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Morphological diversity and connectivity of hippocampal interneurons
The mammalian forebrain is constructed from ensembles of neurons that form local microcircuits giving rise to the exquisite cognitive tasks the mammalian brain can perform. Hippocampal neuronal circuits comprise populations of relatively homogenous excitatory neurons, principal cells and exceedingly heterogeneous inhibitory neurons, the interneurons. Interneurons release GABA from their axon terminals and are capable of controlling excitability in every cellular compartment of principal cells and interneurons alike; thus, they provide a brake on excess activity, control the timing of neuronal discharge and provide modulation of synaptic transmission. The dendritic and axonal morphology of interneurons, as well as their afferent and efferent connections within hippocampal circuits, is central to their ability to differentially control excitability, in a cell-type- and compartment-specific manner. This review aims to provide an up-to-date compendium of described hippocampal interneuron subtypes, with respect to their morphology, connectivity, neurochemistry and physiology, a full understanding of which will in time help to explain the rich diversity of neuronal function.
Journal Article
Volitional social interaction prevents drug addiction in rat models
Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCδ-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments.
Journal Article
Handbook of executive functioning
Planning. Attention. Memory. Self-regulation. These and other core cognitive and behavioral operations of daily life comprise what we know as executive functioning (EF). But despite all we know, the concept has engendered multiple, often conflicting definitions, and its components are sometimes loosely defined and poorly understood. The Handbook of Executive Functioning cuts through the confusion, analyzing both the whole and its parts in comprehensive, practical detail for scholar and clinician alike. Background chapters examine influential models of EF, tour the brain geography of the executive system, and pose salient developmental questions. A section on practical implications relates early deficits in executive functioning to ADD and other disorders in children, and considers autism and later-life dementias from an EF standpoint. Further chapters weigh the merits of widely used instruments for assessing executive functioning and review interventions for its enhancement, with special emphasis on children and adolescents. Featured in the Handbook: The development of hot and cool executive function in childhood and adolescence. A review of the use of executive function tasks in externalizing and internalizing disorders. Executive functioning as a mediator of age-related cognitive decline in adults. Treatment integrity in interventions that target executive function. Supporting and strengthening working memory in the classroom to enhance executive functioning. The Handbook of Executive Functioning is an essential resource for researchers, scientist-practitioners, and graduate students in clinical child, school, and educational psychology; child and adolescent psychiatry; neurobiology; developmental psychology; rehabilitation medicine/therapy; and social work.
Book
Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood–brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting passage of circulating proinflammatory cytokines and depression-like behaviors. This effect is prominent within the nucleus accumbens, a brain region associated with mood regulation; however, the mechanisms involved are unclear. Moreover, compensatory responses leading to proper behavioral strategies and active resilience are unknown. Here we identify active molecular changes within the BBB associated with stress resilience that might serve a protective role for the neurovasculature. We also confirm the relevance of such changes to human depression and antidepressant treatment. We show that permissive epigenetic regulation of cldn5 expression and low endothelium expression of repressive cldn5-related transcription factor foxo1 are associated with stress resilience. Regionand endothelial cell-specific whole transcriptomic analyses revealed molecular signatures associated with stress vulnerability vs. resilience. We identified proinflammatory TNFα/NFκB signaling and hdac1 as mediators of stress susceptibility. Pharmacological inhibition of stress-induced increase in hdac1 activity rescued cldn5 expression in the NAc and promoted resilience. Importantly, we confirmed changes in HDAC1 expression in the NAc of depressed patients without antidepressant treatment in line with CLDN5 loss. Conversely, many of these deleterious CLDN5-related molecular changes were reduced in postmortem NAc from antidepressanttreated subjects. These findings reinforce the importance of considering stress-induced neurovascular pathology in depression and provide therapeutic targets to treat this mood disorder and promote resilience.
Journal Article
The serious leisure perspective : an introduction
\"The \"Serious Leisure Perspective\" (SLP) is a theoretical framework that can help us understand the complexities of modern leisure as both an activity and an experience. Bringing together the study of serious leisure, casual leisure and project-based leisure, it is an essential component of the Leisure Studies curriculum and an invaluable tool for exploring the significance of leisure in contemporary society. This book is the first of offer a comprehensive introduction to the Serious Leisure Perspective, from fundamental principles and key concepts to in-depth and wide-ranging case studies of serious leisure pursuits. The book introduces the history of the SLP and its position alongside other social theories that attempt to explain the nature and function of leisure. It explores important themes such as consumption, gender relations, social capital and quality of life, and delves deeply into the leisure of amateurs, hobbyists, career volunteers and occupational devotees. Every chapter includes a range of useful pedagogical features, such as review questions and group exercises, to help the student to grasp the importance of understanding leisure as a way of understanding contemporary social life and society. Combining cutting-edge theory and method with an engaging and practical interface, this is an essential text for all Leisure Studies courses and illuminating reading for any student working in Tourism, Events, Sport, Recreation, Sociology or Cultural Studies\"-- Provided by publisher.
Book
Understanding structure-activity relationships in linear polymer photocatalysts for hydrogen evolution
Conjugated polymers have sparked much interest as photocatalysts for hydrogen production. However, beyond basic considerations such as spectral absorption, the factors that dictate their photocatalytic activity are poorly understood. Here we investigate a series of linear conjugated polymers with external quantum efficiencies for hydrogen production between 0.4 and 11.6%. We monitor the generation of the photoactive species from femtoseconds to seconds after light absorption using transient spectroscopy and correlate their yield with the measured photocatalytic activity. Experiments coupled with modeling suggest that the localization of water around the polymer chain due to the incorporation of sulfone groups into an otherwise hydrophobic backbone is crucial for charge generation. Calculations of solution redox potentials and charge transfer free energies demonstrate that electron transfer from the sacrificial donor becomes thermodynamically favored as a result of the more polar local environment, leading to the production of long-lived electrons in these amphiphilic polymers.
While inorganic semiconductors are well-studied for their solar-to-fuel energy conversion abilities, organic materials receive far less attention. Here, authors prepare linear conjugated polymers as H
2
evolution photocatalysts and rationalize photocatalytic activities with fundamental properties.
Journal Article
Interventions for autism spectrum disorders : translating science into practice
Children are being diagnosed with autism spectrum disorders at a staggering rate-as many as one in 110, according to some studies. To this sobering statistic add the familiar figures of the toddler disengaged from his peers, the middle schooler shunned in the lunchroom, and the adult struggling with social cues on the job, and professionals are faced with a mounting challenge: to assist and support young people with these disorders to ensure their successful transition to adolescence and adulthood.
Book
Magnetized Fingering Convection in Stars
Fingering convection (also known as thermohaline convection) is a process that drives the vertical transport of chemical elements in regions of stellar radiative zones where the mean molecular weight increases with radius. Recently, Harrington & Garaud used three-dimensional direct numerical simulations (DNS) to show that a vertical magnetic field can dramatically enhance the rate of chemical mixing by fingering convection. Furthermore, they proposed a so-called “parasitic saturation” theory to model this process. Here, we test their model over a broad range of parameter space, using a suite of DNS of magnetized fingering convection, varying the magnetic Prandtl number, magnetic field strength, and composition gradient. We find that the rate of chemical mixing measured in the simulations is not always predicted accurately by their existing model, in particular when the magnetic diffusivity is large. We then present an extension of the Harrington & Garaud model which resolves this issue. When applied to stellar parameters, it recovers the results of Harrington & Garaud except in the limit where fingering convection becomes marginally stable, where the new model is preferred. We discuss the implications of our findings for stellar structure and evolution.
Journal Article