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Far-ultraviolet observations of the nearby low-mass star-forming galaxy J0925+1403 show that the galaxy is leaking ionizing radiation with an escape fraction of about 8 per cent, which is sufficient to ionize intergalactic medium material that is about 40 times as massive as the stellar mass of the galaxy. Observation of a 'reionizing' galaxy The early Universe went through a period known as the cosmic 'Dark Ages', when matter was largely transparent to radiation and transformed to neutral gas. Later, some 800 million years after the Big Bang, it was ionized again. Which sources were responsible for this re-ionization? Low-mass, star-forming galaxies are prime candidates, but are hard to observe. Here Yuri Izotov et al . present far-ultraviolet observations of a nearby low-mass star-forming galaxy that can be considered a proxy for the reionizing galaxy population. The galaxy, J0925+1403, is leaking ionizing radiation with an escape fraction of ∼8 per cent. The total number of photons emitted during the starburst phase is sufficient to ionize intergalactic medium material that is about 40 times as massive as the stellar mass of the galaxy. One of the key questions in observational cosmology is the identification of the sources responsible for ionization of the Universe after the cosmic ‘Dark Ages’, when the baryonic matter was neutral. The currently identified distant galaxies are insufficient to fully reionize the Universe by redshift z  ≈ 6 (refs 1 , 2 , 3 ), but low-mass, star-forming galaxies are thought to be responsible for the bulk of the ionizing radiation 4 , 5 , 6 . As direct observations at high redshift are difficult for a variety of reasons, one solution is to identify local proxies of this galaxy population. Starburst galaxies at low redshifts, however, generally are opaque to Lyman continuum photons 7 , 8 , 9 . Small escape fractions of about 1 to 3 per cent, insufficient to ionize much surrounding gas, have been detected only in three low-redshift galaxies 10 , 11 . Here we report far-ultraviolet observations of the nearby low-mass star-forming galaxy J0925+1403. The galaxy is leaking ionizing radiation with an escape fraction of about 8 per cent. The total number of photons emitted during the starburst phase is sufficient to ionize intergalactic medium material that is about 40 times as massive as the stellar mass of the galaxy.

Thanks to deep optical to near-IR imaging and spectroscopy, significant progress is made in characterizing the rest-frame UV to optical properties of galaxies in the early universe (z > 4. Surveys with Hubble, Spitzer, and ground-based facilities (Keck, Subaru, and VLT) provide spectroscopic and photometric redshifts, measurements of the spatial structure, stellar masses, and optical emission lines for large samples of galaxies. Recently, the Atacama Large (Sub) Millimeter Array (ALMA) has become a major player in pushing studies of high redshift galaxies to far-infrared wavelengths, hence making panchromatic surveys over many orders of frequencies possible. While past studies focused mostly on bright sub-millimeter galaxies, the sensitivity of ALMA now enables surveys like ALPINE, which focuses on measuring the gas and dust properties of a large sample of normal main-sequence galaxies at z > 4. Combining observations across different wavelengths into a single, panchromatic picture of galaxy formation and evolution is currently and in the future an important focus of the astronomical community.

Many cancer chemotherapeutic agents form DNA interstrand crosslinks (ICLs), extremely cytotoxic lesions that form covalent bonds between two opposing DNA strands, blocking DNA replication and transcription. However, cellular responses triggered by ICLs can cause resistance in tumor cells, limiting the efficacy of such treatment. Here we discuss recent advances in our understanding of the mechanisms of ICL repair that cause this resistance. The recent development of strategies for the synthesis of site-specific ICLs greatly contributed to these insights. Key features of repair are similar for all ICLs, but there is increasing evidence that the specifics of lesion recognition and synthesis past ICLs by DNA polymerases are dependent upon the structure of ICLs. These new insights provide a basis for the improvement of antitumor therapy by targeting DNA repair pathways that lead to resistance to treatment with crosslinking agents.

The ALMA-ALPINE [CII] survey (A2C2S) aims at characterizing the properties of normal star-forming galaxies (SFGs) observed in the [CII]-158 μ m line in the period of rapid mass assembly at redshifts 4 < z < 6. Here we present the survey and the selection of 118 galaxies observed with ALMA, selected from large samples of galaxies with spectroscopic redshifts derived from UV-rest frame. The observed properties derived from the ALMA data are presented and discussed in terms of the overall detection rate in [CII] and far-IR continuum. The sample is representative of the SFG population at these redshifts. The overall detection rate is 61% down to a flux limit of 0.07 mJy. From a visual inspection of the [CII] data cubes together with the large wealth of ancillary data we find a surprisingly wide range of galaxy types, including 32.4% mergers, 25.7% extended and dispersion dominated, 13.5% rotating discs, and 16.2% compact, the remaining being too faint to be classified. ALPINE sets a reference sample for the gas distribution in normal star-forming galaxies at a key epoch in galaxy assembly, ideally suited for studies with future facilities like JWST and ELTs.

The Ly α line is an important diagnostic of star formation and activity in galaxies. The analysis of Ly α is complicated due to the resonant nature of the line and radiative transfer effects. High spectral resolution studies of local starburst galaxies with the unprecedented UV capabilities of the HST have shown that this line is either seen in absorption or in emission and in the latter case with a P Cygni profile indicative of a large scale outflow of neutral gas. Moreover, HST imaging obtained with HST-ACS of a sample of 6 star-forming galaxies has revealed that a substantial fraction of the Ly α photons are diffused far away from the emissive knots. Since the importance of Ly α for tracing large scale structure, correlation functions, and galaxy formation is recognized, Ly α will remain a very important probe of the distant universe for the foreseeable future, and it is therefore imperative to acquire a better understanding of what mechanisms regulate our ability to detect this line.

Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by genomic instability and cellular hypersensitivity to chemicals that generate DNA interstrand cross-links (ICLs). A central event in the activation of the Fanconi anemia pathway is the mono-ubiquitylation of the FANCI-FANCD2 complex, but how this complex confers ICL resistance remains enigmatic. Using a cell-free system, we showed that FANCI-FANCD2 is required for replication-coupled ICL repair in S phase. Removal of FANCD2 from extracts inhibits both nucleolytic incisions near the ICL and translesion DNA synthesis past the lesion. Reversal of these defects requires ubiquitylated FANCI-FANCD2. Our results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised.

We summarise the current status of our project to identify and classify ~6-10 galaxies thanks to strong gravitational lensing. Building on the detailed work by Richard et al. (2006), we present results from new follow-up observations undertaken with the ACS/HST and the Spitzer space telescope and compare our results with findings from the Hubble Ultra-Deep Field (UDF). [PUBLICATION ABSTRACT]

We developped a 3D Monte Carlo Lyα radiation transfer code to understand the diversity of Lyα line profiles observed in star forming galaxies and related objects (Verhamme et al. 2006). Our code allows for prescribed arbitrary hydrogen density, ionisation, temperature structures, and dust distributions, and arbitrary velocity fields and UV photon sources.Here we present results from the first modelling of the Lyα line and of the UV spectrum with our code of a sample of z ~ 3 Lyman break galaxies observed by Steidel and collaborators (Pettini et al. 2002) and taken from the FORS Deep Field (Tapken et al. 2006). A simple model of an expanding neutral shell surrounding a starburst region can reproduce the whole variety of spectra ranging from double-peaked profiles to asymetric emission lines, P-Cygni profiles or broad absorption. The main determining parameters are the outflow velocity and the dust content. Other parameters such as the hydrogen column density, the intrinsic Lyα emission and hence SFR, and the intrinsic Lyα line widths can be determined consistently taking all radiation transfer effects into account.

We describe our results on multi-colour observations of extremely red galaxies found in two gravitational lensing clusters (Abell 1835 and AC114). Applying a colour criteria of R-K≥ 5.6 we have selected 12(10) EROs, of which 10(4) have no R-band detection. 5 of these objects have exceptional red colours (R-K>7.5). We compare their colours with other galaxy populations, like distant red galaxies and infrared detected extremely red galaxies, in order to differentiate between them.

Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions of the involved proteins at sites of DNA damage. Following damage recognition, dual incision 5′ to the lesion by ERCC1‐XPF and 3′ to the lesion by XPG leads to the removal of a lesion‐containing oligonucleotide of about 30 nucleotides. The resulting single‐stranded DNA (ssDNA) gap on the undamaged strand is filled in by DNA repair synthesis. Here, we have asked how dual incision and repair synthesis are coordinated in human cells to avoid the exposure of potentially harmful ssDNA intermediates. Using catalytically inactive mutants of ERCC1‐XPF and XPG, we show that the 5′ incision by ERCC1‐XPF precedes the 3′ incision by XPG and that the initiation of repair synthesis does not require the catalytic activity of XPG. We propose that a defined order of dual incision and repair synthesis exists in human cells in the form of a ‘cut‐patch‐cut‐patch’ mechanism. This mechanism may aid the smooth progression through the NER pathway and contribute to genome integrity.