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"Sewell, Dean"
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Investigating the effectiveness of the Mediterranean diet in pregnant women for the primary prevention of asthma and allergy in high-risk infants: protocol for a pilot randomised controlled trial
Background
Over recent decades there has been a substantial increase in asthma and allergic disease especially in children. Given the high prevalence, and the associated high disease burden and costs, there is a need to identify effective strategies for the primary prevention of asthma and allergy. A recent systematic review of the literature found strong supportive epidemiological evidence for a protective role of the Mediterranean diet, which now needs to be confirmed through formal experimental studies. This pilot trial in pregnant women aims to establish recruitment, retention and acceptability of a dietary intervention, and to assess the likely impact of the intervention on adherence to a Mediterranean diet during pregnancy.
Methods/Design
This study was a pilot, two-arm, randomised controlled trial in a sample population of pregnant women at high risk of having a child who will develop asthma or allergic disease.
Discussion
The work ultimately aims to contribute to improving health outcomes through seeking to reduce the incidence of asthma and allergic problems. This pilot trial will prove invaluable in informing the subsequent planned large-scale, parallel group, randomised controlled trial.
Trial registration
ClinicalTrials.gov:
NCT01634516
Journal Article
Evaluation of a cycling pre-load time trial protocol in recreationally active humans
The need for greater sensitivity in exercise performance measures is of particular importance in nutritional intervention studies and such measures have been investigated in trained cyclists, but not in those who have no experience of laboratory testing and/or the need to pace their effort. The aim of the present study was to evaluate a mixed design approach (constant load then time-trial) endurance type cycle ergometer protocol using recreationally active participants not well accustomed to cycling. Seven participants including one female (age 25 ± 5 years; body mass 74.4 ± 9.3 kg; peak VO
2
3.91 ± 0.96 l) completed four repeat cycle tests. The test consisted of a “pre-load” (60 min at 65% of peak VO
2
) followed by a 20 min time trial (performance measure). Reliability for the performance measure was assessed by calculating the individual participant coefficient of variation (CV) and a mean CV for the group. Excluding a familiarisation trial, mean CV for the group was 3.4% (95% confidence interval between 2.0 and 10.1%). It is concluded that the performance test described can be used in recreationally active young adults with lower variation after one familiarisation trial. The protocol might be used to evaluate an intervention if changes in performance are expected to be greater than 3.4%, or greater than around 7% if a signal to noise ratio of 2: 1 was to be considered appropriate.
Journal Article
Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function
Background—The use of creatine (Cr) as a nutritional supplement to aid athletic performance has gained widespread popularity among athletes. However, concerns have recently been expressed over potentially harmful effects of short and long term Cr supplementation on health. Methods—Forty eight young healthy subjects were randomly allocated to three experimental protocols aimed at elucidating any potential health risks associated with five days (20 g/day) to nine weeks (3 g/day) of Cr supplementation. Venous blood samples were collected before and after periods of Cr supplementation and were analysed for some haematological indices, and for indices of hepatic, muscular, and renal dysfunction. Findings—All measured indices were well within their respective normal range at all times. Serum creatinine concentration tended to be increased the day after Cr supplementation. However, values had returned to baseline six weeks after the cessation of supplementation. These increases were probably attributable to increased creatinine production rather than renal dysfunction. No indication of impairment to the haematological indices measured, hepatic function, or muscle damage was apparent after Cr supplementation. Interpretation—These data provide evidence that there are no obvious adverse effects of acute or more chronic Cr supplementation on the haematological indices measured, nor on hepatic, muscle, and renal function. Therefore there is no apparent health risk associated with Cr supplementation to healthy people when it is ingested in quantities that have been scientifically proven to increase muscle Cr stores.
Journal Article
Ships Of The Desert
It's the world's most remote yacht club, and an irresistible lure for intrepid sailors. Dean Sewell catches the breeze at Lake Killamperpunna in outback south Australia. It's 9am and the...
Newspaper Article
SCENE TO SAVOUR
Wet'n'wild . . . teenagers brave a powerful swell at the North Curl Curl ocean pool. The pool is part of a series of rock pools that stretch from Palm Beach to Cronulla. Carved out of natural rock formations, they were originally constructed in the late 1800s as a way to protect swimmers from rips and shark attacks.; Wet'n'wild . . . teenagers brave a powerful swell at the North Curl Curl ocean pool. The pool is part of a series of rock pools that stretch from Palm Beach to Cronulla. Carved out of natural rock formations, they were originally constructed in the late 1800s as a way to protect swimmers from rips and shark attacks.
Newspaper Article