Explore the vast range of titles available.

The great lakes of Europa The Galileo spacecraft revealed a number of 'chaos' regions on Jupiter's moon Europa, where the surface terrain appears to have been disrupted from below. In many places, the surface contains sharp-edged blocks or rafts of ice that have at some point been flipped or rotated. Some characteristics of these regions have been hard to explain, such as the fact that the archetypal Conamara Chaos stands above its surroundings and contains matrix domes. Schmidt et al . apply lessons learned from analogous processes within Earth's subglacial volcanoes and ice shelves to an analysis of archival data that suggests chaos terrain forms above liquid water 'lenses' that are perched only 3 kilometres deep within the ice shell. The data suggest that ice–water interactions and freeze-out give rise to the varied morphology of chaos terrains, implying that more water is involved than has been previously appreciated — for instance, the sunken topography of Thera Macula, a large chaos area, may indicate that Europa is actively resurfacing over a lens comparable in volume to North America's Great Lakes. Europa, the innermost icy satellite of Jupiter, has a tortured young surface 1 , 2 , 3 , 4 and sustains a liquid water ocean 1 , 2 , 3 , 4 , 5 , 6 below an ice shell of highly debated thickness 1 , 2 , 3 , 4 , 5 , 7 , 8 , 9 , 10 . Quasi-circular areas of ice disruption called chaos terrains are unique to Europa, and both their formation and the ice-shell thickness depend on Europa's thermal state 1 , 2 , 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 . No model so far has been able to explain why features such as Conamara Chaos stand above surrounding terrain and contain matrix domes 10 , 18 . Melt-through of a thin (few-kilometre) shell 3 , 7 , 8 is thermodynamically improbable and cannot raise the ice 10 , 18 . The buoyancy of material rising as either plumes of warm, pure ice called diapirs 1 , 9 , 10 , 11 , 12 , 13 , 14 , 15 or convective cells 16 , 17 in a thick (>10 kilometres) shell is insufficient to produce the observed chaos heights, and no single plume can create matrix domes 10 , 18 . Here we report an analysis of archival data from Europa, guided by processes observed within Earth's subglacial volcanoes and ice shelves. The data suggest that chaos terrains form above liquid water lenses perched within the ice shell as shallow as 3 kilometres. Our results suggest that ice–water interactions and freeze-out give rise to the diverse morphologies and topography of chaos terrains. The sunken topography of Thera Macula indicates that Europa is actively resurfacing over a lens comparable in volume to the Great Lakes in North America.

When intense light interacts with an atomic gas, recollision between an ionizing electron and its parent ion creates high-order harmonics of the fundamental laser frequency. This sub-cycle effect generates coherent soft X-rays and attosecond pulses, and provides a means to image molecular orbitals. Recently, high harmonics have been generated from bulk crystals, but what mechanism dominates the emission remains uncertain. To resolve this issue, we adapt measurement methods from gas-phase research to solid zinc oxide driven by mid-infrared laser fields of 0.25 volts per ångström. We find that when we alter the generation process with a second-harmonic beam, the modified harmonic spectrum bears the signature of a generalized recollision between an electron and its associated hole. In addition, we find that solid-state high harmonics are perturbed by fields so weak that they are present in conventional electronic circuits, thus opening a route to integrate electronics with attosecond and high-harmonic technology. Future experiments will permit the band structure of a solid to be tomographically reconstructed. © 2015 Macmillan Publishers Limited. All rights reserved.

The dwarf planet (1) Ceres, the largest object in the main asteroid belt, is found to have localized bright areas on its surface; particularly interesting is a bright pit on the floor of the crater Occator that exhibits what is likely to be water ice sublimation, producing crater-bound haze clouds with a diurnal rhythm. Possible ice sublimation on dwarf planet Ceres Images from NASA's Dawn orbiter spacecraft reveal localized bright areas on the surface of the dwarf planet Ceres, the largest object in the main asteroid belt. These unusual areas are consistent with the presence of hydrated magnesium sulfates mixed with dark background material, although other compositions are possible. Recent reports of water vapour, bound water and OH on Ceres raised the possibility there may be surface water there, and the new images reveal multiple bright spots on the floor of crater Occator that could be from surface ice. The largest of these, corresponding to the crater's central pit, produces haze clouds inside the crater with a diurnal rhythm, a clear indication of possible sublimation of water ice. The dwarf planet (1) Ceres, the largest object in the main asteroid belt 1 with a mean diameter of about 950 kilometres, is located at a mean distance from the Sun of about 2.8 astronomical units (one astronomical unit is the Earth–Sun distance). Thermal evolution models suggest that it is a differentiated body with potential geological activity 2 , 3 . Unlike on the icy satellites of Jupiter and Saturn, where tidal forces are responsible for spewing briny water into space, no tidal forces are acting on Ceres. In the absence of such forces, most objects in the main asteroid belt are expected to be geologically inert. The recent discovery 4 of water vapour absorption near Ceres and previous detection of bound water and OH near and on Ceres (refs 5 , 6 , 7 ) have raised interest in the possible presence of surface ice. Here we report the presence of localized bright areas on Ceres from an orbiting imager 8 . These unusual areas are consistent with hydrated magnesium sulfates mixed with dark background material, although other compositions are possible. Of particular interest is a bright pit on the floor of crater Occator that exhibits probable sublimation of water ice, producing haze clouds inside the crater that appear and disappear with a diurnal rhythm. Slow-moving condensed-ice or dust particles 9 , 10 may explain this haze. We conclude that Ceres must have accreted material from beyond the ‘snow line’ 11 , which is the distance from the Sun at which water molecules condense.

The dwarf planet (1) Ceres, the largest object in the main asteroid belt (1) with a mean diameter of about 950 kilometres, is located at a mean distance from the Sun of about 2.8 astronomical units (one astronomical unit is the Earth-Sun distance). Thermal evolution models suggest that it is a differentiated body with potential geological activity (2,3). Unlike on the icy satellites of Jupiter and Saturn, where tidal forces are responsible for spewing briny water into space, no tidal forces are acting on Ceres. In the absence of such forces, most objects in the main asteroid belt are expected to be geologically inert. The recent discovery (4) of water vapour absorption near Ceres and previous detection of bound water and OH near and on Ceres (refs 5-7) have raised interest in the possible presence of surface ice. Here we report the presence of localized bright areas on Ceres from an orbiting imager (8). These unusual areas are consistent with hydrated magnesium sulfates mixed with dark background material, although other compositions are possible. Of particular interest is a bright pit on the floor of crater Occator that exhibits probable sublimation of water ice, producing haze clouds inside the crater that appear and disappear with a diurnal rhythm. Slow-moving condensed-ice or dust particles (9,10) may explain this haze. We conclude that Ceres must have accreted material from beyond the 'snow line' (11), which is the distance from the Sun at which water molecules condense.

We obtained Hubble Space Telescope images of 2 Pallas in September 2007 that reveal distinct color and albedo variations across the surface of this large asteroid. Pallas's shape is an ellipsoid with radii of 291 (±9), 278 (±9), and 250 (±9) kilometers, implying a density of 2400 (±250) kilograms per cubic meter--a value consistent with a body that formed from water-rich material. Our observations are consistent with the presence of an impact feature, 240 (±25) kilometers in diameter, within Pallas's ultraviolet-dark terrain. Our observations imply that Pallas is an intact protoplanet that has undergone impact excavation and probable internal alteration.

Vascular contributions to cognitive impairment and dementia (VCID) include structural and functional blood vessel injuries linked to poor neurocognitive outcomes. Smoking might indirectly increase the likelihood of cognitive impairment by exacerbating vascular disease risks. Sex disparities in VCID have been reported, however, few studies have assessed the sex-specific relationships between smoking and memory performance and with contradictory results. We investigated the associations between sex, smoking, and cardiovascular disease with verbal learning and memory function. Using MindCrowd, an observational web-based cohort of ~ 70,000 people aged 18–85, we investigated whether sex modifies the relationship between smoking and cardiovascular disease with verbal memory performance. We found significant interactions in that smoking is associated with verbal learning performance more in women and cardiovascular disease more in men across a wide age range. These results suggest that smoking and cardiovascular disease may impact verbal learning and memory throughout adulthood differently for men and women.

The number of allogeneic hematopoietic SCTs performed globally each year continues to increase, paralleled by an increased demand for donors of therapeutic cells. Donor characteristics and collection procedures have undergone major changes during recent decades, and further changes are foreseen. Information on short- and long-term donor outcomes is of crucial importance to ensure maximal donor safety and availability. Current data, predominantly from unrelated donors, give reliable information on the frequent early events associated with donation—most of them of mild-to-moderate intensity. Information on the type and relative risk of serious adverse reactions is more limited. Moreover, only few data exist on long-term donor outcome. On the basis of this need, recommendations for a minimum data set for prospective donor follow-up were developed in a workshop with the participation of an international group of investigators actively involved in allogeneic stem cell donation under the auspices of and approved by the Worldwide Network for Blood and Marrow Transplantation. Establishment of a standardized global follow-up for both, related and unrelated, donors will enable monitoring of the short- and long-term safety profiles of hematopoietic cell donation and form a solid basis for future donor selection and counseling.

Since the beginning of hematopoietic stem cell harvesting from volunteer unrelated donors, ensuring donor safety has been a necessary goal of all parties involved in the process. As donation of BM or PBSCs is not in the interest of the donor's own physical health, donor registries and transplantation centers must take into account both medical and ethical aspects involved in the donation procedure. One of the principal goals leading to the formation of the World Marrow Donor Association (WMDA) was to establish internationally acceptable standards for all aspects of unrelated donor care.

The impact of immunosuppression despite virological suppression (immuno-virological discordance, ID) on the risk of developing fatal and non-fatal AIDS/non-AIDS events is unclear and remains to be elucidated. Patients in EuroSIDA starting at least 1 new antiretroviral drug with CD4<350 cells/µl and viral load (VL)>500 copies/mL were followed-up from the first day of VL< = 50 copies/ml until a new fatal/non-fatal non-AIDS/AIDS event. Considered non-AIDS events included non-AIDS malignancies, pancreatitis, severe liver disease with hepatic encephalopathy (>grade 3), cardio- and cerebrovascular events, and end-stage renal disease. Patients were classified over time according to whether current CD4 count was above (non-ID) or below (ID) baseline level. Relative rates (RR) of events were calculated for ID vs. non-ID using adjusted Poisson regression models. 2,913 patients contributed 11,491 person-years for the analysis of non-AIDS. 241 pre-specified non-AIDS events (including 84 deaths) and 89 AIDS events (including 10 deaths) occurred. The RR of developing pre-specified non-AIDS events for ID vs. non-ID was 1.96 (95% CI 1.37-2.81, p<0.001) in unadjusted analysis and 1.43 (0.94-2.17, p = 0.095) after controlling for current CD4 count. ID was not associated with the risk of AIDS events (aRR 0.76, 95% CI 0.41-1.38, p = 0.361). Compared to CD4 responders, patients with immuno-virological discordance may be at increased risk of developing non-AIDS events. Further studies are warranted to establish whether in patients with ID, strategies to directly modify CD4 count response may be needed besides the use of ART.