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196,050 result(s) for "Schmidt, S"
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GUNC: detection of chimerism and contamination in prokaryotic genomes
Genomes are critical units in microbiology, yet ascertaining quality in prokaryotic genome assemblies remains a formidable challenge. We present GUNC (the Genome UNClutterer), a tool that accurately detects and quantifies genome chimerism based on the lineage homogeneity of individual contigs using a genome’s full complement of genes. GUNC complements existing approaches by targeting previously underdetected types of contamination: we conservatively estimate that 5.7% of genomes in GenBank, 5.2% in RefSeq, and 15–30% of pre-filtered “high-quality” metagenome-assembled genomes in recent studies are undetected chimeras. GUNC provides a fast and robust tool to substantially improve prokaryotic genome quality.
Topical treatment options for the management of allergic conjunctivitis
Allergic conjunctivitis (AC) is a common ocular condition that affects individuals of all ages but is particularly prevalent among those with atopic tendencies. It is a hypersensitivity reaction to environmental allergens such as pollen or animal dander. Ocular symptoms include itching (a hallmark symptom of AC), tearing, redness, and chemosis. While it is not a vision-threatening condition, AC can cause significant discomfort and impair quality of life. Management begins with allergen avoidance and non-pharmacological measures such as cold compresses and lubricating eye drops. First-line pharmacological treatment of seasonal and perennial AC typically involves topical antihistamines with mast cell stabilising properties which provide rapid symptom relief and long-term mast cell stabilisation.
العلوم
يعد هذا الكتاب العلوم وهو مخصص للأطفال تستهدف الطفولة المبكرة وتعمل على استثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والابتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل من خلالها الكثير من العلم والمعرفة والمعلومات ويعد من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته وكيف يبني شخصيته بشكل مميز.
Focus on Broncol Cough Linctus
A cough is a protective reflex that helps remove irritants such as secretions (e.g. mucus, fluids, pus) and particles (e.g. infectious agents, foreign particles, harmful substances) from the airways.1-3 It is also one of the most common medical complaints for which individuals seek medical advice from both their doctors and community pharmacies.1,4
Comparing the levelized cost of electric vehicle charging options in Europe
With rapidly decreasing purchase prices of electric vehicles, charging costs are becoming ever more important for the diffusion of electric vehicles as required to decarbonize transport. However, the costs of charging electric vehicles in Europe are largely unknown. Here we develop a systematic classification of charging options, gather extensive market data on equipment cost, and employ a levelized cost approach to model charging costs in 30 European countries (European Union 27, Great Britain, Norway, Switzerland) and for 13 different charging options for private passenger transport. The findings demonstrate a large variance of charging costs across countries and charging options, suggesting different policy options to reduce charging costs. A specific analysis on the impacts and relevance of publicly accessible charging station utilization is performed. The results reveal charging costs at these stations to be competitive with fuel costs at typical utilization rates exhibited already today. Charging costs are important for the diffusion of electric vehicles as required to decarbonize transport. Here, the authors show large variance of electrical vehicle charging costs across 30 European countries and charging options, suggesting different policy options to reduce charging costs.