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PurposeThe determination of the measurement uncertainty is relevant for all measurement processes. In production engineering, the measurement uncertainty needs to be known to avoid erroneous decisions. However, its determination is associated to high effort due to the expertise and expenditure that is needed for modelling measurement processes. Once a measurement model is developed, it cannot necessarily be used for any other measurement process. In order to make an existing model useable for other measurement processes and thus to reduce the effort for the determination of the measurement uncertainty, a procedure for the migration of measurement models has to be developed.Design/methodology/approachThis paper presents an approach to migrate measurement models from an old process to a new “similar” process. In this approach, the authors first define “similarity” of two processes mathematically and then use it to give a first estimate of the measurement uncertainty of the similar measurement process and develop different learning strategies. A trained machine-learning model is then migrated to a similar measurement process without having to perform an equal size of experiments.Similarity assessment and model migrationFindingsThe authors’ findings show that the proposed similarity assessment and model migration strategy can be used for reducing the effort for measurement uncertainty determination. They show that their method can be applied to a real pair of similar measurement processes, i.e. two computed tomography scans. It can be shown that, when applying the proposed method, a valid estimation of uncertainty and valid model even when using less data, i.e. less effort, can be built.Originality/valueThe proposed strategy can be applied to any two measurement processes showing a particular “similarity” and thus reduces the effort in estimating measurement uncertainties and finding valid measurement models.

Manufacturing systems are undergoing systematic change facing the trade-off between the customer's needs and the economic and ecological pressure. Especially assembly systems must be more flexible due to many product generations or unpredictable material and demand fluctuations. As a solution line-less mobile assembly systems implement flexible job routes through movable multi-purpose resources and flexible transportation systems. Moreover, a completely reactive rearrangeable layout with mobile resources enables reconfigurations without interrupting production. A scheduling that can handle the complexity of dynamic events is necessary to plan job routes and control transportation in such an assembly system. Conventional approaches for this control task require exponentially rising computational capacities with increasing problem sizes. Therefore, the contribution of this work is an algorithm to dynamically solve the integrated problem of layout optimization and scheduling in line-less mobile assembly systems. The proposed multi agent deep reinforcement learning algorithm uses proximal policy optimization and consists of a decoder and encoder, allowing for various-sized system state descriptions. A simulation study shows that the proposed algorithm performs better in 78% of the scenarios compared to a random agent regarding the makespan optimization objective. This allows for adaptive optimization of line-less mobile assembly systems that can face global challenges.

The demand for individualized products drives modern manufacturing systems towards greater adaptability and flexibility. This increases the focus on data-driven digital twins enabling swift adaptations. Within the framework of cyber-physical systems, the digital twin is a digital model that is fully connected to the physical and digital assets. A digital model must follow a standardization for interoperable data exchange. Established ontologies and meta-models offer a basis in the definition of a schema, which is the first phase of creating a digital twin. The next phase is the standardized and structured modeling with static use-case specific data. The final phase is the deployment of digital twins into operation with a full connection of the digital model with the remaining cyber-physical system. In this deployment phase communication standards and protocols provide a standardized data exchange. A survey on the state-of-the-art of these three digital twin phases reveals the lack of a consistent workflow from ontology-driven definition to standardized modeling. Therefore, one goal of this paper is the design of an end-to-end digital twin pipeline to lower the threshold of creating and deploying digital twins. As the task of establishing a communication connection is highly repetitive, an automation concept by providing structured protocol data is the second goal. The planning and control of a line-less assembly system with manual stations and a mobile robot as resources and an industrial dog as the product serve as exemplary digital twin applications. Along this use-case the digital twin pipeline is transparently explained.

PurposeIn the determination of the measurement uncertainty, the GUM procedure requires the building of a measurement model that establishes a functional relationship between the measurand and all influencing quantities. Since the effort of modelling as well as quantifying the measurement uncertainties depend on the number of influencing quantities considered, the aim of this study is to determine relevant influencing quantities and to remove irrelevant ones from the dataset.Design/methodology/approachIn this work, it was investigated whether the effort of modelling for the determination of measurement uncertainty can be reduced by the use of feature selection (FS) methods. For this purpose, 9 different FS methods were tested on 16 artificial test datasets, whose properties (number of data points, number of features, complexity, features with low influence and redundant features) were varied via a design of experiments.FindingsBased on a success metric, the stability, universality and complexity of the method, two FS methods could be identified that reliably identify relevant and irrelevant influencing quantities for a measurement model.Originality/valueFor the first time, FS methods were applied to datasets with properties of classical measurement processes. The simulation-based results serve as a basis for further research in the field of FS for measurement models. The identified algorithms will be applied to real measurement processes in the future.

Conventional optical elements are bulky and limited to specific functionalities, contradicting the increasing demand of miniaturization and multi-functionalities. Optical metasurfaces enable tailoring light-matter interaction at will, especially important for the infrared spectral range which lacks commercially available beam-shaping elements. While the fabrication of those metasurfaces usually requires cumbersome techniques, direct laser writing promises a simple and convenient alternative. Here, we exploit the non-volatile laser-induced insulator-to-metal transition of the plasmonic phase-change material In 3 SbTe 2 (IST) for optical programming of large-area metasurfaces for infrared beam-shaping. We tailor the geometric phase of metasurfaces with rotated crystalline IST rod antennas to achieve beam steering, lensing, and beams carrying orbital angular momenta. Finally, we investigate multi-functional and cascaded metasurfaces exploiting enlarged holography, and design a single metasurface creating two different holograms along the optical axis. Our approach facilitates fabrication of large-area metasurfaces within hours, enabling rapid-prototyping of customized infrared meta-optics for sensing, imaging and quantum information. Direct programming of functional metasurfaces is demonstrated by locally crystallizing the phase-change material In 3 SbTe 2 via laser irradiation. In 3 SbTe 2 is established as a versatile nanophotonic platform for beam steering, lensing, and holography.

The advent of AlphaGo and its successors marked the beginning of a new paradigm in playing games using artificial intelligence. This was achieved by combining Monte Carlo tree search, a planning procedure, and deep learning. While the impact on the domain of games has been undeniable, it is less clear how useful similar approaches are in applications beyond games and how they need to be adapted from the original methodology. We perform a systematic literature review of peer-reviewed articles detailing the application of neural Monte Carlo tree search methods in domains other than games. Our goal is to systematically assess how such methods are structured in practice and if their success can be extended to other domains. We find applications in a variety of domains, many distinct ways of guiding the tree search using learned policy and value functions, and various training methods. Our review maps the current landscape of algorithms in the family of neural monte carlo tree search as they are applied to practical problems, which is a first step towards a more principled way of designing such algorithms for specific problems and their requirements.

In this paper, a new measurement principle for decoupling mechanical and thermal signals in an OFDR measurement with integrated optical fibres is investigated. Previous methods for decoupling require additional measuring equipment or knowledge about the substrate properties. This new method is based solely on simultaneous measurements of two fibres with different temperature sensitivities resulting from different core doping processes. By exposing both fibres to the same thermal and mechanical load, the signal could be differentiated through the signal variations caused by the thermo-optical effect. The two fibres used in the tests have a sufficient response difference in the cryogenic temperature range. Therefore, the method is suitable for various applications, such as high-temperature superconductors as well as cryogenic and space applications.

CAR-T cell therapy is a promising treatment for acute leukemia and lymphoma. CAR-T cell therapies take a pioneering role in autologous gene therapy with three EMA-approved products. However, the chance of clinical success remains relatively low as the applicability of CAR-T cell therapy suffers from long, labor-intensive manufacturing and a lack of comprehensive insight into the bioprocess. This leads to high manufacturing costs and limited clinical success, preventing the widespread use of CAR-T cell therapies. New manufacturing approaches are needed to lower costs to improve manufacturing capacity and shorten provision times. Semi-automated devices such as the Miltenyi Prodigy ® were developed to reduce hands-on production time. However, these devices are not equipped with the process analytical technology necessary to fully characterize and control the process. An automated AI-driven CAR-T cell manufacturing platform in smart manufacturing hospitals (SMH) is being developed to address these challenges. Automation will increase the cost-effectiveness and robustness of manufacturing. Using Artificial Intelligence (AI) to interpret the data collected on the platform will provide valuable process insights and drive decisions for process optimization. The smart integration of automated CAR-T cell manufacturing platforms into hospitals enables the independent manufacture of autologous CAR-T cell products. In this perspective, we will be discussing current challenges and opportunities of the patient-specific but highly automated, AI-enabled CAR-T cell manufacturing. A first automation concept will be shown, including a system architecture based on current Industry 4.0 approaches for AI integration.

PurposeTo ensure product quality within a manufacturing process, inspection processes are indispensable. One task of inspection planning is the selection of inspection characteristics. For optimization of costs and benefits, key characteristics can be defined by which the product quality can be checked with sufficient accuracy. The manual selection of key characteristics requires substantial planning effort and becomes uneconomic if many product variants prevail. This paper, therefore, aims to show a method for the efficient determination of key characteristics.Design/methodology/approachThe authors present a novel Algorithm for the Selection of Key Characteristics (ASKC) based on an auto-encoder and a risk analysis. Given historical measurement data and tolerances, the algorithm clusters characteristics with redundant information and selects key characteristics based on a risk assessment. The authors compare ASKC with the algorithm Principal Feature Analysis (PFA) using artificial and historical measurement data.FindingsThe authors find that ASKC delivers superior results than PFA. Findings show that the algorithms enable the cost-efficient selection of key characteristics while maintaining the informative value of the inspection concerning the quality.Originality/valueThis paper fills an identified gap for simplified inspection planning with the method for the efficient selection of key features via ASKC.