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The most readily-observable and influential cue to one's credibility is their confidence. Although one's confidence correlates with knowledge, one should not always trust confident sources or disregard hesitant ones. Three experiments (N = 662; 3- to 12-year-olds) examined the developmental trajectory of children's understanding of 'calibration': whether a person's confidence or hesitancy correlates with their knowledge. Experiments 1 and 2 provide evidence that children use a person's history of calibration to guide their learning. Experiments 2 and 3 revealed a developmental progression in calibration understanding: Children preferred a well-calibrated over a miscalibrated confident person by around 4 years, whereas even 7- to 8-year-olds were insensitive to calibration in hesitant people. The widespread implications for social learning, impression formation, and social cognition are discussed.

Two world trends are powerfully reshaping human existence: the degradation, if not destruction, of large parts of the natural world, and unprecedented technological development. At the nexus of these two trends lies technological nature—technologies that in various ways mediate, augment, or simulate the natural world. Current examples of technological nature include videos and live webcams of nature, robot animals, and immersive virtual environments. Does it matter for the physical and psychological well-being of the human species that actual nature is being replaced with technological nature? As the basis for our provisional answer (it is \"yes\"), we draw on evolutionary and cross-cultural developmental accounts of the human relation with nature and some recent psychological research on the effects of technological nature. Finally, we discuss the issue—and area for future research—of \"environmental generational amnesia.\" The concern is that, by adapting gradually to the loss of actual nature and to the increase of technological nature, humans will lower the baseline across generations for what counts as a full measure of the human experience and of human flourishing.

Challenges arise in researching health effects associated with chemical mixtures. Several methods have recently been proposed for estimating the association between health outcomes and exposure to chemical mixtures, but a formal simulation study comparing broad-ranging methods is lacking. We select five recently developed methods and evaluate their performance in estimating the exposure-response function, identifying active mixture components, and identifying interactions in a simulation study. Bayesian kernel machine regression (BKMR) and nonparametric Bayes shrinkage (NPB) were top-performing methods in our simulation study. BKMR and NPB outperformed other contemporary methods and traditional linear models in estimating the exposure-response function and identifying active mixture components. BKMR and NPB produced similar results in a data analysis of the effects of multipollutant exposure on lung function in children with asthma.

To compare SARS-CoV-2 antibody seroprevalence among children with seropositive confirmed COVID-19 case counts (case ascertainment by molecular amplification) in Colorado, USA, we conducted a cross-sectional serosurvey during May-July 2021. For a convenience sample of 829 Colorado children, SARS-CoV-2 seroprevalence was 36.7%, compared with prevalence of 6.5% according to individually matched COVID-19 test results reported to public health. Compared with non-Hispanic White children, seroprevalence was higher among Hispanic, non-Hispanic Black, and non-Hispanic other race children, and case ascertainment was significantly lower among Hispanic and non-Hispanic Black children. This serosurvey accurately estimated SARS-CoV-2 prevalence among children compared with confirmed COVID-19 case counts and revealed substantial racial/ethnic disparities in infections and case ascertainment. Continued efforts to address racial and ethnic differences in disease burden and to overcome potential barriers to case ascertainment, including access to testing, may help mitigate these ongoing disparities.

This study explored how emerging adults processed the COVID-19 pandemic based on their identity, mental well-being, and political ideology. Participants ( N  = 231; M age  = 20.3; SD  = 1.36) completed an online survey with five ordered measures: Dimensions of Identity Development Scale, pandemic processing narratives, pandemic experience questionnaire, the Patient Health Questionnaire-8, and political ideology and demographic questionnaire. Analyses revealed that individuals with poorer mental well-being and/or more liberal political ideology self-reported more negative effects of the pandemic on their lives. Yet, aspects of emerging adults’ identity development were associated with positive interpretation of experiences during the first year of the COVID-19 pandemic: Greater ‘ exploration in breadth ’ and ‘ identification with commitment ’ positively predicted redemptive arcs (finding the positive) in narratives about the pandemic. Finally, political ideology was an important factor in emerging adults’ experience of the pandemic. Notably, conservative participants self-reported better mental well-being, fewer negative effects of the pandemic, and higher levels of identity commitment. Yet, conservative participants with high levels of ‘ commitment making ’ were less likely to find the positive when writing about negative events. Whereas, greater ‘ commitment making’ reduced the likelihood of redemptive arcs when writing about a negative event, but only for those with a conservative political ideology. Together these results suggest that aspects of identity development may be protective when emerging adults face challenges and individual factors (e.g., well-being and political ideology) can also exert effects on emerging adults’ ability to navigate global and political crises.

Human-animal interaction (HAI) research is promising and provocative. On the one hand it provides evidence of the value of animals in therapeutic contexts and, on the other hand, raises questions of why and how animals garner these benefits. At the same time, HAI research has serious limitations. Mueller [this issue] provides a clear-headed critique of the field and, importantly, offers insightful suggestions for moving the HAI field forward.

Human papillomavirus (HPV) vaccine is safe and highly effective, yet HPV vaccination uptake remains suboptimal, necessitating novel interventions. Our objective was to describe the impact of a novel method of community-based participatory research, Boot Camp Translation (BCT), on HPV vaccination uptake. In a quasi-experimental matched-case-control study, we applied BCT to HPV-focused intervention programs for 9–17-year-olds in 6 pediatric clinics in 3 counties in Colorado from 6/2020 to 2/2021. In a 6-month BCT process, providers, clinic staff, parents, and adolescent patients collaboratively designed messages and campaigns to implement in their clinics. Control clinics (n = 16) were identified from the same county as intervention clinics and matched on number of patients and percentage of patients eligible for the Vaccine for Children (VFC) program. Baseline and post-intervention (each defined for a period of 6 months) HPV vaccination rates were estimated for each intervention and control clinic. Rates were compared using adjusted odds ratios (aOR) for the time-by-treatment interaction effect through hierarchical logistic regression models. There were 15,764 youths in intervention clinics and 33,155 in controls. HPV vaccine initiation and completion increased in both groups with greater improvement in initiation in intervention clinics compared to controls (intervention: 45.9 % to 56.7 %, control: 44.6 to 52.8 %; p < 0.001). In multivariable analyses, after adjustment for age, sex, race/ethnicity, percent VFC-eligibility, baseline rates, and clinic size, the odds ratio for initiation of the HPV vaccine series, baseline versus post-intervention, was 1.80 in intervention clinics (95 % confidence interval [CI], 1.71, 1.90) and 1.54 in control clinics (95 % CI, 1.49, 1.60) (interaction, p < 0.0001). For completion of the series, the odds in intervention clinics were 1.72 (95 % CI, 1.63, 1.82) and 1.52 (95 % CI, 1.47, 1.58) in control clinics (interaction, p < 0.0001). Boot Camp Translation is a promising method for increasing uptake of HPV vaccination in clinic settings.

•Boot Camp Translation was studied for promoting rural adolescent vaccination.•Rural counties were randomized in a study conducted during the COVID pandemic.•11–12-year-old vaccination decreased slightly; 13–17-year old coverage increased.•Vaccination outcomes did not differ between intervention and control counties.•Effect of BCT on vaccination is difficult to know due to influence of the pandemic. Routine vaccination coverage for adolescents living in the rural US is lower than adolescents living in urban areas. We sought to measure the effect of Boot Camp Translation (BCT), a community-based participatory intervention, on rural adolescent vaccination coverage. A cluster randomized controlled trial was performed September 2018-November 2021 involving 16 rural Colorado counties. Intervention county community members engaged in BCT to develop interventions to improve adolescent vaccination locally. Adolescent vaccination coverage was measured using the Colorado Immunization Information System. For 11–12-year-olds, HPV initiation, HPV up-to-date, MenACWY, and Tdap vaccination coverage was lower post- versus pre-intervention in the control and intervention groups. For 11–12-year-olds in the intervention group, there was no significant difference post- versus pre-intervention in the odds of HPV vaccine initiation (adjusted ratio of odds ratios [aROR] = 0.93, 95 %: 0.85–1.02, p = 0.10) or up-to-date HPV vaccination (aROR: 1.10, 95 % CI: 0.98–1.23, p = 0.11) compared with the control group. Among 11–12-year-olds, the decrease in the proportion vaccinated with MenACWY and Tdap in the intervention group was significantly greater than the control group. Among 13–17-year-olds, there were significant increases in HPV initiation, HPV up-to-date, MenACWY, and Tdap vaccination coverage from pre- to post-intervention for both groups, with no significant differences between groups. 11–12-year-old vaccination coverage decreased slightly from pre- to post-intervention while 13–17-year-old vaccination coverage increased. We saw no effect from the BCT intervention. Our findings about the effectiveness of BCT for improving vaccine uptake may not be generalizable because the study coincided with the COVID-19 pandemic. Clinical Trial Registry: This study was registered with ClinicalTrials.gov, NCT03955757.

COVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4-July 17, 2021, were analyzed by vaccination status across 13 U.S. jurisdictions that routinely linked case surveillance and immunization registry data. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval [CI] = 7.8-15.8) to 4.6 (95% CI = 2.5-8.5) between two periods when prevalence of the Delta variant was lower (<50% of sequenced isolates; April 4-June 19) and higher (≥50%; June 20-July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3-15.6) to 10.4 (95% CI = 8.1-13.3) and from 16.6 (95% CI = 13.5-20.4) to 11.3 (95% CI = 9.1-13.9). Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19-associated hospitalization and death. Getting vaccinated protects against severe illness from COVID-19, including the Delta variant, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies.COVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4-July 17, 2021, were analyzed by vaccination status across 13 U.S. jurisdictions that routinely linked case surveillance and immunization registry data. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval [CI] = 7.8-15.8) to 4.6 (95% CI = 2.5-8.5) between two periods when prevalence of the Delta variant was lower (<50% of sequenced isolates; April 4-June 19) and higher (≥50%; June 20-July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3-15.6) to 10.4 (95% CI = 8.1-13.3) and from 16.6 (95% CI = 13.5-20.4) to 11.3 (95% CI = 9.1-13.9). Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19-associated hospitalization and death. Getting vaccinated protects against severe illness from COVID-19, including the Delta variant, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies.