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Dreamweaver CS5.5
\"Dreamweaver is the tool most widely used to design and manage professional-looking websites, but it's a complex program. That's where 'Dreamweaver CS5.5: The Missing Manual' comes in. With its jargon-free explanations, 13 hands-on tutorials, and savvy advice from Dreamweaver expert Dave McFarland, you'll master this versatile program with ease.\"--P. [4] of cover.
Book
Fundamental aspects of interpreter education : curriculum and assessment
The author offers an overview of the Interpreting Studies literature on curriculum and assessment. A discussion of curriculum definitions, foundations, and guidelines suggests a framework based upon scientific and humanistic approaches - curriculum as process and as interaction. Language testing concepts are introduced and related to interpreting. By exploring means of integrating valid and reliable assessment into the curriculum, the author breaks new ground in this under-researched area.Case studies of degree examinations provide sample data on pass/fail rates, test criteria, and text selection. A curriculum model is outlined as a practical example of synthesis, flexibility, and streamlining.This volume will appeal to interpretation and translation instructors, program administrators, and language industry professionals seeking a discussion of the theoretical and practical aspects of curriculum and assessment theory. This book also presents a new area of application for curriculum and language testing specialists.
eBook
فتى الفضاء
تدور أحداث هذه القصة في السنوات الأولى من ذلك العقد في مزرعة قديمة في بلدة وسط غرب الولايات المتحدة، بلدة لا يحدث فيها أي شيء على الإطلاق إلى أن تبدأ مغامرة العمر بين أبطال قصة فتى الفضاء في أعماق مزرعة عمتها النائية في أميركا، تعيش \"روث\"، الطفلة اليتيمة ذات الاثنى عشر عاما، وتحلم بالمغامرات التي تختبئ في أروقة التاريخ كل ليلة تنظر \"روث\" إلى السماء المرصوفة بالنجوم، وتتسائل عن العوالم البعيدة والكواكب القريبة التي قد تكون مليئة بالحياة والمخلوقات الفضائية لكن ذات ليلة، حدث شيء غير متوقع قلب حياة \"روث\" رأسا على عقب ففي الوقت الذي كانت تحدق فيه إلى النجوم، اكتشفت ضوءا ساطعا يتسلل من السماء وينزلق نحو الحقل المجاور إنه صحن طائر هبط بهدوء، ومن داخله خرج كائن غريب لا يشبه أي شيء رأته من قبل رهبة المجهول تحولت إلى إثارة ودهشة عندما تبين أن هذا الكائن الفضائي كان يمتلك قدرات خارقة وقوى لا تصدق.
Book
State of the Field: Extreme Precision Radial Velocities
The Second Workshop on Extreme Precision Radial Velocities defined circa 2015 the state of the art Doppler precision and identified the critical path challenges for reaching 10 cm s(-1) measurement precision. The presentations and discussion of key issues for instrumentation and data analysis and the workshop recommendations for achieving this bold precision are summarized here. Beginning with the High Accuracy Radial Velocity Planet Searcher spectrograph, technological advances for precision radial velocity (RV) measurements have focused on building extremely stable instruments. To reach still higher precision, future spectrometers will need to improve upon the state of the art, producing even higher fidelity spectra. This should be possible with improved environmental control, greater stability in the illumination of the spectrometer optics, better detectors, more precise wavelength calibration, and broader bandwidth spectra. Key data analysis challenges for the precision RV community include distinguishing center of mass (COM) Keplerian motion from photospheric velocities (time correlated noise) and the proper treatment of telluric contamination. Success here is coupled to the instrument design, but also requires the implementation of robust statistical and modeling techniques. COM velocities produce Doppler shifts that affect every line identically, while photospheric velocities produce line profile asymmetries with wavelength and temporal dependencies that are different from Keplerian signals. Exoplanets are an important subfield of astronomy and there has been an impressive rate of discovery over the past two decades. However, higher precision RV measurements are required to serve as a discovery technique for potentially habitable worlds, to confirm and characterize detections from transit missions, and to provide mass measurements for other space-based missions. The future of exoplanet science has very different trajectories depending on the precision that can ultimately be achieved with Doppler measurements.
Journal Article
A pathway design framework for national low greenhouse gas emission development strategies
The Paris Agreement introduces long-term strategies as an instrument to inform progressively more ambitious emission reduction objectives, while holding development goals paramount in the context of national circumstances. In the lead up to the twenty-first Conference of the Parties, the Deep Decarbonization Pathways Project developed mid-century low-emission pathways for 16 countries, based on an innovative pathway design framework. In this Perspective, we describe this framework and show how it can support the development of sectorally and technologically detailed, policy-relevant and country-driven strategies consistent with the Paris Agreement climate goal. We also discuss how this framework can be used to engage stakeholder input and buy-in; design implementation policy packages; reveal necessary technological, financial and institutional enabling conditions; and support global stocktaking and increasing of ambition.The Deep Decarbonization Pathways Project develops a framework to design low-emission development pathways. This Perspective discusses the framework and how it can support the development of national strategies to meet climate targets, as well as help achieve stakeholder engagement.
Journal Article
Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells
Background
Intracranial aneurysms (IA) are increasingly recognized as a disease driven by chronic inflammation. Recent research has identified key mediators and processes underlying IA pathogenesis, but mechanistic understanding remains incomplete. Lymphocytic infiltrates have been demonstrated in patient IA tissue specimens and have also been shown to play an important role in abdominal aortic aneurysms (AAA) and related diseases such as atherosclerosis. However, no study has systematically examined the contribution of lymphocytes in a model of IA.
Methods
Lymphocyte-deficient (Rag1) and wild-type (WT; C57BL/6 strain) mice were subjected to a robust IA induction protocol. Rates of IA formation and rupture were measured, and cerebral artery tissue was collected and utilized for histology and gene expression analysis.
Results
At 2 weeks, the Rag1 group had significantly fewer IA formations and ruptures than the WT group. Histological analysis of unruptured IA tissue showed robust B and T lymphocyte infiltration in the WT group, while there were no differences in macrophage infiltration, IA diameter, and wall thickness. Significant differences in interleukin-6 (IL-6), matrix metalloproteinases 2 (MMP2) and 9 (MMP9), and smooth muscle myosin heavy chain (MHC) were observed between the groups.
Conclusions
Lymphocytes are key contributors to IA pathogenesis and provide a novel target for the prevention of IA progression and rupture in patients.
Journal Article
Inflammatory Mediators in Vascular Disease: Identifying Promising Targets for Intracranial Aneurysm Research
Inflammatory processes are implicated in many diseases of the vasculature and have been shown to play a key role in the formation of intracranial aneurysms (IAs). Although the specific mechanisms underlying these processes have been thoroughly investigated in related pathologies, such as atherosclerosis, there remains a paucity of information regarding the immunopathology of IA. Cells such as macrophages and lymphocytes and their effector molecules have been suggested to be players in IA, but their specific interactions and the role of other components of the inflammatory response have yet to be determined. Drawing parallels between the pathogenesis of IA and other vascular disorders could provide a roadmap for developing a mechanistic understanding of the immunopathology of IA and uncovering useful targets for therapeutic intervention. Future research should address the presence and function of leukocyte subsets, mechanisms of leukocyte recruitment and activation, and the role of damage-associated molecular patterns in IA.
Journal Article
The evolving curriculum in interpreter and translator education : stakeholder perspectives and voices
The Evolving Curriculum in Interpreter and Translator Education: Stakeholder perspectives and voices examines forces driving curriculum design, implementation and reform in academic programs that prepare interpreters and translators for employment in the public and private sectors.
eBook
Performance of overnight on-call radiology residents in interpreting unenhanced abdominopelvic magnetic resonance imaging studies performed for pediatric right lower quadrant abdominal pain
BackgroundAbdominopelvic magnetic resonance imaging (MRI) is increasingly being used to evaluate children with abdominal pain suspected of having acute appendicitis. At our institution, these examinations are preliminarily interpreted by radiology residents, especially when performed after hours.ObjectiveTo determine the accuracy of preliminary reports rendered by radiology residents in this setting.Materials and methodsThree hundred seventy-seven pediatric abdominopelvic MRI examinations were included. The preliminary (resident) and final (attending) radiology reports were coded as diagnosing acute appendicitis or no acute appendicitis. The concordance between resident and attending radiologist interpretations was calculated. Additionally, both resident and attending reports were compared to available surgical pathology or clinical follow-up data.ResultsOverall concordance rate for the diagnosis of acute appendicitis was 97.1%. Concordance for verified cases of acute appendicitis was 93.4%. Concordance rates did not differ by residents’ postgraduate year levels. When compared against surgical pathology or clinical follow-up data, residents demonstrated 91.2% sensitivity and 97.6% specificity. There was no statistically significant difference in the sensitivity or specificity of resident or attending radiologist interpretations.ConclusionRadiology residents demonstrate high concordance with attending pediatric radiologists in their interpretations of pediatric abdominopelvic MRI for acute appendicitis. The diagnostic performances of residents and attendings were comparable.
Journal Article
A Method for Mapping Hunting Occurrence Using Publicly Available, Geographic Variables
The spatial distribution of land available for hunting has received scant attention in the literature, but it fundamentally affects the feasibility of wildlife management. Modeling the distribution of hunting lands can be logistically difficult because of data requirements and the dynamic nature of landscapes and landowner preferences. We describe one approach to address this challenge using spatially explicit logistic regression models that accurately predict whether each parcel of land in North Carolina, USA, was hunted using free and publicly available geographic predictors. We collected data to develop and validate models from surveys of nonindustrial (n = 1,936) and industrial (n = 670) private landowners conducted during 2016 in North Carolina. Property size and housing and road density predicted whether hunting occurred correctly on 96% of nonindustrial parcels. Property size, housing and road density, and distance to the nearest city correctly predicted whether hunting occurred for 94% of industrial parcels. These results suggest wildlife managers may be able to accurately map and quantify where hunting occurs using relatively few publicly available geographic predictors. Future refinement of the methodology and model parameters is likely needed in different regions, with independent data sets, before adopting widespread implementation of underlying methods. This mapping method will facilitate assessing the efficacy of hunting as a wildlife management tool for overabundant species. Similarly the mapping approach would improve wildlife population estimates based on hunter harvest data by providing a more rigorous estimate of land that is huntable per harvested animal reported.
Journal Article