Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,271
result(s) for
"Scott, Greg"
Sort by:
Area 51 : the graphic history of America's most secret military installation
\"Covering the entire sixty-plus-year history of this remote desert outpost with personal vignettes and realistic illustrations, 'Area 51' is the perfect introduction to the significant history made-- and still being made-- at this secret military base\"--Page 4 or cover.
Book
Sustainable development and geospatial information: a strategic framework for integrating a global policy agenda into national geospatial capabilities
The 2030 Agenda for Sustainable Development provides a new global policy to guide the way countries collectively manage and transform the social, economic, and environmental dimensions of people and the planet over the next 15 years. Achieving sustainable development presents all countries and the global policy community with a set of significant development challenges that are almost entirely geographic in nature. Many of the issues impacting sustainable development can be analyzed, modeled, and mapped within a geographic context, which in turn can provide the integrative framework necessary for global collaboration, consensus and evidence-based decision-making. However, and despite significant advances in geospatial information technologies, there is a lack of awareness, understanding and uptake, particular at the policy and decision-making level, of the vital and integrative role of geospatial information and related enabling architectures such as National Spatial Data Infrastructures. This paper reasons that the role of geospatial information in contributing to sustainable development has not adequately been described by either the sustainable development policy practice or by the geospatial professional community. This lack of policy and guidance, with commensurate critical gaps and connection points with national geospatial frameworks, is a visible impediment to developing countries and those most affected by the challenges and need to achieve sustainable development. The global geospatial community now has a unique opportunity to integrate and connect geospatial information into the global development agenda in a more holistic and sustainable manner, specifically in contributing their data resources toward measuring and monitoring the 17 Sustainable Development Goals, and their 169 associated targets, through the global indicator framework that anchors the 2030 Agenda for Sustainable Development. This paper introduces and discusses a new strategic framework for linking a global policy to national geospatial capabilities.
Journal Article
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
Fertility-linked demethylase
The histone H3K9 demethylase JHDM2A was known to play a role in transcriptional activation mediated by the androgen receptor. Now targeted disruption of the
Jhdm2a
gene in mice shows that the enzyme is involved in spermatogenesis and regulation of transition nuclear protein and protamine genes. This work points to a role for this histone demethylase in the late stages of sperm production and maturation, and
Jhdm2a
becomes a possible candidate gene for infertility syndromes that have not yet been fully characterized.
Targeted disruption of the gene for the histone H3K9 demethylase JHDM2A in mouse uncovers a role for the enzyme in spermatogenesis and regulation of transition nuclear protein and protamine genes.
Recent studies indicate that, similar to other covalent modifications, histone lysine methylation is subject to enzyme-catalysed reversion
1
,
2
. So far, LSD1 (also known as AOF2) and the jumonji C (JmjC)-domain-containing proteins have been shown to possess histone demethylase activity. LSD1 catalyses removal of H3K4me2/H3K4me1 through a flavin-adenine-dinucleotide-dependent oxidation reaction
3
. In contrast, JmjC-domain-containing proteins remove methyl groups from histones through a hydroxylation reaction that requires α-ketoglutarate and Fe(
ii
) as cofactors
4
. Although an increasing number of histone demethylases have been identified and biochemically characterized
1
,
2
, their biological functions, particularly in the context of an animal model, are poorly characterized. Here we use a loss-of-function approach to demonstrate that the mouse H3K9me2/1-specific demethylase JHDM2A (JmjC-domain-containing histone demethylase 2A, also known as JMJD1A) is essential for spermatogenesis. We show that
Jhdm2a
-deficient mice exhibit post-meiotic chromatin condensation defects, and that JHDM2A directly binds to and controls the expression of transition nuclear protein 1 (
Tnp1
) and protamine 1 (
Prm1
) genes, the products of which are required for packaging and condensation of sperm chromatin. Thus, our work uncovers a role for JHDM2A in spermatogenesis and reveals transition nuclear protein and protamine genes as direct targets of JHDM2A.
Journal Article
Lumping disparate emergency dispatch priority levels together creates an assumption error regarding ‘overtriage’
[...]a patient in the known cardiac-risk age range (≥ 35 years) with chest pain, but no other symptoms, based on current standards of care and practice, will require a timely response from an Advanced Life Support (ALS) crew to do a comprehensive cardiac assessment—regardless of the ultimate findings, treatment, and/or transport decision made by the attending paramedic crew. [See PDF for image] Fig. 1 Medical priority dispatch system response matrix In many ways the emergency communications dispatch center can be thought of as the entrance to the hospital emergency room, where a triage nurse makes a front-line decision as to which patients get seen immediately by the on-duty physician, which ones get put into an exam room where a nurse starts an assessment by taking vital signs and interviewing the patient, or which patients will sit in the waiting room until space and personnel are available for them. While the MPDS priority levels and Determinant Codes certainly have a strong association with patient acuity in the aggregate—i.e., the higher the priority of the code, the more likely the patient is to have a serious condition determined by the responding EMS crews [2, 3, 4, 5, 6, 7–8]—they are designed, by necessity, to find any and all potentially serious patient conditions at the point of dispatch, so that a timely and sufficient EMS response and their needed level of evaluation can be assigned. Yap J, Helmer J, Gessaroli M, Hutton J, Khan L, Scheuermeyer F, Wall N, Bolster J, Van Diepen S, Puyat J, Asamoah-Boaheng M, Straight R, Christenson J, Grunau B. Performance of the medical priority dispatch system in correctly classifying out-of-hospital cardiac arrests as appropriate for resuscitation.
Journal Article
Learning games : the science and art of development
\"This book provides an overview of the design and development of learning games using examples from those created by the authors over the last decade. It provides lessons learned about processes, successful approaches, and pitfalls that befall developers of learning games and educational transmedia experiences. The book includes stories from the authors' lives that give context to why and how they built these products to help the reader understand whether or not building a learning game is right for them and what challenges they might face. It also gives a framework for thinking ethically about design and research when it comes to designing complex digital systems like educational games.\"-- Publisher's website
Book
It’s time to talk to emergency medical dispatchers: survey study on performance feedback and patient outcome follow-up to EMDs
Background
Performance feedback and patient outcome follow-up are essential in emergency medical services. Prior literature has assessed the importance of feedback/follow-up on paramedics and emergency medical technicians, however there is a paucity of literature specific to emergency medical dispatchers (EMD). Our objective was to measure the frequency, satisfaction with, and importance of feedback/follow-up received by EMDs.
Methods
Anonymous electronic survey study of United States (US)-based (approximately 60,000) members of the International Academies of Emergency Dispatch (IAED). Definitions of performance feedback and outcome follow-up were provided. Survey questions regarding frequency of feedback, satisfaction with feedback, and importance of feedback were scored on a 4-point Likert scale and were summarized with frequency counts and percentages.
Results
A total of 256 responses were received from 13,723 members who opened the email invitation, although not all are US-based. Respondents were predominantly female (
n
= 163, 63.7%), white (
n
= 224, 87.5%) and had been a dispatcher for ≥ 10 years (
n
= 158, 61.7%). Nearly half (
n
= 119, 46.5%) indicated receiving no performance feedback in the prior 30 days and 77.7% (
n
= 199) indicated no patient outcome follow-up in the same time period. EMDs were dissatisfied more with the quantity (
n
= 189, 73.8%) and quality (
n
= 174, 68.0%) of follow-up, compared to the quantity (
n
= 102, 39.8%) and quality (
n
= 102, 39.8%) of feedback they receive. Respondents indicated receiving feedback was important in terms of overall job satisfaction (
n
= 222, 86.7%), ongoing medical education (
n
= 222, 86.7%), future patient care (
n
= 215, 84.0%), and mental health and wellbeing (
n
= 200, 78.1%). Follow-up was important in terms of overall job satisfaction (
n
= 208, 81.3%), mental health and wellbeing (
n
= 201, 78.5%), ongoing medical education (
n
= 193, 75.4%), and future patient care (
n
= 187, 73.0%).
Conclusion
Survey respondents indicated a paucity of both performance feedback and outcome follow-up and that there is more dissatisfaction with lack of the latter rather than the former. These findings suggest system-wide opportunities to improve communication to EMDs on performance and patient outcomes.
Clinical trial number
Not applicable.
Journal Article
Video ethnography in practice : planning, shooting, and editing for social analysis
Video Ethnography in Practice is a brief guide for students in the social disciplines who are required to produce an ethnographic video, the most significant new methodological technique in 21st century social analysis. The authors, both accomplished videographers, cover the basic techniques of creating a video that documents human culture and behavior with true stories of the process of videography throughout. This text shows how new technologies like smart phones, widely available video editing software, and YouTube, have turned video ethnography into something that is within reach of students in a conventional course framework.
eBook