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This paper summarizes the 76th LCA Discussion Forum end its main findings. Main issues when addressing emerging technologies identified were: the lack of primary data, the need for (shared) future background scenarios and (guidlines for) a common methodology. The following recommendations have been derived by the organizers: 1) Specific foreground inventories are always tailor-made, but consistency can be improved through lists of mandatory considerations. 2) Continue sharing (future) technology data and proxy processes, that can be readily replicated to new studies and assist in developing inventories. 3) Streamline and unify the process of including scenarios for background systems. New approaches may provide first important solutions to efficiently include consistent future scenarios in prospective LCA.

Microplastics are ubiquitous in ecosystems and a lot of research is being performed to understand their environmental fate and effects on organisms. However, the release and impact of MP has so far not been considered in LCA studies. This is due to missing information on the inventory side about microplastic releases and missing Characterization Factors to quantify the effects of MP. The goal of this study was to elucidate the relevance of MP release into freshwaters from an LCA perspective, by using worst-case assumptions. In accordance with the USEtox framework, an interim and simplified Characterization Factor for the impact category of freshwater ecotoxicity was calculated to be 3231 PAF·m3·d·kg−1. Applying this Characterization Factor, two LCA case studies were conducted, one on a polyester T-Shirt and one with a shower gel containing microplastics. The results show a small contribution of microplastics to the freshwater ecotoxicity for a scenario with state-of-the-art wastewater treatment. Different scenarios varying in microplastic release and removal during wastewater treatment and a sensitivity analysis of the Characterization Factor allowed identifying the potential range of the microplastic contribution to the overall ecotoxicity. In conclusion, the inclusion of microplastic release into LCA only marginally influences the overall environmental effects of the two products in the LCA case studies.

Purpose The increasing use of engineered nanomaterials (ENMs) in industrial applications and consumer products is leading to an inevitable release of these materials into the environment. This makes it necessary to assess the potential risks that these new materials pose to human health and the environment. Life cycle assessment (LCA) methodology has been recognized as a key tool for assessing the environmental performance of nanoproducts. Until now, the impacts of ENMs could not be included in LCA studies due to a lack of characterization factors (CFs). This paper provides a methodological framework for identifying human health CFs for ENMs. Methods The USEtox™ model was used to identify CFs for assessing the potential carcinogenic and non-carcinogenic effects on human health caused by ENM emissions in both indoor (occupational settings) and outdoor environments. Nano-titanium dioxide (nano-TiO 2 ) was selected for defining the CFs in this study, as it is one of the most commonly used ENMs. For the carcinogenic effect assessment, a conservative approach was adopted; indeed, a critical dose estimate for pulmonary inflammation was assumed. Results and discussion We propose CFs for nano-TiO 2 from 5.5E−09 to 1.43E−02 cases/kg emitted for both indoor and outdoor environments and for carcinogenic and non-carcinogenic effects. Conclusions These human health CFs for nano-TiO 2 are an important step toward the comprehensive application of LCA methodology in the field of nanomaterial technology.

Currently, a noncomprehensive understanding of the physicochemical properties of carbon-based nanomaterial (CBNs), which may affect toxic effects, is still observable. In this study, an exploratory systematic investigation into the key physicochemical properties of multiwall carbon nanotube (MWCNT), single-wall carbon nanotube (SWCNT), and C 60 -fullerene on their ecotoxicity has been undertaken. We undertook an extensive survey of the literature pertaining to the ecotoxicity of organism representative of the trophic level of algae, crustaceans, and fish. Based on this, a set of data reporting both the physicochemical properties of carbon-based nanomaterial and the observed toxic effect has been established. The relationship between physicochemical properties and observed toxic effect was investigated based on various statistical approaches. Specifically, analysis of variance by one-way ANOVA was used to assess the effect of categorical properties (use of a dispersant or treatments in the test medium, type of carbon-based nanomaterial, i.e., SWCNT, MWCNT, C 60 -fullerene, functionalization), while multiple regression analysis was used to assess the effect of quantitative properties (i.e., diameter length of nanotubes, secondary size) on the toxicity values. The here described investigations revealed significant relationships among the physicochemical properties and observed toxic effects. The research was mainly affected by the low availability of data and also by the low variability of the studies collected. Overall, our results demonstrate that the here proposed and applied approach could have a major role in identifying the physicochemical properties of relevance for the toxicity of nanomaterial. However, the future success of the approach would require that the ENMs and the experimental conditions used in the toxicity studies are fully characterized.

The increasing use of engineered nanomaterials (ENMs) in industrial applications and consumer products is leading to an inevitable release of these materials into the environment. This makes it necessary to assess the potential risks that these new materials pose to human health and the environment. Life cycle assessment (LCA) methodology has been recognized as a key tool for assessing the environmental performance of nanoproducts. Until now, the impacts of ENMs could not be included in LCA studies due to a lack of characterization factors (CFs). This paper provides a methodological framework for identifying human health CFs for ENMs. The USEtox(TM) model was used to identify CFs for assessing the potential carcinogenic and non-carcinogenic effects on human health caused by ENM emissions in both indoor (occupational settings) and outdoor environments. Nano-titanium dioxide (nano-TiO sub(2)) was selected for defining the CFs in this study, as it is one of the most commonly used ENMs. For the carcinogenic effect assessment, a conservative approach was adopted; indeed, a critical dose estimate for pulmonary inflammation was assumed. We propose CFs for nano-TiO sub(2) from 5.5E-09 to 1.43E-02 cases/kg sub(emitted) for both indoor and outdoor environments and for carcinogenic and non-carcinogenic effects. These human health CFs for nano-TiO sub(2) are an important step toward the comprehensive application of LCA methodology in the field of nanomaterial technology.

Recent studies suggest that the ecotoxicity of engineered nanoparticles (ENPs) is dependent upon the treatment of ENPs in suspensions (e.g. sonication or use of solvents) and on the mode of exposure to test organisms. We conducted several bioassays with Daphnia magna in order to determine how adverse effects of TiO₂nanoparticles (n-TiO₂) are influenced by experimental set-up. Several treatments were applied, including three test media, several treatments of n-TiO₂suspensions (stirring, sonication) and different exposure modes (exposure duration and volume of test suspension). No adverse effects were observed when D. magna were exposed to 50 mL of suspension, regardless of TiO₂concentration (up to 250 mg/L) and exposure duration. Conversely, adverse effects were observed when D. magna were exposed to 2 mL of suspension for 96 h with a 50 % effect concentration EC₅₀values ranging from 32 mg/L to 82 mg/L. Test media had no significant influence on the outcome of all treatments. For a better mechanistic understanding of the experimental set-up at which adverse effects were observed, the particle size of n-TiO₂in the test media was characterized throughout the test duration. These measurements revealed a fast and strong agglomeration with a secondary particle size in the order of magnitude of micrometers. Our study describes how the effects of n-TiO₂on D .magna are influenced by the duration of exposure and volume of media, highlighting the need for standardization of experimental methods.

Recent studies suggest that the ecotoxicity of engineered nanoparticles (ENPs) is dependent upon the treatment of ENPs in suspensions (e.g. sonication or use of solvents) and on the mode of exposure to test organisms. We conducted several bioassays with Daphnia magna in order to determine how adverse effects of TiO sub(2) nanoparticles (n-TiO sub(2)) are influenced by experimental set-up. Several treatments were applied, including three test media, several treatments of n-TiO sub(2) suspensions (stirring, sonication) and different exposure modes (exposure duration and volume of test suspension). No adverse effects were observed when D. magna were exposed to 50 mL of suspension, regardless of TiO sub(2) concentration (up to 250 mg/L) and exposure duration. Conversely, adverse effects were observed when D. magna were exposed to 2 mL of suspension for 96 h with a 50 % effect concentration EC sub(50) values ranging from 32 mg/L to 82 mg/L. Test media had no significant influence on the outcome of all treatments. For a better mechanistic understanding of the experimental set-up at which adverse effects were observed, the particle size of n-TiO sub(2) in the test media was characterized throughout the test duration. These measurements revealed a fast and strong agglomeration with a secondary particle size in the order of magnitude of micrometers. Our study describes how the effects of n-TiO sub(2) on D .magna are influenced by the duration of exposure and volume of media, highlighting the need for standardization of experimental methods.