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IntroductionHaemophilia A is a rare bleeding disorder caused by defects in coagulation factor VIII (FVIII). Damoctocog alfa pegol (BAY 94–9027, Jivi, Bayer, Germany) is a site-specifically PEGylated, extended-half-life, recombinant FVIII, approved for use in previously treated patients (PTPs) aged ≥12 years with haemophilia A. However, a real-world evidence regarding routine clinical use of damoctocog alfa pegol is limited.Methods and analysisHEM-POWR is a multinational, multicentre, non-interventional, prospective, postmarketing cohort study evaluating the effectiveness and safety of real-world treatment with damoctocog alfa pegol. Estimated enrolment is ≥200 PTPs with haemophilia A, receiving damoctocog alfa pegol (on-demand, prophylaxis or intermittent prophylaxis (as per local label)), observed for 36 months. Primary outcomes are total bleeding events and annualised bleeding rate; secondary outcomes include long-term safety, joint health, pharmacokinetics, patient-reported outcomes (PROs) from validated questionnaires and perioperative haemostasis. Where applicable, reasons for switching to damoctocog alfa pegol, choice of treatment regimen and dose will also be captured. Exploratory and descriptive statistical analyses will be performed, and will be stratified by parameters including, but not limited to, prophylaxis regimen and haemophilia severity. Patients can record bleeds and consumption in electronic (e) Diaries, ePROs, and can access non-promotional study information (videos explaining study procedures) via an online patient portal. Optionally, patients can enrol in the LIFE-ACTIVE substudy designed to investigate the relationship between activity (measured by the ActiGraph CP Insight watch) and effectiveness parameters collected from HEM-POWR.Ethics and disseminationStudy approval was obtained by local independent ethics committees and authorities in participating study centres across Europe, the Americas and Asia. Informed consent from patients or their legal representative is a requirement for participation. The study results will be submitted for publication in a peer-reviewed scientific journal and presented at scientific conferences.Trial registration numbers NCT03932201, EUPAS26416.Protocol version and dateV.1.2, 27 September 2019.

Background Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of pulmonary TB cases and its relationship with concentration of biochemical parameters in peripheral blood. Methods A retrospective cross-sectional study used data from 132 microbiologically confirmed pulmonary TB patients from Lima, Peru, evaluated in a previous investigation performed between February and December 2017. Chest radiographs were analyzed by a radiologist and a pulmonologist. Radiographic lesions were identified as cavities, alveolar infiltrates and fibrous tracts. Hyperglycemia in TB patients was identified by use of fasting plasma glucose, HbA1c and oral glucose tolerance test. Clinical, biochemical and hematological parameters were also analyzed. Results TB patients with hyperglycemia presented more frequently with cavities, alveolar infiltrates and fibrous tracts than those with normoglycemia. Hierarchical clustering analysis indicated that patients with more diverse and higher number of lung lesions exhibited a distinct laboratorial profile characterized by heightened white blood cell counts and circulating levels of total cholesterol, triglycerides and transaminases and simultaneously low levels of albumin and hemoglobin. Multivariable regression analyses adjusted for age, sex, prior TB, hemoglobin levels and acid-fast bacilli ≥2+ in sputum smears, demonstrated that presence of prediabetes or diabetes in TB patients was associated with increased odds of having 3 pulmonary lesion types ( p  = 0.003 and p  < 0.01 respectively) or ≥ 4 lesions ( p  = 0.001 and p  = 0.01 respectively). Conclusion Hyperglycemia (both DM and prediabetes) significantly affected the presentation of radiographic manifestations and the number of lesions in pulmonary TB patients as well as the biochemical profile in peripheral blood.

Following the approaches of Fisher, Koo, and in particular Minsky, this article describes recent developments in the Spanish economy. These authors? theories of financial fragility, and the extension of analysis of the recession to also include the expansionary period, are very useful when it comes to understanding the boom (1994-2008) and subsequent collapse of the Spanish economy. Both processes are part of the same phenomenon: the binomial relation between debt and the asset bubble, amplified by the use of external financing, and the subsequent process of slow deleveraging. Alongside said analytical elements, and considering Spain?s membership in the Eurozone monetary union system, this characterisation of the euphoria and subsequent balance-sheet recession further identifies specific features of the Spanish economy that informed current outcomes. nema

In general terms, the term financiarization refers to rising relevance of nancial capital within business operation . Financial activity is not only expanding rapidly, but also alters its composition in terms of markets, products and agents . These changes are deep enough to affect the logic behind economic performance . In most developed economies and some underdeveloped, the non-nancial companies act under the logic of the nancial sector . As a result, economic activity is nancializated and leads many problems of weakening demand, slowing the accumulation process and social reconguration that are prejudicial to working people and benet the capital, particulary its nancier faction . Numerous problems which have nally led to the current crisis. [PUBLICATION ABSTRACT]

Con el término de “financiarización” se alude, en general, al ascenso de la importancia del capital financiero dentro del funcionamiento económico. La actividad financiera no sólo se expande vertiginosamente, sino que también altera su composición en términos de mercados, productos y agentes protagonistas. Estos cambios tienen la profundidad suficiente como para afectar a la lógica que rige el funcionamiento económico. En la mayor parte de las economías desarrolladas y en una parte de las subdesarrolladas, las empresas del sector no financiero, las familias y los gobiernos actúan sometidos a esa lógica propia del sector financiero. Como resultado, la actividad económica se “financiariza” y da lugar a numerosos problemas que provocan el debilitamiento de la demanda, la ralentización del proceso de acumulación y una reconfiguración social que perjudica a los trabajadores y beneficia al capital, particularmente a su facción financiera. Numerosos problemas que finalmente han desembocado en la actual crisis.

In general terms, the term financiarization refers to rising relevance of nancial capital within business operation . Financial activity is not only expanding rapidly, but also alters its composition in terms of markets, products and agents . These changes are deep enough to affect the logic behind economic performance . In most developed economies and some underdeveloped, the non-nancial companies act under the logic of the nancial sector . As a result, economic activity is nancializated and leads many problems of weakening demand, slowing the accumulation process and social reconguration that are prejudicial to working people and benet the capital, particulary its nancier faction . Numerous problems which have nally led to the current crisis.

Las políticas de atracción de Inversión Extranjera Directa experimentaron un cambio significativo durante la década de los ochenta. Este cambio ha tenido como objetivo fundamental crear las condiciones más favorables posibles a la llegada de estas inversiones. Si la deslocalización de la producción industrial ya venía siendo un fenómeno significativo desde prácticamente el final de la Segunda Guerra Mundial, no ocurría lo mismo en el caso del sector servicios. Por ello, uno de los aspectos más novedosos de estas nuevas políticas de atracción ha sido la liberalización y privatización de estos sectores, hechos que han favorecido la expansión internacional de algunas empresas, particularmente europeas y estadounidenses.