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104 result(s) for "Schmidt, Leonie"
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Acute placebo responsiveness predicts longitudinal expectation effects in antidepressant treatment
Positive treatment expectations are known to enhance antidepressant efficacy. Experimental placebo studies aim to provide mechanistic insights into this association, yet their findings have not been clearly linked to clinical expectation effects within individual patients. In a randomized crossover trial, 61 participants with major depressive disorder (31 women, 30 men) completed an emotion classification task and mood assessments after administration of a saline nasal spray labeled as either oxytocin (sham oxytocin treatment, deceptive placebo) or saline (control). Forty-five participants subsequently underwent antidepressant treatment and were monitored weekly for treatment expectations and depressive symptoms, with follow-ups extending to three months. Using linear mixed-effect models, we examined trajectories of clinical expectation effects and their prediction by experimental placebo-induced changes in emotional processing. Sham oxytocin treatment acutely induced positive expectations, improved mood, and shifted emotional processing toward positivity. Longitudinal modeling revealed that weekly reductions in depressive symptoms were predicted by higher treatment expectations reported the preceding week. These clinical expectation effects were most pronounced in individuals exhibiting strong acute placebo responses in emotional processing. Overall, our findings indicate that positive treatment expectations facilitate critical aspects of emotional processing in depression and that individual responsiveness generalizes across different treatments and time windows. Experimental placebo assessments offer an ecologically valid model for elucidating mechanisms and predictors of clinical expectation effects and highlight expectation sensitivity as a promising target for treatment optimization.
Islamic modernities in Southeast Asia
What does it mean to be a modern Muslim today? In contemporary discourse Islam and modernity are often presented as each other’s opposites in media and popular culture. Southeast Asia has a large Muslim population, especially in Indonesia, Malaysia, and Singapore, but Islamic culture in these states is conspicuously absent from the wider global discourse on Islam. With a focus on popular culture in Indonesia – a country that houses the world’s largest Muslim population and that is also undergoing modernisation –Islamic Modernities in Southeast Asia will demonstrate how Islamic modernities are being negotiated and constructed through popular and visual culture from a trans-regional perspective. Looking at a variety of Islamic-themed popular and visual culture including rock music, cinema, art, visual decorations in shopping malls, self-help books, and fashion blogs, the book explores how Islamic modernities are imagined, negotiated, contested, and shared in Southeast Asia.
The Twin Transformation Butterfly
Complex digitalization and sustainability challenges shape today’s management agendas. To date, the dedication of Information Systems research to both challenges has not been equal in terms of effort and reward. Building capabilities to leverage the synergetic potential of digital and sustainability transformation may enhance organizational performance and imply new value creation for the common good. To uncover such synergetic potential, this work conceptualizes the “twin transformation” construct as a value-adding reinforcing interplay between digital transformation and sustainability transformation efforts that improve an organization by leveraging digital technologies to enable sustainability and to guide digital progress by leveraging sustainability. The twin transformation conceptualization is complemented with a capability framework for twin transformation drawing from dynamic capability theory. This work contributes to descriptive knowledge of the interplay between digital transformation and sustainability transformation, setting a foundation for further theorizing on twin transformation and enabling organizations to twin transform.
Performing the Political
This chapter focuses on Anthony Wong and Tatming Pair, a duo Wong formed with Tats Lau. Tatming Pair released its debut in 1986 and has since built a reputation with its extravagant aesthetics, electronic sounds, and engaged lyrics. Both the 2012 and the 2017 concerts created a great buzz around the city of Hong Kong and were applauded for their political, musical, and aesthetic standards. Hong Kong's democracy struggle captured world's attention when crowds of people started occupying different areas of Hong Kong in September 2014, launching the city's pro-democracy movement to new heights. The chapter investigates how on each level of the production, makers and creative workers negotiate the tension between creating an appealing aesthetic spectacle on the one hand while trying to convey a political message on the other. Amidst contingency, driven by long-term personal connections, the concert came into being.