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Human exposure to floods continues to increase, driven by changes in hydrology and land use. Adverse impacts amplify for socially vulnerable populations, who disproportionately inhabit flood-prone areas. This study explores the geography of flood exposure and social vulnerability in the conterminous United States based on spatial analysis of fluvial and pluvial flood extent, land cover, and social vulnerability. Using bivariate Local Indicators of Spatial Association, we map hotspots where high flood exposure and high social vulnerability converge and identify dominant indicators of social vulnerability within these places. The hotspots, home to approximately 19 million people, occur predominantly in rural areas and across the US South. Mobile homes and racial minorities are most overrepresented in hotspots compared to elsewhere. The results identify priority locations where interventions can mitigate both physical and social aspects of flood vulnerability. The variables that most distinguish the clusters are used to develop an indicator set of social vulnerability to flood exposure. Understanding who is most exposed to floods and where, can be used to tailor mitigation strategies to target those most in need.

Elevation data are fundamental to many applications, especially in geosciences. The latest global elevation data contains forest and building artifacts that limit its usefulness for applications that require precise terrain heights, in particular flood simulation. Here, we use machine learning to remove buildings and forests from the Copernicus Digital Elevation Model to produce, for the first time, a global map of elevation with buildings and forests removed at 1 arc second (∼30 m) grid spacing. We train our correction algorithm on a unique set of reference elevation data from 12 countries, covering a wide range of climate zones and urban extents. Hence, this approach has much wider applicability compared to previous DEMs trained on data from a single country. Our method reduces mean absolute vertical error in built-up areas from 1.61 to 1.12 m, and in forests from 5.15 to 2.88 m. The new elevation map is more accurate than existing global elevation maps and will strengthen applications and models where high quality global terrain information is required.

Current flood risk mapping, relying on historical observations, fails to account for increasing threat under climate change. Incorporating recent developments in inundation modelling, here we show a 26.4% (24.1–29.1%) increase in US flood risk by 2050 due to climate change alone under RCP4.5. Our national depiction of comprehensive and high-resolution flood risk estimates in the United States indicates current average annual losses of US$32.1 billion (US$30.5–33.8 billion) in 2020’s climate, which are borne disproportionately by poorer communities with a proportionally larger White population. The future increase in risk will disproportionately impact Black communities, while remaining concentrated on the Atlantic and Gulf coasts. Furthermore, projected population change (SSP2) could cause flood risk increases that outweigh the impact of climate change fourfold. These results make clear the need for adaptation to flood and emergent climate risks in the United States, with mitigation required to prevent the acceleration of these risks.Climate change is increasing flood risk, yet models based on historical data alone cannot capture the impact. Granular mapping of national flood risk shows that losses caused by flooding in the United States will increase substantially by 2050 and disproportionately burden less advantaged communities.

Climate change is already increasing the severity of extreme weather events such as with rainfall during hurricanes. But little research to date investigates if, and to what extent, there are social inequalities in climate change-attributed extreme weather event impacts. Here, we use climate change attribution science paired with hydrological flood models to estimate climate change-attributed flood depths and damages during Hurricane Harvey in Harris County, Texas. Using detailed land-parcel and census tract socio-economic data, we then describe the socio-spatial characteristics associated with these climate change-induced impacts. We show that 30 to 50% of the flooded properties would not have flooded without climate change. Climate change-attributed impacts were particularly felt in Latina/x/o neighborhoods, and especially so in Latina/x/o neighborhoods that were low-income and among those located outside of FEMA’s 100-year floodplain. Our focus is thus on climate justice challenges that not only concern future climate change-induced risks, but are already affecting vulnerable populations disproportionately now. New study shows that up to 50% of properties flooded after hurricane Harvey flooded because of climate change, with low-income and Latina/x/o neighborhoods experiencing higher climate change-attributed impacts.

Past attempts to estimate rainfall-driven flood risk across the US either have incomplete coverage, coarse resolution or use overly simplified models of the flooding process. In this paper, we use a new 30 m resolution model of the entire conterminous US with a 2D representation of flood physics to produce estimates of flood hazard, which match to within 90% accuracy the skill of local models built with detailed data. These flood depths are combined with exposure datasets of commensurate resolution to calculate current and future flood risk. Our data show that the total US population exposed to serious flooding is 2.6-3.1 times higher than previous estimates, and that nearly 41 million Americans live within the 1% annual exceedance probability floodplain (compared to only 13 million when calculated using FEMA flood maps). We find that population and GDP growth alone are expected to lead to significant future increases in exposure, and this change may be exacerbated in the future by climate change.

Current estimates of global flood exposure are made using datasets that distribute population counts homogenously across large lowland floodplain areas. When intersected with simulated water depths, this results in a significant mis-estimation. Here, we use new highly resolved population information to show that, in reality, humans make more rational decisions about flood risk than current demographic data suggest. In the new data, populations are correctly represented as risk-averse, largely avoiding obvious flood zones. The results also show that existing demographic datasets struggle to represent concentrations of exposure, with the total exposed population being spread over larger areas. In this analysis we use flood hazard data from a ~90 m resolution hydrodynamic inundation model to demonstrate the impact of different population distributions on flood exposure calculations for 18 developing countries spread across Africa, Asia and Latin America. The results suggest that many published large-scale flood exposure estimates may require significant revision. Flood risk modelling neglects the location of people and assets. Here the authors applied machine learning techniques and high-resolution population data to reinvestigate the impact of population distributions on flood exposure and showed that populations are generally represented as risk-averse and largely avoiding obvious flood zones.

Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some of these peptides have essential and conserved cellular functions. In Drosophila, we have predicted a particular smORF class encoding ~80 aa hydrophobic peptides, which may function in membranes and cell organelles. Here, we characterise hemotin, a gene encoding an 88aa transmembrane smORF peptide localised to early endosomes in Drosophila macrophages. hemotin regulates endosomal maturation during phagocytosis by repressing the cooperation of 14-3-3ζ with specific phosphatidylinositol (PI) enzymes. hemotin mutants accumulate undigested phagocytic material inside enlarged endo-lysosomes and as a result, hemotin mutants have reduced ability to fight bacteria, and hence, have severely reduced life span and resistance to infections. We identify Stannin, a peptide involved in organometallic toxicity, as the Hemotin functional homologue in vertebrates, showing that this novel regulator of phagocytic processing is widely conserved, emphasizing the significance of smORF peptides in cell biology and disease.

Global flood mapping has developed rapidly over the past decade, but previous approaches have limited scope, function, and accuracy. These limitations restrict the applicability and fundamental science questions that can be answered with existing model frameworks. Harnessing recently available data and modeling methods, this paper presents a new global ∼30 m resolution Global Flood Map (GFM) with complete coverage of fluvial, pluvial, and coastal perils, for any return period or climate scenario, including accounting for uncertainty. With an extensive compilation of global benchmark case studies—ranging from locally collected event water levels, to national inventories of engineering flood maps—we execute a comprehensive validation of the new GFM. For flood extent comparisons, we demonstrate that the GFM achieves a critical success index of ∼0.75. In the more discriminatory tests of flood water levels, the GFM deviates from observations by ∼0.6 m on average. Results indicating this level of global model fidelity are unprecedented in the literature. With an optimistic scenario of future warming (SSP1‐2.6), we show end‐of‐century global flood hazard (average annual inundation volume) increases are limited to 9% (likely range ‐6%–29%); this is within the likely climatological uncertainty of −8%–12% in the current hazard estimate. In contrast, pessimistic scenario (SSP5‐8.5) hazard changes emerge from the background noise in the 2040s, rising to a 49% (likely range of 7%–109%) increase by 2100. This work verifies the fitness‐for‐purpose of this new‐generation GFM for impact analyses with a variety of beneficial applications across policymaking, planning, and commercial risk assessment. Plain Language Summary Computer models use a variety of data and physical equations to estimate the extent and depth of possible flood events. Global applications of these tools have been developed over the past decade, but they are not very good at simulating the behavior of real floods. In this paper, we address some key problems to make a global model that does a lot better than past ones. We apply new techniques to better understand how much water we need to put into the model for a given flood probability. This movement of water is simulated by the model over a more accurate map of the Earth's terrain than has been available previously, with river channels represented in a smarter way. We look at the projected changes in rainfall, river discharge, and sea levels for given levels of warming simulated by available climate models and adjust the probabilities of a given magnitude flood accordingly. The model results suggest that the effect of future climate change might be small relative to our ability to understand flood hazards today, but this depends heavily on how much carbon we emit in the coming decades. Key Points New climate‐conditioned model framework represents fluvial, pluvial, and coastal flood hazards at high‐resolution globally Comprehensive validation studies suggest that the model is approaching local model skill in many cases Emissions reduction can hold flood hazards largely constant this century, though coastal flooding will increase drastically regardless