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Quantum mechanics and the theory of gravity are presently not compatible. A particular question is whether gravity causes decoherence. Several models for gravitational decoherence have been proposed, not all of which can be described quantum mechanically. Since quantum mechanics may need to be modified, one may question the use of quantum mechanics as a calculational tool to draw conclusions from the data of experiments concerning gravity. Here we propose a general method to estimate gravitational decoherence in an experiment that allows us to draw conclusions in any physical theory where the no-signalling principle holds, even if quantum mechanics needs to be modified. As an example, we propose a concrete experiment using optomechanics. Our work raises the interesting question whether other properties of nature could similarly be established from experimental observations alone—that is, without already having a rather well-formed theory of nature to make sense of experimental data. Whether gravity causes decoherence is a natural question on the way of making quantum physics compatible with the theory of gravity. Here the authors devise a general method to estimate gravitational decoherence in any no-signalling physical theory, which holds even if quantum mechanics would be modified.

Quantum mechanics and the theory of gravity are presently not compatible. A particular question is whether gravity causes decoherence - an unavoidable source of noise. Several models for gravitational decoherence have been proposed, not all of which can be described quantum mechanically. In parallel, several experiments have been proposed to test some of these models, where the data obtained by such experiments is analyzed assuming quantum mechanics. Since we may need to modify quantum mechanics to account for gravity, however, one may question the validity of using quantum mechanics as a calculational tool to draw conclusions from experiments concerning gravity. Here we propose an experiment to estimate gravitational decoherence whose conclusions hold even if quantum mechanics would need to be modified. We first establish a general information-theoretic notion of decoherence which reduces to the standard measure within quantum mechanics. Second, drawing on ideas from quantum information, we propose a very general experiment that allows us to obtain a quantitative estimate of decoherence of any physical process for any physical theory satisfying only very mild conditions.Finally, we propose a concrete experiment using optomechanics to estimate gravitational decoherence in any such theory, including quantum mechanics as a special case. Our work raises the interesting question whether other properties of nature could similarly be established from experimental observations alone - that is, without already having a rather well formed theory of nature like quantum mechanics to make sense of experimental data.

But man is an intellectual as well as a physical being; he partakes of the nature of angels, as well as of the lower animals, and it becomes us as philanthropists and as Christians to inquire, how this second department of our interests is affected by the Sabbath. So intimate is the connexion between soul and body, so various and constant the reciprecal influences of the one upon the other, as to have led Dr.

Severe emotional disturbance is a term that has been the focus of much research attention in the area of child and adolescent behavior disorders and has been very broadly defined in the literature as aggressive, disruptive, externalized, hyperactive, and disobedient behavior. Attorneys, researchers, and clinicians continue to debate the nature and characteristics of severe emotional disturbance. This study was a program evaluation of the mainstreaming portion of a special education program that provides educational and psychological services to children who are seriously emotionally disturbed in an attempt to identify variables from two data sets that predict successful mainstreaming of the students into regular education classrooms. Variables in the first data set included diagnosis, length of stay in the program, psychotropic medication, family participation, Global Assessment of Functioning scores, and inclusion school. Variables included in the second data set were measures of anger management, attitudes toward school, teacher attitudes toward inclusion, student attitude toward inclusion, teacher inclusion experience, and inclusion school. Of the variables in either data set, only attitudes toward school proved statistically significant. An explanation of the negative findings for both studies is presented along with various implications of this study for the program, limitations of this study, directions for future research and conclusions.

Objective Failure rate in randomized controlled trials (RCTs) is > 50%, includes safety-problems, underpowered statistics, lack of efficacy, lack of funding or insufficient patient recruitment and is even more pronounced in oncology trials. We present results of a structured concept-development phase (CDP) for a phase III RCT on personalized radiotherapy (RT) in primary prostate cancer (PCa) patients implementing prostate specific membrane antigen targeting positron emission tomography (PSMA-PET). Materials and methods The 1 yr process of the CDP contained five main working packages: (i) literature search and scoping review, (ii) involvement of individual patients, patients’ representatives and patients’ self-help groups addressing the patients’ willingness to participate in the preparation process and the conduct of RCTs as well as the patient informed consent (PIC), (iii) involvement of national and international experts and expert panels (iv) a phase II pilot study investigating the safety of implementation of PSMA-PET for focal dose escalation RT and (v) in-silico RT planning studies assessing feasibility of envisaged dose regimens and effects of urethral sparing in focal dose escalation. Results (i) Systematic literature searches confirmed the high clinical relevance for more evidence on advanced RT approaches, in particular stereotactic body RT, in high-risk PCa patients. (ii) Involvement of patients, patient representatives and randomly selected males relevantly changed the PIC and initiated a patient empowerment project for training of bladder preparation. (iii) Discussion with national and international experts led to adaptions of inclusion and exclusion criteria. (iv) Fifty patients were treated in the pilot trial and in- and exclusion criteria as well as enrollment calculations were adapted accordingly. Parallel conduction of the pilot trial revealed pitfalls on practicability and broadened the horizon for translational projects. (v) In-silico planning studies confirmed feasibility of envisaged dose prescription. Despite large prostate- and boost-volumes of up to 66% of the prostate, adherence to stringent anorectal dose constraints was feasible. Urethral sparing increased the therapeutic ratio. Conclusion The dynamic framework of interdisciplinary working programs in CDPs enhances robustness of RCT protocols and may be associated with decreased failure rates. Structured recommendations are warranted to further define the process of such CDPs in radiation oncology trials.

A comprehensive analysis and simulation of two memristor-based neuromorphic architectures for nuclear radiation detection is presented. Both scalable architectures retrofit a locally competitive algorithm to solve overcomplete sparse approximation problems by harnessing memristor crossbar execution of vector–matrix multiplications. The proposed systems demonstrate excellent accuracy and throughput while consuming minimal energy for radionuclide detection. To ensure that the simulation results of our proposed hardware are realistic, the memristor parameters are chosen from our own fabricated memristor devices. Based on these results, we conclude that memristor-based computing is the preeminent technology for a radiation detection platform.

Fabrication of ultrasharp probes is of interest for many applications, including scanning probe microscopy and electron-stimulated patterning of surfaces. These techniques require reproducible ultrasharp metallic tips, yet the efficient and reproducible fabrication of these consumable items has remained an elusive goal. Here we describe a novel biased-probe field-directed sputter sharpening technique applicable to conductive materials, which produces nanometer and sub-nanometer sharp W, Pt-Ir and W-HfB 2 tips able to perform atomic-scale lithography on Si. Compared with traditional probes fabricated by etching or conventional sputter erosion, field-directed sputter sharpened probes have smaller radii and produce lithographic patterns 18–26% sharper with atomic-scale lithographic fidelity. Scanning probe microscopy and related techniques rely on the availability of very sharp tips. Here, a sharpening technique based on field-directed sputtering is demonstrated, resulting in ultrasharp metallic tips for use in scanning tunnelling microscopy as well as atomic-scale lithographic experiments.

THIS simple device consists of a weight attachment, the upper ends of which are so bent as to fit easily in two perforations near the end of the blades of Sims' Speculum. In operations on the uterus, many gynaecologists now prefer to use Sims' Speculum with the patients in dorsal or lithotomy position.

The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacterial binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects.