Explore the vast range of titles available.

Initial reports of the role of the cytoskeleton in cancer indicated that tumor cells with a more disorganized cytoskeleton were more tumorigenic. These reports were based on stains for the F-actin cytoskeleton, for example, using phalloidin or anti-F-actin antibody reagents, and gave a basic impression of F-actin-based cytoskeletal integrity. Later developments emphasized the significance of the cytoskeletal elements in cell migration, presumably associated with either basement membrane invasion or metastasis, or both, with several specific proteins implicated in the formation of cell invadopodia. With the advent of genomics approaches, it has become clear that cytoskeletal related proteins are indeed common targets of mutagenesis in cancer and commonly rank among the most mutated proteins in cancers, presumably due to large coding region sizes and the significant stochastic component to human mutagenesis. This cytoskeletal genomics result is consistent with the loss of cytoskeleton integrity as a hallmark of tumor development, but raises the question of whether such mutational sensitivity relates to the migration and invadopodia aspects of tumor progression. In the present study, the authors report that it is possible to identify a set of cytoskeletal related proteins protected from mutation, in comparison to the commonly mutated cytoskeleton related proteins in certain, but not all cancer, datasets.

This study aimed to compare the effect on bar execution velocity and number of repetitions between two velocity-based resistance training protocols only differing in the set configuration of the full-squat (SQ) and bench-press (BP) exercises. Moderately strength-trained men were assigned to a traditional (TS, n = 9)- or an alternating-set (AS, n = 10) configuration group to perform four testing sessions against different relative loads (55–60–65–70% 1RM). Relative load, magnitude of intra-set velocity loss (%VL), number of sets, inter-set recovery time, and exercise order were matched for both groups in each session. Mean propulsive velocity of the first repetition (MPVfirst), average number of repetitions per set (NRS), total number of repetitions (TNR), and total training time per session (TT) were measured. No significant differences between training conditions were observed for any relative load in MPVfirst, NRS, and TNR in both exercises. The TS group completed a significantly higher number of repetitions (p < 0.05) at faster velocities (MPV > 0.9–1.1 m·s−1) in the SQ. In conclusion, training sessions performing AS between SQ and BP exercises with moderate relative loads and %VL result in similar bar execution velocity and volume, but in a more time-efficient manner, than the traditional approach.

A new species Plantago pyrophila Villarroel & J. R. I. Wood is described from the Serranias de Santiago de Chiquitos in the cerrados of eastern Bolivia. It is clearly adapted to survival in the cerrado environment where grassland fires are a frequent event. The new species is remarkable for being geographically isolated from other species of the genus, being the only species of Plantago known from the cerrado biome.