Explore the vast range of titles available.

Background: Allogeneic stem cell transplantation (allo-SCT) and chimeric antigen receptor (CAR) T-cell therapy offer potential complementary benefits.Purpose: This study aimed to ascertain whether incorporating consolidative allo-SCT after CAR T-cell therapy can augment the therapeutic outcomes of child and young adult patients with relapsed/refractory hematologic malignancy.Methods: A comprehensive literature search of PubMed, ScienceDirect, Cochrane Library, EBSCOHost, ProQuest, and the grey literature repositories was performed for articles published between May 5, 2014, and May 5, 2024. We included studies reporting consolidative allo-SCT following CAR T-cell therapy for treating hematologic malignancies in subjects aged ≤25 years old. The outcomes of interest were complete remission, survival, relapse, and mortality rates. The estimates were pooled using random-effects meta-analysis. The risk of bias was evaluated using the Newcastle-Ottawa Scale, while the certainty of evidence was assessed using GRADE. This study follows the PRISMA 2020 criteria and is registered in the PROSPERO database (CRD42023433417).Results: Twelve cohort studies involving 380 patients, primarily those with B-cell acute lymphoblastic leukemia (B-ALL), were included. The CAR T-cell+SCT group showed a trend toward higher complete remission (odds ratio [OR], 2.74; 95% confidence interval [CI], 0.88–8.54; P= 0.08; I2=57%; evidence, very low); lower mortality (OR, 0.58; 95% CI, 0.27–1.27; P=0.17; I2=0%; evidence, low), and decreased relapse (OR, 0.18; 95% CI, 0.06–0.56; P=0.003; I2=41%; evidence, low) rates than those who did not proceed to SCT. In addition, both overall survival and leukemia-free survival rates showed a favorable trend toward the CAR T-cell+SCT group, respectively (hazard ratio, 0.44; 95% CI, 0.25–0.77; P=0.005; I2=0%; evidence, low; and hazard ratio, 0.29; 95% CI, 0.17–0.49; P<0.00001; I2=0%; evidence, low). Common posttransplant toxicities include mild to moderate acute and chronic graft-versus-host diseases.Conclusion: Although the current level of evidence remains low or very low, allo-SCT following CAR T-cell infusion potentially benefits patient survival. Further clinical studies are required to confirm these findings.

Rare earth elements are often correlated to A-type granite. Unggan Granite is A-type granite which is located in Sijunjung Regency, West Sumatra. This study discusses the rare earth elements composition on A-type Unggan Granite and compares the element abundance to the nearest A-type granite from Sibolga. Total REE of the studied location in the part of Solok Quadrangle is averagely 860 ppm. XRF and ICP-MS at Center for Geology Survey were applied to measure the composition of major oxides, trace elements, and rare earth elements in the selected granite. Megascopically, the samples are dark red and coarse grain granites with quartz and feldspar as major minerals. Major oxides content of the samples affirms the samples as granite based on geochemistry composition. Ga, Nb, and Y amounts in the granites reveal the A-type affinity. The average REE abundance of Unggan Granite is higher than the A-type section of Sibolga Granite. The selected rock are classified in shoshonitic series with lanthanum and neodymium as the major REE. Negative Ce and negative Eu anomalies in normalized spider plot are detected in the samples. The granite characters are worth to be explored more for national income from rare earth elements resource.

The association between movement screening and physical fitness testing in athletes is conflicting, and therefore, this study aimed to examine the relationship between Functional Movement Screen (FMS) performance and physical performance in elite female youth football players. Twenty-two players from the national U16 team of Bosnia and Herzegovina underwent FMS and physical performance tests, including speed, agility, and jump assessments. Jump and speed performance score correlated well with ASLR, while the overall FMS score was not associated with any of the performance variables. These findings suggest that while certain movement patterns may impact athletic performance, the relationship between movement screening and physical performance is delicate. Coaches and practitioners should consider individual variations and sport-specific demands when interpreting FMS results in order to optimize and maximize athlete performance and reduce injury risks.

Background and Objectives: Resistance exercises (REs) are a type of physical activity that individuals from many age groups have been doing recreationally, both as amateurs and professionally, in their daily lives in recent years. It is crucial to understand the effects of such sports on cardiac morphology in order to maximize the benefit of training and to tailor the training content accordingly. The aim of this study was to investigate the relationship between training experience (TE) and left ventricular (LV) systolic and diastolic parameters and left atrial (LA) mechanical function in healthy subjects who regularly performed RE for different durations. Materials and Methods: Forty-five healthy adults [age = 28.91 ± 10.30 years, height = 178.37 ± 5.49 cm, weight = 83.15 ± 13.91 kg, body mass index = 26.03 ± 3.42 kg/m2, TE = 7.28 ± 6.49 years] who performed RE between 1 year and 20 years were included in our study. The transthoracic echocardiograms (ECHOs) of the participants were evaluated by the cross-sectional research method, which is often used to understand the current situation in a given time period. Correlations between TE and LV systolic and diastolic parameters and LA mechanical function were analyzed. Results: As a result, interventricular septal thickness (IVS; r = 0.33, p = 0.028), the aortic diameter systole (ADs; r = 0.56, p < 0.001), and aortic diameter diastole (ADd; r = 0.58, p < 0.001) were positively correlated with TE, indicating associations with increased left ventricular (LV) hypertrophy and reduced ventricular compliance, while the aortic strain (AS; r = −0.44, p = 0.002), aortic distensibility (AD; r = −0.62, p < 0.001), and diastolic flow parameters including E (r = −0.41, p = 0.005), E/A (r = −0.38, p = 0.011), and E/Em (r = −0.31, p = 0.041) were negatively correlated with TE, reflecting impairments in diastolic function. Conclusions: This study showed that diastolic parameters were adversely affected in chronic RE. Therefore, we think that these individuals may have decreased relaxation and filling functions of the heart, which may also reduce adequate oxygen and nutrient delivery to the tissues. In this context, cohort studies are needed to analyze in detail the reasons for the decrease in diastolic parameters in these individuals.

This study aims to investigate the impact of coach encouragement feedback circuit training (CEFCT) on the level of fitness, grit, and technical performance of youth sepak takraw athletes. A randomised control trial (RCT) design during 8 weeks was adopted. There were 80 young male sepak takraw athletes allocated into two groups: the CEFCT group (n = 40, 17.4 ± 1.22 years) and the control group (CG, n = 40, 17.5 ± 1.24 years). Paired sample t-test showed significant differences in fitness, grit and technical performance in CEFCT (all, p < .05) and CG (all, p < .05) from pre-test until post-test. In the 2-way ANOVA repeated measures test, we observed a significant time effect on physical fitness (all p < .05), along with a group effect (p < .05); however, there was no effect on the CMJ parameter (p > .05). Moreover, there was an interaction time * group in some parameters (p < .05), but it was not found in 10-mST (p > .05). At the same time, we found a time effect on grit (all, p < .05), but no difference in the group effect (all, p > .05). Furthermore, there was a time * group interaction on grit-maintaining interest (MI) (p < 005), but it was not found in grit-continuing efforts (CE) (p > .05). Finally, we found that there was an effect of time (all, p < .05) simultaneously with group (all, p < .05), but there was no time * group interaction (all, p > .05). The coach must apply encouragement during the circuit to increase the level of physical fitness, grit and technical performance of youth sepak takraw athletes.

Previous investigations of plutons in Sumatra were focused on age dating with minimum geochemistry composition analysis. The purpose of this study is to define the geochemistry classification of the intrusions in central Sumatra on describing the emplacement mechanism associated with Southeast Asia tectonics. The rocks composed of quartz, K-feldspar, and plagioclase with amphibole, biotite, epidote, and zircon as accessory minerals. Six of seven studied plutons range from monzodiorite to granite with metaluminous-slight peraluminous, medium to very high-K calc-alkaline, magnesian, calcic to calc-alkalic affinities. The studied samples depict a wide range of total REE composition of 39-1,369ppm. Most of the rocks denote Sr, Ti, Y, Ce, and Eu anomalies on the primitive-mantle and chondrite normalized diagram. LREE are more enriched in comparison to HREE with (La/Sm)N= 1.71-18.75 and (Gd/Lu)N= 0.15-2.59. Most of the studied plutons are classified in the I-type according to the A/CNK value, negative SiO2 to P2O5 correlation with magnesian and arc-associated character. A-type nature of Sijunjung Granite is displayed on its high silica and REE content with ferroan, calc-alkalic, and within-plate affinities. The existence of A-type intrusion implies an extensional setting during long time subduction episodes, which triggered I-type magmatism since Late Permian to Neogene in Sumatra.

The study purpose was to determine the effectiveness of using games in developing students' manipulative motion skills for elementary school students aged 10-12 years. Materials and methods. The study used a quasi-experimental design, consisting of 48 upper-class students divided into a control group and an experimental group. This research was conducted in Koroulon and Jaten elementary schools (Indonesia). Manipulative motion skills tests are given as pre-test and post-test. To analyze the data, MANOVA were used at a significance level of 0.05. The results showed that the experimental group students had higher scores on both dependent variables than the control group. This suggests that manipulative play significantly improved the experimental group of manipulative motion skills compared to the students in the control group. The conclusions in this study, show that the use of games is very effectively used in developing manipulative motion skills of elementary school students aged 10-12 years. Keywords: Manipulative motion skills, games, elementary school students