Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
22,820
result(s) for
"Schmidt, J."
Sort by:
Sex differences and the neurobiology of affective disorders
Observations of the disproportionate incidence of depression in women compared with men have long preceded the recent explosion of interest in sex differences. Nonetheless, the source and implications of this epidemiologic sex difference remain unclear, as does the practical significance of the multitude of sex differences that have been reported in brain structure and function. In this article, we attempt to provide a framework for thinking about how sex and reproductive hormones (particularly estradiol as an example) might contribute to affective illness. After briefly reviewing some observed sex differences in depression, we discuss how sex might alter brain function through hormonal effects (both organizational (programmed) and activational (acute)), sex chromosome effects, and the interaction of sex with the environment. We next review sex differences in the brain at the structural, cellular, and network levels. We then focus on how sex and reproductive hormones regulate systems implicated in the pathophysiology of depression, including neuroplasticity, genetic and neural networks, the stress axis, and immune function. Finally, we suggest several models that might explain a sex-dependent differential regulation of affect and susceptibility to affective illness. As a disclaimer, the studies cited in this review are not intended to be comprehensive but rather serve as examples of the multitude of levels at which sex and reproductive hormones regulate brain structure and function. As such and despite our current ignorance regarding both the ontogeny of affective illness and the impact of sex on that ontogeny, sex differences may provide a lens through which we may better view the mechanisms underlying affective regulation and dysfunction.
Journal Article
Global challenges in water governance : environments, economies, societies
This book presents a historically situated explanation of the rise of global water governance and the contemporary challenges that global water governance seeks to address. It is particularly concerned with connecting what are often technical issues in water management with the social and political structures that affect how technical and scientific advice affects decisions. Schmidt and Matthews are careful to avoid the pitfalls of setting up opposing binaries, such as 'nature versus culture' or 'private versus public', thereby allowing readers to understand how contests over water governance have been shaped over time and why they will continue to be so. Co-written by an academic and a practitioner, Global Challenges in Water Governance combines the dual concerns for both analytical clarity and practical applicability in a way that is particularly valuable both for educators, researchers, decision-makers, and newcomers to the complexities of water use decisions.
Book
Density Fluctuations across the Superfluid-Supersolid Phase Transition in a Dipolar Quantum Gas
Phase transitions share the universal feature of enhanced fluctuations near the transition point. Here, we show that density fluctuations reveal how a Bose-Einstein condensate of dipolar atoms spontaneously breaks its translation symmetry and enters the supersolid state of matter—a phase that combines superfluidity with crystalline order. We report on the first direct in situ measurement of density fluctuations across the superfluid-supersolid phase transition. This measurement allows us to introduce a general and straightforward way to extract the static structure factor, estimate the spectrum of elementary excitations, and image the dominant fluctuation patterns. We observe a strong response in the static structure factor and infer a distinct roton minimum in the dispersion relation. Furthermore, we show that the characteristic fluctuations correspond to elementary excitations such as the roton modes, which are theoretically predicted to be dominant at the quantum critical point, and that the supersolid state supports both superfluid as well as crystal phonons.
Journal Article
The new digital age : reshaping the future of people, nations and business
In collaboration, two leading global thinkers from in technology and foreign affairs from Google give readers their widely anticipated, transformational vision of the future: a world where everyone is connected, a world full of challenges and benefits that are ours to meet and to harness. With their combined knowledge and experiences, the authors are uniquely positioned to take on some of the toughest questions about our future: Who will be more powerful in the future, the citizen or the state? Will technology make terrorism easier or harder to carry out? What is the relationship between privacy and security, and how much will we have to give up to be part of the new digital age? In this they combine observation and insight to outline the promise and peril awaiting us in the coming decades. This is a forward-thinking account of where our world is headed and what this means for people, states and businesses. With the confidence and clarity of visionaries, the authors illustrate just how much we have to look forward to, and beware of, as the greatest information and technology revolution in human history continues to evolve. On individual, community and state levels, across every geographical and socioeconomic spectrum, they reveal the dramatic developments both good and bad, that will transform both our everyday lives and our understanding of self and society, as technology advances and our virtual identities become more and more fundamentally real. As their nuanced vision of the near future unfolds, an urban professional takes his driverless car to work, attends meetings via hologram and dispenses housekeeping robots by voice; a Congolese fisherwoman uses her smart phone to monitor market demand and coordinate sales (saving on costly refrigeration and preventing overfishing); the potential arises for \"virtual statehood\" and \"Internet asylum\" to liberate political dissidents and oppressed minorities, but also for tech-savvy autocracies (and perhaps democracies) to exploit their citizens' mobile devices for ever more ubiquitous surveillance. Along the way, we meet a cadre of international figures, including Julian Assange, who explain their own visions of our technology-saturated future. This book is an analysis of how our hyper-connected world will soon look.
Book
Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis
The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.
Journal Article
Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study
AbstractObjectiveTo investigate whether adults with atopic eczema are at an increased risk of cardiovascular disease and whether the risk varies by atopic eczema severity and condition activity over time.DesignPopulation based matched cohort study.SettingUK electronic health records from the Clinical Practice Research Datalink, Hospital Episode Statistics, and data from the Office for National Statistics, 1998–2015.ParticipantsAdults with a diagnosis of atopic eczema, matched (on age, sex, general practice, and calendar time) to up to five patients without atopic eczema.Main outcome measuresCardiovascular outcomes (myocardial infarction, unstable angina, heart failure, atrial fibrillation, stroke, and cardiovascular death).Results387 439 patients with atopic eczema were matched to 1 528 477 patients without atopic eczema. The median age was 43 at cohort entry and 66% were female. Median follow-up was 5.1 years. Evidence of a 10% to 20% increased hazard for the non-fatal primary outcomes for patients with atopic eczema was found by using Cox regression stratified by matched set. There was a strong dose-response relation with severity of atopic eczema. Patients with severe atopic eczema had a 20% increase in the risk of stroke (hazard ratio 1.22, 99% confidence interval 1.01 to 1.48), 40% to 50% increase in the risk of myocardial infarction, unstable angina, atrial fibrillation, and cardiovascular death, and 70% increase in the risk of heart failure (hazard ratio 1.69, 99% confidence interval 1.38 to 2.06). Patients with the most active atopic eczema (active >50% of follow-up) were also at a greater risk of cardiovascular outcomes. Additional adjustment for cardiovascular risk factors as potential mediators partially attenuated the point estimates, though associations persisted for severe atopic eczema.ConclusionsSevere and predominantly active atopic eczema are associated with an increased risk of cardiovascular outcomes. Targeting cardiovascular disease prevention strategies among these patients should be considered.
Journal Article
Being and time
The publication in 1927 of Martin Heidegger's magnum opus, Being and Time, signaled an intellectual event of the first order and had an impact in fields far beyond that of philosophy proper. Being and Time has long been recognized as a landmark work of the twentieth century for its original analyses of the character of philosophic inquiry and the relation of the possibility of such inquiry to the human situation. Still provocative and much disputed, Heidegger's text has been taken as the inspiration for a variety of innovative movements in fields ranging from psychoanalysis, literary theory, existentialism, ethics, hermeneutics, and theology. A work that disturbs the traditions of philosophizing that it inherits, Being and Time raises questions about the end of philosophy and the possibilities for thinking liberated from the presumptions of metaphysics. The Stambaugh translation captures the vitality of the language and thinking animating Heidegger's original text. It is also the most comprehensive edition insofar as it includes the marginal notes made by Heidegger in his own copy of Being and Time, and takes account of the many changes that he made in the final German edition of 1976. The revisions to the original translation correct some ambiguities and problems that have become apparent since the translation appeared fifteen years ago. Bracketed German words have also been liberally inserted both to clarify and highlight words and connections that are difficult to translate, and to link this translation more closely to the German text.
Book
Plasma concentrations and intakes of amino acids in male meat-eaters, fish-eaters, vegetarians and vegans: a cross-sectional analysis in the EPIC-Oxford cohort
Background/Objectives:
We aimed to investigate the differences in plasma concentrations and in intakes of amino acids between male meat-eaters, fish-eaters, vegetarians and vegans in the Oxford arm of the European Prospective Investigation into Cancer and Nutrition.
Subjects/Methods:
This cross-sectional analysis included 392 men, aged 30–49 years. Plasma amino acid concentrations were measured with a targeted metabolomic approach using mass spectrometry, and dietary intake was assessed using a food frequency questionnaire. Differences between diet groups in mean plasma concentrations and intakes of amino acids were examined using analysis of variance, controlling for potential confounding factors and multiple testing.
Results:
In plasma, concentrations of 6 out of 21 amino acids varied significantly by diet group, with differences of −13% to +16% between meat-eaters and vegans. Concentrations of methionine, tryptophan and tyrosine were highest in fish-eaters and vegetarians, followed by meat-eaters, and lowest in vegans. A broadly similar pattern was seen for lysine, whereas alanine concentration was highest in fish-eaters and lowest in meat-eaters. For glycine, vegans had the highest concentration and meat-eaters the lowest. Intakes of all 18 dietary amino acids differed by diet group; for the majority of these, intake was highest in meat-eaters followed by fish-eaters, then vegetarians and lowest in vegans (up to 47% lower than in meat-eaters).
Conclusions:
Men belonging to different habitual diet groups have significantly different plasma concentrations of lysine, methionine, tryptophan, alanine, glycine and tyrosine. However, the differences in plasma concentrations were less marked than and did not necessarily mirror those seen for amino acid intakes.
Journal Article