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At subduction zones, crustal material enters the mantle. Some of this material, however, is returned to the overriding plate through volcanic and plutonic activity. Magmas erupted above subduction zones show a characteristic range of compositions that reflect mixing in the magma source region between three components: hydrous fluids derived from the subducted oceanic crust, components of the thin veneer of subducted sediments and peridotite mantle rocks. The mechanism for mixing and transport of these components has been enigmatic. A combination of results from the fields of petrology, numerical modelling, geophysics and geochemistry suggests a two-step process. First, intensely mixed metamorphic rock formations—mélanges—form along the interface between the subducted slab and the mantle. As the mélange contains the characteristic three-component geochemical pattern of subduction-zone magmas, we suggest that mélange formation provides the physical mixing process. Then, blobs of low-density mélange material—diapirs—rise buoyantly from the surface of the subducting slab and transport the well-mixed mélange material into the mantle beneath the volcanoes. Magma erupted at subduction-zone volcanoes contains mantle rocks and a mixture of fluids and sediments derived from the subducted slab. A synthesis of work over past years provides an integrated physico-chemical framework for subduction zones with mixing at the slab–mantle interface and transport towards the surface volcanoes by buoyant diapirs.

Kimberlites are volatile-rich, occasionally diamond-bearing magmas that have erupted explosively at Earth’s surface in the geologic past 1 – 3 . These enigmatic magmas, originating from depths exceeding 150 km in Earth’s mantle 1 , occur in stable cratons and in pulses broadly synchronous with supercontinent cyclicity 4 . Whether their mobilization is driven by mantle plumes 5 or by mechanical weakening of cratonic lithosphere 4 , 6 remains unclear. Here we show that most kimberlites spanning the past billion years erupted about 30 million years (Myr) after continental breakup, suggesting an association with rifting processes. Our dynamical and analytical models show that physically steep lithosphere–asthenosphere boundaries (LABs) formed during rifting generate convective instabilities in the asthenosphere that slowly migrate many hundreds to thousands of kilometres inboard of rift zones. These instabilities endure many tens of millions of years after continental breakup and destabilize the basal tens of kilometres of the cratonic lithosphere, or keel. Displaced keel is replaced by a hot, upwelling mixture of asthenosphere and recycled volatile-rich keel in the return flow, causing decompressional partial melting. Our calculations show that this process can generate small-volume, low-degree, volatile-rich melts, closely matching the characteristics expected of kimberlites 1 – 3 . Together, these results provide a quantitative and mechanistic link between kimberlite episodicity and supercontinent cycles through progressive disruption of cratonic keels. Most kimberlites erupting in the past billion years on Earth did so about 30 million years after continental breakup, with dynamical and analytical models suggesting a control from rifting-related mantle delamination.

Purpose of the Review Globally, emergency departments are recognizing their rapidly growing number of older adult patients and some have responded with care models and associated processes broadly described under the umbrella of geriatric emergency departments (Geriatric EDs). This review seeks to identify emerging themes in the Geriatric ED literature from the period 2018–2023 to provide a synthesis of concepts and research to assist emergency medicine healthcare professionals and policymakers in improving the delivery of emergency medical care to older patients. Recent Findings Emerging themes in Geriatric EDs include “calls to action” in the field regarding 1) health system level integration; 2) developing care processes; 3) implementing minimum Geriatric ED standards; and, 4) setting future research agendas. The research is international in scope with contributions from Canada, Australia, United Kingdom, Belgium, and the United States among others. A focus on Geriatric EDs’ financial sustainability as well as the overall efficacy of the care model is apparent. Recent seminal resources in Geriatric EDs include the Geriatric Emergency Department Collaborative, the Geriatric Emergency Care Applied Research Network, and the Geriatric Emergency Department Accreditation program. Attention to workforce education and specific care process/protocols for screening/assessment, cognitive dysfunction and falls is growing. Overall findings support the effectiveness and potential of Geriatric EDs in enhancing emergency care for older adults. Summary A review providing an overview of current themes and future directions of Geriatric EDs through a thematic analysis of the current literature. Key Geriatric ED themes include four “calls for action”, assessment of the model’s financial sustainability, an examination of the model’s efficacy and quality, and an identification of key resources foundational to Geriatric EDs. Targeted Geriatric ED workforce education programs and attention to care processes are contributing to improving outcomes for older adult in the ED.

Accuracy of a median nerve block is normally assessed by testing skin sensitivity on the medial and dorsal aspects of fetlock and pastern. The present study evaluated subjective and objective analysis of skin surface temperature obtained with two different infrared (IR) thermography cameras (a high-end [FLIR P640] and a smartphone IR thermography device [FLIR One®]) before and after anaesthesia of the median nerve. Thermographic images were obtained at 0, 30, 60 and 90 minutes after performing a median nerve block with 2% mepivacaine hydrochloride. The subjective analysis of thermographic images using the FLIR P640 camera found assessors had >50% agreement for the presence of a nerve block (p<0.01) based on assessment of skin temperature within the expected dermatome of the median nerve. The objective analysis found skin temperature increases in the treated leg using the FLIR One® in the dorsal fetlock, dorsal pastern and medial pastern at 60 minutes, and the lateral pastern at 90 minutes (p<0.05). The treated leg, imaged using the FLIR P640 camera, had increases in skin temperature at the medial aspect of the fetlock at 60 minutes and lateral pastern at 90 minutes (p<0.05). Images obtained with the P640 camera had higher resolution and finer thermal detail. The images obtained with the FLIR One® camera had a wider temperature range with overall higher temperature measurements than the images obtained using the P640 camera (p<0.001). Skin temperatures in horses should be interpreted with caution when using the FLIR One® camera. Furthermore, the FLIR One® device detected an increase in skin surface temperature in both treated and non-treated legs and should not be used for assessment of a median nerve block. Infrared thermography appears to be useful for determining the presence of a high regional nerve block such as the median nerve block by observing increased temperatures of the skin surface after perineural anaesthesia. Further studies with a larger sample size as well as investigating the use of thermography for assessment of other regional nerve blocks are warranted.

Orchiectomy is performed in some species using only sedation and local anesthesia to decrease the expense of performing the procedure using general anesthesia. The objective of this study was to determine if dogs can be castrated safely and painlessly by using only sedation and local anesthesia. After dogs were sedated with intramuscularly administered xylazine (1 mg/kg) and subanesthetic ketamine (1 mg/kg), testes and skin were anesthetized with 2% lidocaine (6 mg/kg, total dose) buffered with sodium bicarbonate. Systolic, diastolic, and mean blood pressures; heart and respiratory rates; and movement scores were determined before and during surgery when manipulations were most likely to cause pain. No dog reacted substantially to injection of the combination of sedatives, and no dog reacted noticeably to injection of lidocaine. During surgery, the average heart rate was reduced from baseline by 40-60 beats per minute, and the average respiratory rate was reduced by ~10 breaths per minute. An overall reduction of arterial blood pressures was observed. All but one dog moved purposely in response to a toe pinch at the end of surgery. We found that sedating dogs intramuscularly with xylazine and a sub-anesthetic dose of ketamine and administering lidocaine at the incision site and intratesticularly allowed dogs to be castrated humanely and avoided the expense of general anesthesia and the need for hospitalization.

We depend upon the olfactory abilities of dogs for critical tasks such as detecting bombs, landmines, other hazardous chemicals and illicit substances. Hence, a mechanistic understanding of the olfactory system in dogs is of great scientific interest. Previous studies explored this aspect at the cellular and behavior levels; however, the cognitive-level neural substrates linking them have never been explored. This is critical given the fact that behavior is driven by filtered sensory representations in higher order cognitive areas rather than the raw odor maps of the olfactory bulb. Since sedated dogs cannot sniff, we investigated this using functional magnetic resonance imaging of conscious dogs. We addressed the technical challenges of head motion using a two pronged strategy of behavioral training to keep dogs' head as still as possible and a single camera optical head motion tracking system to account for residual jerky movements. We built a custom computer-controlled odorant delivery system which was synchronized with image acquisition, allowing the investigation of brain regions activated by odors. The olfactory bulb and piriform lobes were commonly activated in both awake and anesthetized dogs, while the frontal cortex was activated mainly in conscious dogs. Comparison of responses to low and high odor intensity showed differences in either the strength or spatial extent of activation in the olfactory bulb, piriform lobes, cerebellum, and frontal cortex. Our results demonstrate the viability of the proposed method for functional imaging of the olfactory system in conscious dogs. This could potentially open up a new field of research in detector dog technology.

This study aimed to investigate the impact of a horse hoof wall on three solid surfaces: steel, concrete and asphalt. Impact experiments were conducted for different impact angles and different initial impact velocities. The effect of impact surfaces, impact angles and initial impact velocities on the coefficient of restitution and the effective coefficient of friction were tested using one-way ANOVA. Analytical and numerical modeling of the impact were developed. The impact interval was divided into two phases: compression and restitution. For compression, a contact force with a damping term was used. The restitution was characterized by an elastic contact force. The stiffness and damping coefficients of the contact force were estimated from the normal impacts. The simulated velocities after the oblique impacts were compared to the velocities in the in vitro investigation. The coefficient of restitution varied significantly on different surfaces. The effective coefficient of friction was lower on steel compared to concrete and asphalt. The model presented in this study can be applied to refine the impact simulation of the equine hoof during locomotion.

Disability carries negative social meaning, and little is known about when (or if), in the process of health decline, persons identify themselves as \"disabled.\" We examine the social and health criteria that older adults use to subjectively rate their own disability status. Using a panel study of older adults (ages 72+), we estimate ordered probit and growth curve models of perceived disability over time. Total prevalent morbidity, functional limitations, and cognitive impairment are predictors of perceived disability. Cessation of driving and receipt of home health care also influence older adults' perceptions of their own disability. A dense social network slowed the rate of labeling oneself disabled, while health anxiety accelerated the process over time, independent of health status. When considering perceived disability, the oldest old use multidimensional criteria capturing function, recent changes in health status and social networks, and anxiety about their health.

Hourglass sector zoning, and related polar overgrowths, are common features of metamorphic tourmaline, developing as a result of variations in element preference on the different growth surfaces. For sector-zoned crystals, three domains are present for each growth zone (c+, c- and a), with compositional differences most distinct for Ca and Ti, and among c+ and c- sectors. Intersector differences vary, commonly showing decreasing fractionation from core to rim attributed to increasing metamorphic grade. Here we show that intersector element partitioning is temperature dependent and derive empirical geothermometers based on c+ - c- and c+- a partitioning of Ca and Ti. These thermometers are applicable over a range of temperatures and bulk-rock compositions. Intersector partitioning is not affected by re-equilibration and records and preserves complete T-histories of individual tourmaline grains from prograde to peak and on to retrograde growth. Information on element mobility is preserved by tourmaline composition, because intersector partitioning is independent of element concentration. These factors make intersector partitioning an ideal tool to elucidate the thermal history of tourmaline grains and thus their host environment and tourmaline's refractory nature preserves these signatures even into the sedimentary record. [PUBLICATION ABSTRACT]