLR4. Thus, pulmonary metastatic soil may feature deregulation of homeostatic inflammatory responses to constant assaults of microbes with endotoxin.

We laser-ablated sub-wavelength structures (SWS) on 200 mm diameter birefringent sapphire disks to produce broadband anti-reflection coating (ARC). The disks were assembled into a stack of five plates making an achromatic half-wave plate (AHWP) suitable for operation between 40 and 140 GHz. We report on the SWS fabrication and transmission measurements of the stack at room temperature. From the measurements, we compute a band average transmission and modulation efficiency for nine spectral bands that correspond to the frequency coverage of the LiteBIRD Low-Frequency Telescope (LFT). We also assess the level of instrumental polarization the AHWP exhibits. We discuss paths for further development to minimize the instrumental polarization from the AHWP. This work is a development milestone toward the implementation of an AHWP for the LiteBIRD satellite.

We measured the vibration of a prototype superconducting magnetic bearing (SMB) operating at liquid nitrogen temperature. This prototype system was designed as a breadboard model for LiteBIRD low-frequency telescope (LFT) polarization modulator unit. We set an upper limit of the vibration amplitude at 36  μ m at the rotational synchronous frequency. During the rotation, the amplitude of the magnetic field produced varies. From this setup, we compute the static and AC amplitude of the magnetic fields produced by the SMB magnet at the location of the LFT focal plane as 0.24 and 3 × 10 - 5  G, respectively. From the AC amplitude, we compute TES critical temperature variation of 7 × 10 - 8  K and fractional change of the SQUID flux is δ Φ / Φ 0 | ac = 3.1 × 10 - 5 . The mechanical vibration can be also estimated to be 3.6 × 10 - 2  N at the rotation mechanism location.

Abstract Introduction Japanese medical students spend their school days under a dense curriculum. It is often difficult to maintain their healthy lifestyle. After graduation, most of them participate in clinical training programs as residents. It is also difficult to maintain a normal life because they are engaged in different specialized departments every few months. Such an environment is considered prone to mental health problems. In fact, one in four residents are reported to be newly depressed two months after the start of clinical training (Maeno T, et al. 2008). These mental health issues are thought to be affected by changes in daily life, but it is difficult to know such changes. In order to investigate changes in their daily lives, we developed a data collection system related to mental health via the Internet. Methods The subjects were 22 medical students who graduated from our university in March 2017. They were asked to wear activity tracker wrist bands from December 2016. They were also asked to answer the questionnaire on a web site every week as much as possible, and the responses were collected via the Internet together with the activity data. The first eight months of the observation period, including four months before the start of clinical training and four month after the start of clinical training, are divided into four quarters every two months, and the averaged sleep time and responses to the questionnaire in each period were investigated. Results The average number of days that the sleep was effectively recorded during each two months was 28–48. The average number of responses to the questionnaire during each two months was 6.0–7.2. Conclusion Residents in the initial clinical training period should be very busy, but the system we have developed seems to have worked well with them for the first four months after the start of clinical training. Whether this system would work as well a longer period is a further problem. Support This study is supported by KAKENHI 16K01753.

Using powerful jet propulsion, some squid species are able to exit the water and become airborne; this is a common behavior seen throughout the world’s oceans. However, direct scientific observation is rare, with most studies relying on anecdotal evidence and limited photographic documentation. Here, we examine the flying behavior of young oceanic squid (Ommastrephidae) observed in sequential photographs taken in the Northwest Pacific (35 o 34.0′N, 146 o 19.3′E) on July 25, 2011. We define four phases in the flight process: launching, jetting, gliding and diving. During flight, squid actively change their aerial posture and attitude depending on the flight phase and their distance from the water. The present study demonstrated that flight of squid is not simple gliding after incidental exit from the water, but involves jet propulsion, generation of lift force and control of different body postures in different flight phases, which have evolved to enhance escape from predators.

The polarization modulator of LiteBIRD satellite is required to be used by continuously rotating the half-wave retarder under a low temperature environment of about 10 K. Then, it becomes an important issue to reduce heat generation due to rotation loss. Therefore, a rotation mechanism in a cryogenic environment by a superconducting magnetic bearing (SMB) using the pinning effect of the bulk superconductor has been studied. In SMB, because of the pinning effect of superconductor, it is possible to rotate the half-wave retarder with stably floating, and it is possible to avoid frictional heat due to contact. The half-wave retarder is incorporated inside the rotating part of the superconducting magnetic bearing composed of the permanent magnet ring and the iron yoke. At this time, since the permanent magnet ring divides the parallel magnetized permanent magnets into pieces, a gap is formed at the joint of the permanent magnets. For this reason, the magnetic field distribution generated by the permanent magnet ring is not uniform. Although SMB can reduce friction as compared to mechanical bearings, the magnetic properties of the bulk superconductor change due to the magnetic field fluctuation caused by such ununiformity of the magnetic field, resulting in energy loss. In this study, heat generation in bulk superconductor in SMB is evaluated by three-dimensional finite element method. First, using JMAG Designer 17.0, the magnetic field distribution created by the rotor side is obtained by static magnetic field analysis. Next, using the COMSOL Multiphysics 5.3a, by applying the magnetic field distribution created by the rotor side obtained above and rotate the magnetic field, the loss generated in the bulk superconductor is investigated. The resulting loss value satisfied the required value.

A database containing spectrum and cross-section of the fluorescence of substances has been made. In test of forest environment monitoring by our Laser-Induced Fluorescence Spectrum (LIFS) lidar, the database showed that the origin substance of the aerosol observed by the lidar was cedar pollen, and the concentration was calculated using the cross-section. In the urban atmosphere monitoring, three substances stored in the database were proposed to be the origins of the aerosol. Based on these experiments, we discuss the usefulness of the fluorescence database in lidar observations.

This paper describes the losses of the rotor of the prototype superconducting magnetic bearing (SMB) that is employed for a polarization modulator of a Cosmic Microwave Background polarization experiment. The stator is composed of 20 segmented YBCO bulks, and these multiple superconductors produce the inhomogeneous magnetic field particularly due to the gravitational displacement of the rotor magnet position from the initial field cooling. This inhomogeneity causes the power dissipation to the spinning rotor. We estimated the power dissipation originating from this inhomogeneous magnetic field by using a numerical approach. The superconductors were modelled as electrically conducting components in the numerical simulation to avoid the complexity in modelling superconductivity. The results show about 4 mW dissipated at the rotor.