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The co-monarchy of Mary I and Philip II put England at the heart of early modern Europe. This positive reassessment of their joint reign counters a series of parochial, misogynist and anti-Catholic assumptions, correcting the many myths that have grown up around the marriage and explaining the reasons for its persistent marginalisation in the historiography of sixteenth-century England. Using new archival discoveries and original sources, the book argues for Mary as a great Catholic queen, while fleshing out Philip’s important contributions as king of England. It demonstrates the many positive achievements of this dynastic union in everything from culture, music and art to cartography, commerce and exploration. An important corrective for anyone interested in the history of Tudor England and Habsburg Spain.

This paper presents a preliminary 100-item Swadesh word list for Hnaring Lutuv. Lutuv or Lautu(ISO 639-3 CLT) belongs to the Maraic branch of Kuki-Chin within the Tibeto-Burman language family (Eberhard et. al, 2019). Hnaring is a Lutuv village in the southern part of the Lutuv-speaking area in Thantlang Township, Chin State, Myanmar The word list comes from the intuitions of our co-author Sui Hnem Par,a 21-year-old native speaker born Near Mandalay of Lutuv parents (both from Hnaring), who lived for some of her childhood in Hnaring before moving to the US.

Zophei is an undescribed Tibeto-Burman language within the Kuki-Chin family. Originally spoken in the Chin Hills of Western Myanmar, approximately 4,000 Zophei-speaking refugees now live in Central Indiana. No previous research on Zophei exists. The speakers located in Indiana who identify as ethnically Zophei hail from 14 distinct villages, and it is not yet known how many dialects or languages are represented. As part of a larger effort to kick-start a research program on Zophei, the current study presents vowel spaces for two speakers, one from Tlawngrang and one from Lawngtlang. Differences with regard to the number and distribution of high vowels and diphthongs indicate that these two areas speak different varieties with markedly different phonologies. For example, where one speaker has an /ui/ diphthong the other speaker consistently has the front rounded monophthong /y/. This research contributes to our ultimate goal, which is to determine the dialectal make-up of Zophei and to develop a description of the language or languages spoken by the ethnic Zophei population in Indiana.  

Welcome to the inaugural volume of IWPSALC. In creating this publication—inspired by progress reports like those published from 1965 through 1995 as the Haskins Laboratories Status Report on Speech Research—we seek to encourage scholars to publish discrete portions of their research while they work towards full papers. The papers included herein are a small sampling of the work that began in Spring 2018, work which will be presented at future conferences, be expanded for other publications, and serve as the basis for future dissertations. Since much of the research is still ongoing, in a sense this volume provides a sneak peek at things yet to come. Topics touched on range from the phonetic to the syntactic to the descriptive. Thank you for picking up this volume and showing interest. We hope the contents are of interest and we look forward to future conversations.  

Ferroptosis, a type of iron-dependent programmed cell death distinct from apoptosis, necroptosis, and other types of cell death, is characterized by lipid peroxidation, reactive oxygen species production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury. Therefore, ferroptosis has become a major focus for translational research. However, despite its involvement in pathological conditions, there are no pharmacologic inhibitors of ferroptosis in clinical use. In the context of drug repurposing, a strategy for identifying new uses for approved drugs outside the original medical application, we discovered that vitamin K1 is an efficient inhibitor of ferroptosis. Our findings are strengthened by the fact that the vitamin K antagonist phenprocoumon significantly exacerbated ferroptotic cell death in vitro and also massively worsened the course of acute kidney injury in vivo, which is of utmost clinical importance. We therefore assign vitamin K1 a novel role in preventing ferroptotic cell death in acute tubular necrosis during acute kidney injury. Since the safety, tolerability, pharmacokinetics, and pharmacodynamics of vitamin K1 formulations are well documented, this drug is primed for clinical application, and provides a new strategy for pharmacological control of ferroptosis and diseases associated with this mode of cell death.

England's ambassador in Madrid from 1620 to 1624 and from 1635 to 1638, Sir Walter Aston was a fluent speaker of Castilian and convert to Catholicism. His interest in Spanish literary culture, in circulation of poetry in manuscript, and in translation played a key role in his negotiation of the religious and political differences that affected him and his circle personally and divided the state he served. The Astons' ambivalent position made them valuable intermediaries and at the same time vulnerably peripheral. Alexander Samson identifies a key performance witnessed by Aston in Spain on the eve of the Spanish match that is linked with a sonnet found in Secretary of State Edward Conway's papers and with the later translation by Aston's secretary, Sir Richard Fanshawe, of Antonio Hurtado de Mendoza's play Querer por sólo querer.

This paper presents a preliminary 100-item Swadesh word list for Lawngtlang Zophei. Zophei or Zyphe (ISO 639-3 ZYP) belongs to the Maraic branch of Kuki-Chin within the Tibeto-Burman language family (Eberhard et. al, 2019). Lawngtlang is a Zophei village in the Southeastern corner of the Zophei-speaking area in Thantlang Township, Chin State, Myanmar. Lawngtlang Zophei is considered to be part of the Lower (western) dialects of Zophei. The word list comes from the intuitions of our co-author Zai Sung, a 22-year-old native speaker born in Lawngtlang and currently living in Indianapolis, Indiana.

The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation. Recent studies suggest that RIPK1 inhibition would fundamentally improve the therapy of RIPK1-dependent organ damage in stroke, myocardial infarction, kidney failure, and systemic inflammatory response syndrome. Additionally, it could ameliorate or prevent multi-organ failure induced by cytokine release in the context of hyperinflammation, as seen in COVID-19 patients. Therefore, we searched for a RIPK1 inhibitor and present the aromatic antiepileptic and FDA-approved drug primidone (Liskantin®) as a potent inhibitor of RIPK1 activation in vitro and in a murine model of TNFα-induced shock, which mimics the hyperinflammatory state of cytokine release syndrome. Furthermore, we detected for the first time RIPK1 activation in the respiratory tract epithelium of hospitalized patients who tested positive for SARS-CoV-2 infection. Our data provide a strong rationale for evaluating the drug primidone in conditions of hyperinflammation in humans.