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Background: Music therapy (MT) is a non-pharmacological treatment increasingly used to reduce stress and anxiety in hospitalized children affected by cancers. The aim of this study was to evaluate the impact of MT on quality of life in children with cancer and determine its effect on cardiorespiratory rates. Methods: We conducted a quasi-experimental study between 1 April and 31 August 2021 at Bechir Hamza children’s Hospital in Tunis, including children treated for cancer. The child or parent completed the PedsQL Module Cancer French version 3.0 questionnaires before and after four weekly music therapy sessions. The child’s respiratory and heart rates were measured before and after each session. Results: We included 20 children whose mean age was 7 ± 4.5 years. The median value of the total questionnaire score increased from 57 [46; 70] to 72 [67; 85] (p < 10−3) noting a significant reduction in pain (p = 0.02), nausea (p = 0.009), and anxiety related to medical procedures (p = 0.009) and worry about the future (p = 0.005). We highlighted a significant decrease in respiratory and heart rate after MT (p < 0.05). Conclusions: MT has positive impact on quality of life in children with cancer and reduces stress by lowering their cardiorespiratory rates.

The specific role of chromatin modifying factors in the timely execution of transcriptional changes in gene expression to regulate organ size remains largely unknown. Here, we report that in Drosophila melanogaster depletion of the histone demethylase dLsd1 results in the reduction of wing size. dLsd1 depletion affects cell proliferation and causes an increase in DNA damage and cell death. Mechanistically, we have identified Transposable Elements (TEs) as critical dLsd1 targets for organ size determination. We found that upon dLsd1 loss many TE families are upregulated, and new TE insertions appear. By blocking this new TE activity, we could rescue the wing size phenotype. Collectively, our results reveal that the histone demethylase dLsd1 and maintenance of TE homeostasis are required to ensure proper wing size. Genetic experiments coupled with genomic analysis reveal the role of the histone demethylase dLsd1 in regulating organ size via the repression of transposable elements’ transcription and mobilization in the model organism Drosophila melanogaster .

A 36-wk gestation neonate, delivered via cesarean section due to severe preeclampsia, developed seizures attributed to perinatal asphyxia and was admitted to the NICU. [...]the persistence of nephrocalcinosis underscores the need for close monitoring and further research into its optimal use in neonates. Subcutaneous fat necrosis of the newborn and associated hypercalcemia: a systematic review of the literature.

Donohue syndrome (DS) is a rare and lethal autosomal recessive disease caused by mutations in the insulin receptor ( ) gene, manifesting marked insulin resistance, severe growth retardation, hypertrichosis, and characteristic dysmorphic features. We describe a new case of Donohue syndrome born at 37 weeks’ gestation of unrelated parents and presented with intra-uterine growth retardation, nipple hypertrophy, macropenis, distended abdomen, hirsutism and dysmorphic features. The clinical course showed failure to thrive, and episodes of alternating hypoglycemia and hyperglycemia. Laboratory tests revealed direct hyperbilirubinemia. The diagnosis of Donohue syndrome was established based on the above clinical characteristics and determination of the mutation. He was found to have homozygous nonsense mutation c. 2270 C>T (Arg924X) at exon 14 of the gene. He later developed enterocolitis and died at 3 months old. Prenatal diagnosis was performed for the family via chorionic villous biopsy. We try to explain gastrointestinal dysfunction seen in our patient.

Farmers’ organizations have become a central element in agricultural policies and have established themselves as key partners in development programs in developing countries. This study aims to create a business model for Melyane Mutual Agricultural Services Company (SMSA) in northeastern Tunisia. This business model will define, on the one hand, the necessary resources (financial, technical, human) to realize its future projects and demonstrate their viability, and, on the other hand, the strategies to overcome existing constraints while leveraging local resources and creating sustainable activities. Semi-structured interviews and detailed surveys were thus conducted with the SMSA board of directors and its mem¬bers. The business model, developed and validated by SMSA members, provides a clear strategy for income-generating activities to be implemented and investments to be made in the short and medium term. The development of SMSAs should therefore be integrated into a territorial development approach that focuses on enhancing local resources, with members leveraging their artisanal skills. Furthermore, considering the challenges SMSAs face in terms of effective management and visibility, their activities should be reinforced with a mechanism for technical assistance and support.

(1) Background: The Italian Constitutional Court’s decision n. 99/2019 abolished the distinction between physical and psychological health care in the Italian prison system. However, this and other changes to the penitentiary system present challenges to prison staff, which may vary based on their roles and backgrounds; (2) Purpose: To create a process of dialogue and collaboration that include different points of view, needs, and proposals regarding mental health in prisons, this study collects and integrates the perspectives of 91 prison staff who work in various capacities in eight prisons in northeast Italy. (3) Methods: Each participant was involved in either a focus group or a semi-structured interview, and thematic analysis was used to process the resulting transcripts; (3) Results: Through this process, 10 themes were derived that highlight the difficulties of working with prisoners with psychiatric disorders or psychological distress, including lack of human and economic resources, lack of positive communication between prisoners and society and a sense of professional incompetency; (4) Conclusions: Based on these themes, the need for increased points of view, dialogue, and collaboration between prison professionals and between prison and society is discussed, and the current feasibility of treating psychiatric disorders in prison is considered.

Confinement is a global strategy imposed by several countries with the aim of fighting Covid-19 pandemic. The objective of our study is to assess during confinement, nursing students 'social and mental well-being, their perceived educational training and future nursing career choices. A survey was carried out among 300 Tunisian undergraduate nursing students. Results showed that 54% of participants confirmed experiencing multiple difficulties in term of training through online courses. 49% of participants reported that pedagogical strategies are poorly adapted. 28% of participants were psychologically affected during confinement while 45% of them kept solid social bond with family and 44% conserved relationship with friends. These results should be seriously taken into consideration with initiatives to address educational strategies during crisis situation and to help students overcome negative effects of confinements in the future.