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Architecting cloud computing solutions : build cloud strategies that align technology and economics while effectively managing risk
\"'Big Data' refers to a new class of data, to which 'big' doesn't quite do it justice. Much like an ocean is more than simply a deeper swimming pool, big data is fundamentally different to traditional data and needs a whole new approach. Packed with examples and case studies, this clear, comprehensive book will show you how to accumulate and utilise 'big data' in order to develop your business strategy. Big Data Demystified is your practical guide to help you draw deeper insights from the vast information at your fingertips; you will be able to understand customer motivations, speed up production lines, and even offer personalised experiences to each and every customer. With 20 years of industry experience, David Stephenson shows how big data can give you the best competitive edge, and why it is integral to the future of your business. \"--Publisher's description.
Book
Microarray analysis identifies coding and non-coding RNA markers of liver injury in whole body irradiated mice
Radiation injury from medical, accidental, or intentional sources can induce acute and long-term hepatic dysregulation, fibrosis, and cancer. This long-term hepatic dysregulation decreases quality of life and may lead to death. Our goal in this study is to determine acute changes in biological pathways and discover potential RNA biomarkers predictive of radiation injury. We performed whole transcriptome microarray analysis of mouse liver tissue (C57BL/6 J) 48 h after whole-body irradiation with 1, 2, 4, 8, and 12 Gray to identify significant expression changes in mRNAs, lncRNAs, and miRNAs, We also validated changes in specific RNAs through qRT-PCR. We used Ingenuity Pathway Analysis (IPA) to identify pathways associated with gene expression changes. We observed significant dysregulation of multiple mRNAs across all doses. In contrast, miRNA dysregulation was observed upwards of 2 Gray. The most significantly upregulated mRNAs function as tumor suppressors:
Cdkn1a
,
Phlda3
, and
Eda2r
. The most significantly downregulated mRNAs were involved in hemoglobin synthesis, inflammation, and mitochondrial function including multiple members of
Hbb
and
Hba
. The most significantly upregulated miRNA included: miR-34a-5p, miR-3102-5p, and miR-3960, while miR-342-3p, miR-142a-3p, and miR-223-3p were most significantly downregulated. IPA predicted activation of cell cycle checkpoint control pathways and inhibition of pathways relevant to inflammation and erythropoietin. Clarifying expression of mRNA, miRNA and lncRNA at a short time point (48 h) offers insight into potential biomarkers, including radiation markers shared across organs and animal models. This information, once validated in human models, can aid in development of bio-dosimetry biomarkers, and furthers our understanding of acute pathway dysregulation.
Journal Article
Bad for you : exposing the war on fun!
Bad For You presents facts, figures and more to debunk myths about things throughout history, such as comic books, video games, and texting, that have been deemed to cause bad behavior and psychological damage in children.
Book
Genomic analysis of the meningococcal ST-4821 complex–Western clade, potential sexual transmission and predicted antibiotic susceptibility and vaccine coverage
The ST-4821 complex (cc4821) is a leading cause of serogroup C and serogroup B invasive meningococcal disease in China where diverse strains in two phylogenetic groups (groups 1 and 2) have acquired fluoroquinolone resistance. cc4821 was recently prevalent among carriage isolates in men who have sex with men in New York City (USA). Genome-level population studies have thus far been limited to Chinese isolates. The aim of the present study was to build upon these with an extended panel of international cc4821 isolates.
Genomes of isolates from Asia (1972 to 2017), Europe (2011 to 2018), North America (2007), and South America (2014) were sequenced or obtained from the PubMLST Neisseria database. Core genome comparisons were performed in PubMLST.
Four lineages were identified. Western isolates formed a distinct, mainly serogroup B sublineage with alleles associated with fluoroquinolone susceptibility (MIC <0.03 mg/L) and reduced penicillin susceptibility (MIC 0.094 to 1 mg/L). A third of these were from anogenital sites in men who have sex with men and had unique denitrification gene alleles. Generally 4CMenB vaccine strain coverage was reliant on strain-specific NHBA peptides.
The previously identified cc4821 group 2 was resolved into three separate lineages. Clustering of western isolates was surprising given the overall diversity of cc4821. Possible association of this cluster with the anogenital niche is worthy of monitoring given concerns surrounding antibiotic resistance and potential subcapsular vaccine escape.
Journal Article
Criminology and public policy : putting theory to work
\"In the field of criminal justice, public policy is designed to address the problems brought on by criminal behavior and the response to that behavior. However, too often, the theories carefully developed in the academy fail to make their way into programs and policy. The editors and contributors to this second edition of Criminology and Public Policy highlight the recent development of \"translational criminology\" to address the growing movement in criminology to use the results of criminological research and theory to better inform policy and practice. The essays in Criminology and Public Policy propose an in-depth look at both theory and practice and how they are integrated across a number of key criminal justice problems--from racial and environmental concerns to gun control and recidivism rates as well as police use of force and mass incarceration. The end result is an essential volume that blends both theory and practice in an effort to address the critical problems in explaining, preventing, responding to, and correcting criminal behavior. Contributors include: Robert K. Ax, Michelle N. Block, Anthony A. Braga, Rod K. Brunson, Jennifer Carlson, Ronald V. Clarke, Shea Cronin, Megan Denver, Kevin M. Drakulich, Grant Duwe, Amy Farrell, Cheryl Jonson, Charis E. Kubrin, Justin Kurland, Megan Kurlychek, Shannon Magnuson, Daniel P. Mears, Robert D. Morgan, Kathleen Powell, Danielle Rudes, Cassia Spohn, Cody Telep, Natalie Todak, Glenn Trager, Jillian J. Turanovic, Sara Wakefield, Patricia Warren, David Weisburd, Michael D. White, Rob White, Lauren Wilson and the editors\"-- Provided by publisher.
Book
High risk and low prevalence diseases: Serotonin syndrome
Serotonin syndrome is a rare, frequently misdiagnosed, serious condition with high morbidity.
This review highlights the pearls and pitfalls of serotonin syndrome, including diagnosis, initial resuscitation, and management in the emergency department (ED) based on current evidence.
Serotonin syndrome is a potentially deadly toxidrome marked by excess serotonin receptor activity or neurotransmission. Features of serotonin syndrome include 1) neuromuscular excitation such as tremor, hyperreflexia, and clonus; 2) autonomic dysfunction such as tachycardia, hypertension/hypotension, and hyperthermia; and 3) altered mental status such as agitation, delirium, and coma. Although serotonin syndrome may be more obvious in patients who have overdosed on serotonergic agents such as serotonin reuptake inhibitors (SSRIs), multiple other medications may also cause serotonin syndrome. Alternative diagnoses such as sepsis, neuroleptic malignant syndrome, and decompensated hyperthyroidism should be considered. The primary components of therapy include stopping the offending agent and supportive care, which focuses on agitation control, monitoring for and treating hyperthermia, and managing autonomic instability.
An understanding of serotonin syndrome can assist emergency clinicians in diagnosing and managing this disease.
Journal Article
Reversible cerebral vasoconstriction syndrome: A narrative review for emergency clinicians
Reversible Cerebral Vasoconstriction Syndrome (RCVS) is a rare cause of severe headache that can mimic other causes of sudden, severe headache and result in frequent emergency department (ED) visits.
This narrative review provides an evidence-based update concerning the presentation, evaluation, and management of RCVS for the emergency clinician.
RCVS can present as recurrent, severe headaches that may be maximal in onset, known as a thunderclap headache. Distinguishing from other causes of thunderclap headache such as aneurysmal subarachnoid hemorrhage, cerebral venous thrombosis, and posterior reversible encephalopathy syndrome is challenging. Risk factors for RCVS include use of vasoactive substances, exertion, coughing, showering, sexual activity, and cervical artery dissection. Diagnosis relies on clinical features and imaging. Cerebral catheter digital subtraction angiography (DSA) is considered the gold standard imaging modality; however, computed tomography angiography or magnetic resonance angiography are reliable non-invasive diagnostic modalities. Treatment focuses on avoiding or removing the offending agent, administration of calcium channel blockers such as nimodipine, and reversing anticoagulation if bleeding is present. Although most cases have a benign course and resolve within 3 months, focal subarachnoid hemorrhage, intracerebral hemorrhage, permanent neurologic disability, or death can occur in a minority of cases.
Diagnosis and appropriate management of RCVS can be aided by understanding key aspects of the history and examination. The emergency clinician can then obtain indicated imaging, confirming the diagnosis and allowing for appropriate management.
Journal Article
Venomized
The story that began in VENOMVERSE reaches its epic conclusion! The Poisons, a species that hungers for super-powered symbiotes and their hosts, have picked their next target: the Marvel Universe itself! Their first objective? Put every superhuman in a Klyntar symbiote -- and then consume them! And with Venom and the X-Men still missing after the events of \"Poison-X,\" Earth stands defenseless! By the time they make it back home, Venom and the X-Men find dozens of heroes and villains unwillingly bonded with symbiotes. And when the Poisons consume one of their strongest allies, the champions of Earth must rally -- and stand against one of their own! But what do the Poisons have planned for Cletus Kasady, A.K.A. Carnage? And can anything in the galaxy stand in the way of...Poison Thanos?!
BOOK
Cerebral venous thrombosis: Diagnosis and management in the emergency department setting
Cerebral venous thrombosis (CVT) is an uncommon neurologic emergency associated with significant morbidity and mortality that can be difficult to differentiate from other conditions. It is important for the emergency clinician to be familiar with this disease as it requires a high index of suspicion, and early diagnosis and management can lead to improved outcomes.
This narrative review provides an evidence-based update concerning the presentation, evaluation, and management of CVT for the emergency clinician.
CVT is due to thrombosis of the cerebral veins resulting in obstruction of venous outflow and increased intracranial pressure. Early recognition is important but difficult as the clinical presentation can mimic more common disease patterns. The most common patient population affected includes women under the age of 50. Risk factors for CVT include pregnancy, medications (oral contraceptives), inherited thrombophilia, prior venous thromboembolic event, malignancy, recent infection, and neurosurgery. CVT can present in a variety of ways, but the most common symptom is headache, followed by focal neurologic deficit, seizure, and altered mental status. Imaging studies such as computed tomography (CT) venography or magnetic resonance (MR) venography should be obtained in patients with concern for CVT, as non-contrast CT will be normal or have non-specific findings in most patients. Treatment includes anticoagulation, treating seizures and elevated ICP aggressively, and neurosurgical or interventional radiology consultation in select cases.
CVT can be a challenging diagnosis. Knowledge of the risk factors, patient presentation, evaluation, and management can assist emergency clinicians.
Journal Article