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While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. Impaired blood flow leads to defective angiogenesis and osteogenesis, and downregulation of Notch signalling in endothelial cells. In aged mice, skeletal blood flow and endothelial Notch activity are also reduced leading to decreased angiogenesis and osteogenesis, which is reverted by genetic reactivation of Notch. Blood flow and angiogenesis in aged mice are also enhanced on administration of bisphosphonate, a class of drugs frequently used for the treatment of osteoporosis. We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system. Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.

Over the past decades, Western European municipalities increasingly reacted to the presence of immigrants with efforts to include these new residents in local policymaking. As part of this, many cities installed local immigrant councils, allowing newcomers to participate in the political sphere and to bring their needs and interests into the political process. Even though immigrant councils became strongly institutionalized in countries like Germany, their role has been described as ambiguous and their relationship with local authorities as unequal. Existing research has examined immigrant councils as a form of political participation and urban governance and investigated their institutional design and agency of involved actors. Yet, to date, we have little research that systematically links institutional structures and agency of immigrant councils with these bodies’ participation in local policymaking and their collaboration with municipal actors. Based on qualitative research on immigrant councils in two German cities, this article takes a fresh look at this form of immigrant political involvement in cities. It finetunes previous findings by showing that these bodies do not necessarily have to be tokenistic. Strengthening their political rights, countering forms of discrimination and side-lining of immigrant councils and bolstering the ownership of local officials and political leaders for these bodies are three strategies that can support these bodies’ political participation and their role in urban governance.

In both Germany and France, perceptions of immigration, diversity and their societal consequences have undergone important transformations in the past two decades. However, existing research has only partially captured such processes. The “grand narratives” of national approaches, while still influential, no longer explain contemporary realities. Further, analyses of national politics and discourses may not sufficiently reflect the realities across localities and society more broadly. While emerging in different national contexts, little is known about how diversity is actually perceived by political stakeholders at the urban level. Given the key role of immigration and diversity in current conflicts over Europe’s future, it is imperative to assess present-day conceptualisations of migration-related diversity among important societal actors. This article investigates perceptions and evaluations of socio-cultural heterogeneity by important societal actors in large cities. We contribute to existing literature by capturing an unusually broad set of actors from state and civil society. We also present data drawn from an unusually large number of cities. How influential is the perception of current society as heterogeneous, and what forms of heterogeneity are salient? And is socio-cultural and migration-related heterogeneity evaluated as threatening or rather as beneficial? Based on an original data set, this study explores the shared and contested ideas, the cognitive roadmaps of state and non-state actors involved in local politics. We argue that, in both German and French cities, socio-cultural heterogeneity is nowadays widely recognized as marking cities and often positively connoted. At the same time, perceptions of the main features of diversity and of the benefits and challenges attached to it vary. We find commonalities between French and German local actors, but also clear differences. In concluding, we suggest how and why national contexts importantly shape evaluations of diversity.

European cities are increasingly being recognised for the role they play in devising and implementing their own migration, integration and diversity policies. Yet very little is known about the local dimension of immigrant policymaking in crisis contexts. This introductory piece offers a rationale for analysing city-level immigrant policies in times of crisis and the salience of using crisis as a metaphor for the state of things, and outlines key scholarly works, debates, concepts and theories. It provides a range of historical and contemporary examples and considerations, and introduces an empirical city case study that is published as part of this mini-symposium. It argues that a crisis lens leads to a systematic understanding of local-level immigrant policymaking in recent and contemporary Western Europe. The mini-symposium’s focus and findings should be relevant to both on-going academic and policy debates.

PurposeTo assess the refractive improvements and the corneal endothelial safety of an individualised topography-guided regimen for corneal crosslinking in progressive keratoconus.MethodsAn open-label prospective randomised clinical trial was performed at the Department of Clinical Sciences, Ophthalmology, Umeå University Hospital, Umeå, Sweden. Thirty-seven patients (50 eyes) with progressive keratoconus planned for corneal crosslinking were included. The patients were randomised to topography-guided crosslinking (photorefractive intrastromal crosslinking (PiXL); n=25) or uniform 9 mm crosslinking (corneal collagen crosslinking (CXL); n=25). Visual acuity, refraction, keratometry (K1, K2 and Kmax) and corneal endothelial morphometry were assessed preoperatively and at 1, 3, 6 and 12 months postoperatively. The PiXL treatment involved an asymmetrical treatment zone centred on the area of maximum corneal steepness with treatment energies ranging from 7.2 to 15.0 J/cm2; the CXL treatment was a uniform 9 mm 5.4 J/cm2 pulsed crosslinking. The main outcome measures were changes in refractive errors and corneal endothelial cell density.ResultsThe spherical refractive errors decreased (p<0.05) and the visual acuity improved (p<0.01) at 3, 6 and 12 months after PiXL, but not after CXL. The between-groups differences, however, were not significant. K2 and Kmax decreased at 3, 6 and 12 months after PiXL (p<0.01), but not after CXL (p<0.01 when comparing the two treatments). No corneal endothelial cell loss was seen after either treatment.ConclusionsIndividualised topography-based crosslinking treatment centred on the ectatic cone has the potential to improve the corneal shape in keratoconus with decreased spherical refractive errors and improved visual acuity, without damage to the corneal endothelium.Trial registration numberNCT02514200, Results.

Sexting, defined as sending and receiving self-produced, sexually explicit images, is a widespread phenomenon among adolescents, which can have negative consequences, especially if an abusive dissemination occurs. In this study, a program on the prevention of the abusive distribution of sexually explicit images was developed and implemented for grades 6 and 7. The program was evaluated using a pre-, postand follow-up design. Students' program satisfaction, students' attitudes towards privacy on the internet and sexting, their knowledge about sexting and image rights, and their strategies handling sexting were measured. The results of the evaluation show that the adolescents (N = 132; 58.3 % female; Mage = 12.1 years, SD = 0.64) were satisfied with the program. There was a significant increase in knowledge. Furthermore, the results indicate an increase of strategies to cope with an unintentional distribution of a picture and strategies for a responsible use of sexting. Attitudes toward sexting were somewhat less critical after program participation. In addition to the successful implementation of the program in the school context, the results indicate that the program is effective.

An increasing sociocultural heterogeneity of populations and vocal demands for the recognition of diversity have become common features of, in particular, cities in Western Europe. Do cities reshape policies in response to such developments? And to what extent do they implement policies that accommodate difference? We use data from an original survey of urban policy actors in the twenty largest cities of France and Germany to identify city-level diversity policy instruments. In both countries, such instruments are widespread, contradicting assumptions of dominant assimilationist paradigms. And yet, the degree of adoption across cities varies. Drawing on institutionalist theory, we investigate what might explain differing adoption rates. The main finding is that key determinants at the urban level differ between the two countries. In France, the political constellation is crucial; higher numbers of diversity policies are associated with centre-left dominance. In contrast, in German cities, political consensus around diversity policies seems to prevail and higher adoption rates are associated with higher population diversity. Our findings provide a first wide-ranging account of the adoption of diversity policy instruments in European cities. They demonstrate that such policies exist at a relevant scale. They further help explain why the adoption of diversity policy instruments is uneven.

In my training as a social anthropologist, participant observation was taught as the core methodology of social anthropology. In seminars, I learned about fieldwork, where researchers assumed that their interlocutors have different intellectual capacities to abstract and reflect than the anthropologist. However, these assumptions about the less powerful and silent subject have become increasingly criticized over the past years, culminating in new ideas about the directionality and the character of fieldwork relations. My fieldwork as a ‘research trainee’ in municipal organizations in Amsterdam, Antwerp and Leeds in 2009– 10 was an experiment for conceiving my role and my relationship with

Sexting, defined as sending and receiving self-produced, sexually explicit images, is a widespread phenomenon among adolescents, which can have negative consequences, especially if an abusive dissemination occurs. In this study, a program on the prevention of the abusive distribution of sexually explicit images was developed and implemented for grades 6 and 7.The programwas evaluated using a pre-, post- and follow-up design. Students' program satisfaction, students' attitudes towards privacy on the internet and sexting, their knowledge about sexting and image rights, and their strategies handling sexting were measured. The results of the evaluation show that the adolescents (N = 132; 58.3 % female; M = 12.1 years, SD = 0.64) were satisfied with the program.There was a significant increase in knowledge. Furthermore, the results indicate an increase of strategies to cope with an unintentional distribution of a picture and strategies for a responsible use of sexting. Attitudes toward sexting were somewhat less critical after program participation. In addition to the successful implementation of the program in the school context, the results indicate that the program is effective.